Reviewed, UniProtKB/Swiss-Prot Q54TV1 (ABCG6_DICDI)

Names and origin

Protein names

Recommended name:
    ABC transporter G family member 6

Gene names

Name:	abcG6
ORF Names:	DDB_0215376

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	1534 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane proteinBy similarity.
Sequence similarities	Belongs to the ABC transporter family. PDR subfamily. Contains 2 ABC transmembrane type-2 domains. Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Repeat Transmembrane
Ligand	ATP-binding Nucleotide-binding
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 1534	1534	ABC transporter G family member 6
Regions
	Transmembrane	486 – 506	21	Potential
	Transmembrane	521 – 541	21	Potential
	Transmembrane	566 – 586	21	Potential
	Transmembrane	592 – 612	21	Potential
	Transmembrane	625 – 645	21	Potential
	Transmembrane	652 – 672	21	Potential
	Transmembrane	734 – 754	21	Potential
	Transmembrane	1261 – 1281	21	Potential
	Transmembrane	1296 – 1316	21	Potential
	Transmembrane	1345 – 1365	21	Potential
	Transmembrane	1377 – 1397	21	Potential
	Transmembrane	1404 – 1424	21	Potential
	Transmembrane	1506 – 1526	21	Potential
	Domain	138 – 385	248	ABC transporter 1
	Domain	467 – 677	211	ABC transmembrane type-2 1
	Domain	924 – 1166	243	ABC transporter 2
	Domain	1242 – 1454	213	ABC transmembrane type-2 2
	Nucleotide binding	177 – 184	8	ATP 1 Potential
	Nucleotide binding	960 – 967	8	ATP 2 Potential
	Compositional bias	10 – 64	55	Asn-rich
	Compositional bias	762 – 821	60	Lys-rich
	Compositional bias	842 – 901	60	Asn-rich
Experimental info
	Sequence conflict	18	1	I → L in AAL91491. Ref.2
	Sequence conflict	51 – 52	2	NN → II in AAL91491. Ref.2
	Sequence conflict	824	1	T → P in AAL91491. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q54TV1-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: AB3DE3CA581517DE	FASTA	1,534	173,651
	10 20 30 40 50 60 MAKQDPKDKN SDSPNLSIPI NNNNNENLDN DQELLNNNNN NNNNNNNNNN NNNNNNNNNN 70 80 90 100 110 120 NNNNLISSSR KHKDEESNYD SDDEKSVYQI AKEHEGEDDG DDEYFPIPLD ELMPNHENDE 130 140 150 160 170 180 LTKKIKQTRP EDKTGLYVYC RNATYTVKHR ENKKVKIKLI DDISFYLKPK EMTLILGTPG 190 200 210 220 230 240 CGKSTIFQML AGQLKDKHFK GELLFNGHPI NHKNHHRDIS YVTQDDIHVP TLTVKETFRF 250 260 270 280 290 300 ALDCLGRKEL TNEEKKETVD NCMNLLGLKE SENTVVGDNF VRGISGGQKK RVTIGVGVIK 310 320 330 340 350 360 GSNLLLMDEP TSGLDSSTSF EILSDVKKFV TYGYSPALIT LLQPSVQLTS LFDNLMILNK 370 380 390 400 410 420 GRICYFGPMN KALGYFKKLG FACPSHNNPA EFFQEVVDAP ERYSFIHPPK CKTSKDFVRA 430 440 450 460 470 480 YRESEFYKDL MEKMDANKDG IVDDNKPKVL VDSTAKELGM YPHGIGYQTK ICMKRGFTMI 490 500 510 520 530 540 RRNYYNFLTR VAKGIFFGLL LGTLYWRIGH NQSGGMERFG LLFFIMVTII FSSFAAVNSF 550 560 570 580 590 600 FGERKVFYSQ KALYYYKTGA YFISSIICDI