Reviewed, UniProtKB/Swiss-Prot Q556N5 (ADRM1_DICDI)

Names and origin

Protein names

Recommended name:
    Protein ADRM1 homolog

Gene names

Name:	adrm1-1
ORF Names:	DDB_0233908
AND
Name:	adrm1-2
ORF Names:	DDB_0238204

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	287 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Recruits the deubiquitinating enzyme uchl5 at the 26S proteasome and promotes its activity By similarity. Plays a role in the transition from growth to differentiation.
Subunit structure	Interacts with phg2.
Subcellular location	CytoplasmBy similarity. NucleusBy similarity.
Sequence similarities	Belongs to the ADRM1 family.
Caution	The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus Proteasome
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	RNA elongation from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB cell differentiation Ref.3 Inferred from mutant phenotype. Source: UniProtKB cell growth Ref.3 Inferred from mutant phenotype. Source: UniProtKB proteasome assembly Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	proteasome complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	proteasome activator activity Inferred from sequence or structural similarity. Source: UniProtKB protein binding Ref.3 Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 287	287	Protein ADRM1 homolog

Sequences

	Sequence		Length	Mass (Da)
	Q556N5-1 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: 0EA944D0229C63EE	FASTA	287	32,349
	10 20 30 40 50 60 MNRPPQDVEF KAGKAKLTGT TVTSDSRKGY LKFGVTPEGL TCVQWRPRDS SAYEDEFYFA 70 80 90 100 110 120 PGESKFIKVP ACKTGRMYYL NFSGSDQKEF YWLQEANVEG DAKIEKALKV IESYIPDDDD 130 140 150 160 170 180 DEEMVVDTPP PTTTIKQEPP KNPTINEVSL SQPKPTTTPP PSATNLDFIK DLFSNLPTQP 190 200 210 220 230 240 KQPQITLGKI LTAENLIPFL RENPEIKKDL IQYLPEEYQK DENMINEVLH SAQFLQSIET 250 260 270 280 LDYAIHEGHG PEIVSLLGYE PSIASQRGVE GFLTNIQEGT NKKKNNK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[3]	"A Phg2-Adrm1 pathway participates in the nutrient-controlled developmental response in Dictyostelium." Cherix N., Froquet R., Charette S.J., Blanc C., Letourneur F., Cosson P. Mol. Biol. Cell 17:4982-4987(2006) [PubMed: 16987957] [Abstract] Cited for: INTERACTION WITH PHG2, FUNCTION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC116984 Genomic DNA. Translation: AAM33193.2. AAFI02000011 Genomic DNA. Translation: EAL70480.1. AAFI02000009 Genomic DNA. Translation: EAL70949.1.
RefSeq	XP_644405.1. XP_645008.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3395486. 3396234.
KEGG	ddi:DDBDRAFT_0167941. ddi:DDBDRAFT_0217459.
Organism-specific databases
dictyBase	DDB0233908. adrm1-1. DDB0238204. adrm1-2.
Family and domain databases
InterPro	IPR006773. ARM_1. [Graphical view]
PANTHER	PTHR12225. ARM_1. 1 hit.
Pfam	PF04683. ARM_1. 1 hit. [Graphical view]
ProDom	Q556N5. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ADRM1_DICDI

Accession

Primary (citable) accession number: Q556N5
Secondary accession number(s): Q8MYI8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 2, 2006
Last modified:	July 22, 2008
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)