Reviewed, UniProtKB/Swiss-Prot Q54TV2 (ABCG5_DICDI)

Names and origin

Protein names

Recommended name:
    ABC transporter G family protein 5

Gene names

Name:	abcG5
ORF Names:	DDB_0215344

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	1509 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane proteinBy similarity.
Sequence similarities	Belongs to the ABC transporter family. PDR subfamily. Contains 2 ABC transmembrane type-2 domains. Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Repeat Transmembrane
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 1509	1509	ABC transporter G family protein 5
Regions
	Transmembrane	477 – 497	21	Potential
	Transmembrane	512 – 532	21	Potential
	Transmembrane	557 – 577	21	Potential
	Transmembrane	583 – 603	21	Potential
	Transmembrane	616 – 636	21	Potential
	Transmembrane	643 – 663	21	Potential
	Transmembrane	725 – 745	21	Potential
	Transmembrane	1236 – 1256	21	Potential
	Transmembrane	1271 – 1291	21	Potential
	Transmembrane	1320 – 1340	21	Potential
	Transmembrane	1352 – 1372	21	Potential
	Transmembrane	1379 – 1399	21	Potential
	Transmembrane	1481 – 1501	21	Potential
	Domain	129 – 376	248	ABC transporter 1
	Domain	458 – 668	211	ABC transmembrane type-2 1
	Domain	888 – 1141	254	ABC transporter 2
	Domain	1217 – 1429	213	ABC transmembrane type-2 2
	Nucleotide binding	168 – 175	8	ATP 1 Potential
	Nucleotide binding	935 – 942	8	ATP 2 Potential
	Compositional bias	21 – 66	46	Asn-rich
	Compositional bias	760 – 767	8	Poly-Lys
	Compositional bias	818 – 824	7	Poly-Asn
Experimental info
	Sequence conflict	137	1	T → P in AAL91490. Ref.1
	Sequence conflict	510	1	F → L in AAL91490. Ref.1
	Sequence conflict	1160	1	E → Q in AAL91490. Ref.1
	Sequence conflict	1172 – 1173	2	EH → VP in AAL91490. Ref.1
	Sequence conflict	1184	1	N → D in AAL91490. Ref.1
	Sequence conflict	1204	1	V → I in AAL91490. Ref.1
	Sequence conflict	1504	1	V → I in AAL91490. Ref.1
	Sequence conflict	1507	1	L → F in AAL91490. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q54TV2-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: B6AA767896850909	FASTA	1,509	170,937
	10 20 30 40 50 60 MVKQDPRDKS SYSPNLSIPI NNQEEPTLNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNK 70 80 90 100 110 120 NNNNNNIKHK DEENDFEDSI YQIAKEHEGE EDDEYFPIPL DELMPNHEND ELTKKIKQTR 130 140 150 160 170 180 PEDKTGLYVY CRNATYTVKH RENKKVKIKL LDDVSFFLRP KQMTLILGTP GCGKSTIFQM 190 200 210 220 230 240 LAGQLKDKHF EGELLFNGHP INHKNHHRDI SYVTQDDIHV PTLTVKETFR FALDCLGKKE 250 260 270 280 290 300 LTREEKQVSV DNCMKLLGLK HAENTLVGDN FIRGISGGQK KRVTIGVGVI KGSNLLLMDE 310 320 330 340 350 360 PTSGLDSSTS FEILSDVKKF VTYGYSPALI TLLQPSVQLT SLFDNLMIMS KGKICYFGPM 370 380 390 400 410 420 NRALGYFKKL GFACPSHNNP AEFFQEVVDA PERYSFIHPP KCKTSDDFVK AYRESDIYLE 430 440 450 460 470 480 LMEKMDANKD GIVDDNKPKV LVDSTAKELG