Reviewed, UniProtKB/Swiss-Prot Q55EU6 (ACT23_DICDI)

Names and origin

Protein names

Recommended name:
    Putative actin-23

Gene names

Name:	act23
ORF Names:	DDB_0220461

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction By similarity.
Subcellular location	Cytoplasm › cytoskeletonBy similarity.
Sequence similarities	Belongs to the actin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Ligand	ATP-binding Nucleotide-binding
Molecular function	Structural protein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	phagocytic vesicle Ref.2 Inferred from direct assay. Source: dictyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 358	358	Putative actin-23

Sequences

	Sequence		Length	Mass (Da)
	Q55EU6-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: E3ADB69D28AA6821	FASTA	358	39,964
	10 20 30 40 50 60 MCKAGFAGDD APCTVFPSIV GRPRHTGVMV GMCQKGSYVG DEAQSKRGIL TLKYPIEHGI 70 80 90 100 110 120 VTNWDDMEKI WHHTFYNELR VAPEEHPVLL TEAPLNPKAN REKMTQIMFE TFNTPAMYVA 130 140 150 160 170 180 IQAVLSLYAS GRTTGIVMDS GDGVSHTVPI YEGYALPHAI LRLDLAGRDL TDYLMKILTE 190 200 210 220 230 240 RGYSFTTTAE REIVRDIKEK LAYVALDFEA EMQTATSSAL EKSYELPDGQ VITIGNERFR 250 260 270 280 290 300 CPEALFQPSF LGMESAGIHE TTYNSIMKCD VDIRKDLYGN VVLSGGTTMF PGIADRMNKE 310 320 330 340 350 LTALAPSTMK IKIIAPPERK YSVWIGSILA SLSTFQQMWI SKEEYDESGP SIVHRKCF

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

[2]

"Proteomics fingerprinting of phagosome maturation and evidence for the role of a Galpha during uptake." Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M., Soldati T. Mol. Cell. Proteomics 5:2228-2243(2006) [PubMed: 16926386] [Abstract] Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000004 Genomic DNA. Translation: EAL72961.1.
RefSeq	XP_646924.1.
3D structure databases
SMR	Q55EU6. Positions 1-358.
ModBase	Search...
Genome annotation databases
GeneID	3397993.
KEGG	ddi:DDB_0220461.
Organism-specific databases
dictyBase	DDB0220461. act23.
Family and domain databases
InterPro	IPR004001. Actin_CS. IPR004000. Actin_like. [Graphical view]
PANTHER	PTHR11937. Actin_like. 1 hit.
Pfam	PF00022. Actin. 1 hit. [Graphical view]
PRINTS	PR00190. ACTIN.
SMART	SM00268. ACTIN. 1 hit. [Graphical view]
PROSITE	PS00406. ACTINS_1. 1 hit. PS00432. ACTINS_2. 1 hit. PS01132. ACTINS_ACT_LIKE. 1 hit. [Graphical view]
ProDom	Q55EU6. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ACT23_DICDI

Accession

Primary (citable) accession number: Q55EU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	May 24, 2005
Last modified:	July 22, 2008
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)