Reviewed, UniProtKB/Swiss-Prot Q54SF7 (AATC_DICDI)

Names and origin

Protein names

Recommended name:
    Aspartate aminotransferase, cytoplasmic
    EC=2.6.1.1
Alternative name(s):
    Transaminase A

Gene names

Name:	aatB
ORF Names:	DDB_0230093

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	438 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
Cofactor	Pyridoxal phosphate By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	CytoplasmBy similarity.
Miscellaneous	In eukaryotes there are cytoplasmic and mitochondrial isozymes By similarity.
Sequence similarities	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 438	438	Aspartate aminotransferase, cytoplasmic
Sites
	Binding site	284	1	Pyridoxal phosphate (covalent) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54SF7-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: BBEF41B10942F121	FASTA	438	48,632
	10 20 30 40 50 60 MSTLEKVSER IKNSLFVPID NNNMQDSINS NEVSGQVATL FANVPLGPVD PILGVSTAFK 70 80 90 100 110 120 ADTDPRKVDT SVGAYRDENG KPYVLKCVFE AEKRLLGAPK EYLPIDGIPE FNKLSAKLLY 130 140 150 160 170 180 GDAMVGKEKR MVTVQALSGT GALRIGIIFI RKYLPAGTVV YISRPSWTNH HNICKESGVQ 190 200 210 220 230 240 SAEYAYYDPK TKGLDFTGMI NDMRAAPNGS VFVLHLCAHN PTGVDPTHEQ WNIIADVMRE 250 260 270 280 290 300 KNHIPFMDCA YQGYASGDLD YDAYSARLFL NRGFEMFSAQ SYSKNFGLYG ERTGALTIVS 310 320 330 340 350 360 HREDVIPKML SQLKMDIRAM YSSPPTHGAR LVTTVLSDPE LTALWVKELK EMSGRIKDVR 370 380 390 400 410 420 QKVLDALIAR KVPGNWEHIV NQIGMFTYTG LTKPQVDILV NKYHIYLLGS GRVSLAGLNN 430 KNIDYFADAI LDAVTSTQ

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000047 Genomic DNA. Translation: EAL66106.1.
RefSeq	XP_640082.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3391167.
KEGG	ddi:DDB_0230093.
Organism-specific databases
dictyBase	DDB0230093. aatB.
Family and domain databases
InterPro	IPR004839. Aminotrans_I/II. IPR000796. Asp_trans. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11879. Asp_trans. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
PRINTS	PR00799. TRANSAMINASE.
PROSITE	PS00105. AA_TRANSFER_CLASS_1. False negative. [Graphical view]
ProDom	Q54SF7. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

AATC_DICDI

Accession

Primary (citable) accession number: Q54SF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	September 23, 2008
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)