MYPHGIGYQT KICLKRGFIM ISRNYYNFAT 490 500 510 520 530 540 RVFKGIFFGL LLGTLYWRIG HNQSGGMERF GLLFFIMTTI IFSSFAAVNS FFGERKVFYS 550 560 570 580 590 600 QKALHYYKTG AYFISSIICD IPAGLIEVAF FGPIVYWLAN LRPVFIRFVY FMILLFITDN 610 620 630 640 650 660 LSLSFAKMCA AISPTIEIAN VTASVILSIW LLFSGFTAPK NDIGGWWIWL YYISPYTWIF 670 680 690 700 710 720 QGLSINEFTY QAYGCKDSEL IPPRTPQNLL PYPEGFGGNQ VCQYTSGEQI MDAFGINNPD 730 740 750 760 770 780 YFKWIVYAIL GAYIVFFYSV CFFALKYLNF EDKKSKLAVK KLKKKKKVIV CKEDEEPNCK 790 800 810 820 830 840 VTTEALERVS DDNDDNADIS NYDDDTVIDM KSPLTSPNYN NNNNLSGSGN NIKRRKVKTP 850 860 870 880 890 900 STLSPMVNSP LTNLSPMVNT PSKNGNHSKQ KPISTSQKDI SSETGSYLQF KKLCYAVDVK 910 920 930 940 950 960 ADDPDNPKKK KSQRLQLLTD IDGYVKPGQM LALMGPSGAG KSTLLDVLAQ RKTGGHITGE 970 980 990 1000 1010 1020 ILINGKPPSE FTNRIRAYVE QMDVLPPTQT VREAIAFSAR CRLPPEVTKE EREIFVDKIV 1030 1040 1050 1060 1070 1080 EVLSLSSIKD LKIGVLGNGL SVSQRKRVNI GVELASNPEI LFLDEPTSGL DSGDAFKVID 1090 1100 1110 1120 1130 1140 VVNKIAKVMN RTVICTVHQP SAAIFEFFDQ LLLLKKGGET IYFGPLGNQS SVILDYCDKL 1150 1160 1170 1180 1190 1200 GMHIKPHINP ADFVMTLADE GKMVEGPNGE QEHLDAKKAY FESNICKKEY EIMEGQLIPD 1210 1220 1230 1240 1250 1260 DFVVKTYDSR FASSWMTQFR ALCMRSWLSR LRRPAIFVSN CLRSILLAVL LGTLFVRMDY 1270 1280 1290 1300 1310 1320 EQKDARSRVS LLFFSFLFAG MVAIGNIPTT VLERGVFYRE VTAGFYHSTA YMISYVLTSY 1330 1340 1350 1360 1370 1380 PFILSTGILY IIPTFWIAGL DSGRHSSKFW YCLFIFIITY IMYDAFALCL AVCLPNEVMA 1390 1400 1410 1420 1430 1440 STICGIGLSL ATLFGGFVIA RPNYPSAYYW CHYLDWLRYP LEASCTNEFT GLTFVCTNNK 1450 1460 1470 1480 1490 1500 GAVPIPIIEN GVQIAIKYYC PITNGDDFML TYGFHKFMRY IDIAAIFGYI FIFVGLSFWG FKKVRWLNR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary analyses of ABC transporters of Dictyostelium discoideum." Anjard C., Loomis W.F. Eukaryot. Cell 1:643-652(2002) [PubMed: 12456012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: AX4.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF482384 Genomic DNA. Translation: AAL91490.1. AAFI02000041 Genomic DNA. Translation: EAL66677.1.
RefSeq	XP_640709.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3391767.
KEGG	ddi:DDB_0215344.
Organism-specific databases
dictyBase	DDB0215344. abcG5.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase_core. IPR013525. ABC_2_trans. IPR003439. ABC_transporter-like. [Graphical view]
Pfam	PF01061. ABC2_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
ProDom	PD000006. ABC_transporter. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS51012. ABC_TM2. False negative. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ABCG5_DICDI

Accession

Primary (citable) accession number: Q54TV2
Secondary accession number(s): Q8T688

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	May 24, 2005
Last modified:	July 22, 2008
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)