Reviewed, UniProtKB/Swiss-Prot Q554S6 (ACT17_DICDI)

Names and origin

Protein names

Recommended name:
    Actin-17
Alternative name(s):
    Actin-2-sub 2

Gene names

Name:	act17
Synonyms:	act2-2
ORF Names:	DDB_0185125

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	374 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction By similarity.
Subcellular location	Cytoplasm › cytoskeletonBy similarity.
Sequence similarities	Belongs to the actin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Ligand	ATP-binding Nucleotide-binding
Molecular function	Structural protein
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 374	374	Actin-17
Experimental info
	Sequence conflict	13	1	N → K in AAR23116. Ref.3
	Sequence conflict	15	1	S → F in AAR23116. Ref.3
	Sequence conflict	35	1	I → N in AAR23116. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q554S6-1 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: F704388B42FC3C42	FASTA	374	41,571
	10 20 30 40 50 60 MECGDVQALV IDNGSSISKA GFAGDDAPRA VFPSIVGRQR YRDVMVGMGQ KDSYVGDEAQ 70 80 90 100 110 120 SKRGILNLKY PIERGIITNW DDMEKIWHHT FYNELRVAPE EHPIHLTLSP SSSKANREKM 130 140 150 160 170 180 TQIMFETFSN PAMYISIQSA LSLYASGLTT GIVIDSGDGV SHTVPILEGH SINHAISRLD 190 200 210 220 230 240 LAGNDLTDYL GKLLSGRGYP FISIDETEIV RDIKEKLSYI TLDFQNEIKI VSSALEKSYE 250 260 270 280 290 300 LPDGKVISIG NELFRCPEAL FQPSFLGMES AGIHETTYNS IMKCDVDIRK DLYDNVVLSG 310 320 330 340 350 360 GTTMFPGIAD RMNKELTALA PSTMKIKIIA PPERKYSVWI GGSMLSSLST FQQMWISKEE 370 YDESGPSIVH RKCF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[3]	"Unusual nucleotide sequences at the 5' end of actin genes in Dictyostelium discoideum." Firtel R.A., Timm R., Kimmel A.R., McKeown M. Proc. Natl. Acad. Sci. U.S.A. 76:6206-6210(1979) [PubMed: 293714] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-41.
[4]	"Evidence for sub-families of actin genes in Dictyostelium as determined by comparisons of 3' end sequences." McKeown M., Firtel R.A. J. Mol. Biol. 151:593-606(1981) [PubMed: 6276562] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 320-374. Strain: A3.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC116956 Genomic DNA. Translation: AAL92611.1. AAFI02000012 Genomic DNA. Translation: EAL69958.1. J01268 Genomic DNA. Translation: AAR23116.1. K02955 Genomic DNA. Translation: AAR23117.1.
RefSeq	XP_644247.1.
3D structure databases
SMR	Q554S6. Positions 5-374.
ModBase	Search...
Genome annotation databases
GeneID	3395434.
KEGG	ddi:DDB_0185125.
Organism-specific databases
dictyBase	DDB0185125. act17.
Family and domain databases
InterPro	IPR004001. Actin_CS. IPR004000. Actin_like. [Graphical view]
PANTHER	PTHR11937. Actin_like. 1 hit.
Pfam	PF00022. Actin. 1 hit. [Graphical view]
PRINTS	PR00190. ACTIN.
SMART	SM00268. ACTIN. 1 hit. [Graphical view]
PROSITE	PS00406. ACTINS_1. 1 hit. PS00432. ACTINS_2. 1 hit. [Graphical view]
ProDom	Q554S6. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ACT17_DICDI

Accession

Primary (citable) accession number: Q554S6
Secondary accession number(s): Q6LEI3, Q8T299

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	May 2, 2006
Last modified:	July 22, 2008
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)