Reviewed, UniProtKB/Swiss-Prot Q54NS9 (AIFA_DICDI)

Names and origin

Protein names

Recommended name:
    Apoptosis-inducing factor homolog A
    EC=1.-.-.-

Gene names

Name:	aifA
ORF Names:	DDB_G0285003

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	408 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Putative FAD-dependent oxidoreductase By similarity.
Cofactor	FAD By similarity.
Sequence similarities	Belongs to the FAD-dependent oxidoreductase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 408	408	Apoptosis-inducing factor homolog A		PRO_0000331383
Regions
	Nucleotide binding	34 – 38	5	FAD Potential
Sites
	Binding site	69	1	FAD Potential
	Binding site	314	1	FAD Potential

Sequences

	Sequence		Length	Mass (Da)
	Q54NS9-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: EFD0FEFE47740C66	FASTA	408	45,761
	10 20 30 40 50 60 MNYLYNISES LKKIFNYFSS ITRDCEKKRV LIIGCGFGGS QVAKLLDSNF EVTVVERKQT 70 80 90 100 110 120 FFNSIASIRA IVEPELAKKI YIPYDKLLKN GKFIYGTVIE ISPTLVKLED GKELTFDYLV 130 140 150 160 170 180 IATGSNSLAP FKAPLEKISG TEIFNYYKDI SEQIKQAKSI LIVGGGSVGC EVVGEIINKY 190 200 210 220 230 240 PIKNKELAKK ITIVHSGNKL VSSKTNNKFN NLINESMKKR NVSVILNDRI EIPDDIKQCF 250 260 270 280 290 300 INQTSPNFQV SLKTYKTKNG LSIESDFVIW TIGIKLNSES YKTNFSNEIN EIGQIKVNQS 310 320 330 340 350 360 CQVQGYDNIF AIGDITDFDE LKTTYNALSH GNIVAKVIKD LSNGKNKNQL AKHKLLPPII 370 380 390 400 SLSLGPKDGL TQINSNLNFG SFISRILKSN NLLINRFQTH FNNPEPLK

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000073 Genomic DNA. Translation: EAL64965.1.
RefSeq	XP_639988.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3391072.
KEGG	ddi:DDBDRAFT_0186313.
Organism-specific databases
dictyBase	DDB_G0285003. aifA.
Family and domain databases
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR001327. Pyr_OxRdtase_NAD_bd. [Graphical view]
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR.
ProtoNet	Search...

Entry information

Entry name

AIFA_DICDI

Accession

Primary (citable) accession number: Q54NS9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	May 24, 2005
Last modified:	November 25, 2008
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)