PAGILEVAFF GPIVYWLANL RPVFIRFVYF 610 620 630 640 650 660 MLLLIMTDNL SLSFAKMCAA ISPTIEIANV IASVILSIWL LFSGFTAPKN DIGGWWIWLY 670 680 690 700 710 720 YISPYTWIFQ GLSINEFTYQ EYGCKTSELI PPRTPQNLLP YPEGFGGNQV CQFTSGEQIM 730 740 750 760 770 780 DAFGITNPNY FKWVVFGILS AYIVFFYVVC FFALKYFNFE DKKSKLAVKK LKKKKKVKTT 790 800 810 820 830 840 KQDEESAAIS SEALERIDDD NDDDADYETE IKKKKSHKKQ KEDTVIDVKS PSSLTTGSPY 850 860 870 880 890 900 YNINNNNNNL SGSGNNIKKR KVKTPSNLSP SVNSPITINS PMPTSPSNNN NNNNSNEKSK 910 920 930 940 950 960 NGKDIGSETG SYLQFKKLCY AVDVKVDDPD NPKKKKSQRL QLLTDIDGYV KPGQMLALMG 970 980 990 1000 1010 1020 PSGAGKSTLL DVLAQRKTGG HITGEILING KPPSEFTNRI RAYVEQMDVL PPTQTVREAI 1030 1040 1050 1060 1070 1080 AFSARCRLPP EVTKEERESY VDKIVEVLSL SSIKDLKIGV LGDGLSVSQR KRVNIGVELA 1090 1100 1110 1120 1130 1140 SNPEILFLDE PTSGLDSGDA FKVIDVVNKI AKVMNRTVIC TVHQPSAAIF EFFDQLLLLK 1150 1160 1170 1180 1190 1200 QGGETIYFGP LGNQSSVILD YCDKLGMHIK PHINPADFVM TLADQGKMVE GPNGEQVPLD 1210 1220 1230 1240 1250 1260 AKKAYFESDI CKKEYEIMEG QLIPDDFVIK TYDSRFASSW MTQFRALCMR SWLSRLRRPA 1270 1280 1290 1300 1310 1320 IFVSNCIRSI LLAVLLGTLF VRMDYEQKDA RSRVSLLFFS FLFAGMVAIG NIPTTVLERG 1330 1340 1350 1360 1370 1380 VFYREVTAGF YHSTAYMTSY VLTSYPFTLS TGILYIIPTF WIAGLDSGRH SSKFWYCLFI 1390 1400 1410 1420 1430 1440 FIITYVMYDA FGLCLAVCLP NEVMASTICG IGLSLSTLFG GFVIARPNYP SAYYWCHYLD 1450 1460 1470 1480 1490 1500 WLRYPLEASC TNEFTGLTFV CTNNKGAVPI PIIENGVQIA IKYYCPITNG DDFMLTYGFH 1510 1520 1530 KFMRYIDIAA IFGYIFIFVG LSFWGFKKIR WFNR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"Evolutionary analyses of ABC transporters of Dictyostelium discoideum." Anjard C., Loomis W.F. Eukaryot. Cell 1:643-652(2002) [PubMed: 12456012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-1534. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000041 Genomic DNA. Translation: EAL66676.1. AF482385 Genomic DNA. Translation: AAL91491.1.
RefSeq	XP_640710.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3391766.
KEGG	ddi:DDB_0215376.
Organism-specific databases
dictyBase	DDB0215376. abcG6.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase_core. IPR013525. ABC_2_trans. IPR003439. ABC_transporter-like. IPR010929. PDR_CDR_ABC. [Graphical view]
Pfam	PF01061. ABC2_membrane. 2 hits. PF00005. ABC_tran. 2 hits. PF06422. PDR_CDR. 1 hit. [Graphical view]
ProDom	PD000006. ABC_transporter. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS51012. ABC_TM2. False negative. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ABCG6_DICDI

Accession

Primary (citable) accession number: Q54TV1
Secondary accession number(s): Q8T687

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	May 24, 2005
Last modified:	September 2, 2008
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)