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Reviewed, UniProtKB/Swiss-Prot Q56215 (MUTS_THEAQ)

Last modified November 25, 2008. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    DNA mismatch repair protein mutS
Gene names
Name: mutS
OrganismThermus aquaticus
Taxonomic identifier271 [NCBI]
Taxonomic lineageBacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

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Protein attributes

Sequence length811 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

Sequence similarities

Belongs to the DNA mismatch repair mutS family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 811811DNA mismatch repair protein mutS
PRO_0000115156

Regions

Nucleotide binding583 – 5908ATP Potential

Secondary structure

1 ....................................................................................................................... 811
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
Q56215-1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 43A5E5296A333515

FASTA81190,627
        10         20         30         40         50         60 
MEGMLKGEGP GPLPPLLQQY VELRDQYPDY LLLFQVGDFY ECFGEDAERL ARALGLVLTH 

        70         80         90        100        110        120 
KTSKDFTTPM AGIPLRAFEA YAERLLKMGF RLAVADQVEP AEEAEGLVRR EVTQLLTPGT 

       130        140        150        160        170        180 
LLQESLLPRE ANYLAAIATG DGWGLAFLDV STGEFKGTVL KSKSALYDEL FRHRPAEVLL 

       190        200        210        220        230        240 
APELLENGAF LDEFRKRFPV MLSEAPFEPE GEGPLALRRA RGALLAYAQR TQGGALSLQP 

       250        260        270        280        290        300 
FRFYDPGAFM RLPEATLRAL EVFEPLRGQD TLFSVLDETR TAPGRRLLQS WLRHPLLDRG 

       310        320        330        340        350        360 
PLEARLDRVE GFVREGALRE GVRRLLYRLA DLERLATRLE LGRASPKDLG ALRRSLQILP 

       370        380        390        400        410        420 
ELRALLGEEV GLPDLSPLKE ELEAALVEDP PLKVSEGGLI REGYDPDLDA LRAAHREGVA 

       430        440        450        460        470        480 
YFLELEERER ERTGIPTLKV GYNAVFGYYL EVTRPYYERV PKEYRPVQTL KDRQRYTLPE 

       490        500        510        520        530        540 
MKEKEREVYR LEALIRRREE EVFLEVRERA KRQAEALREA ARILAELDVY AALAEVAVRY 

       550        560        570        580        590        600 
GYVRPRFGDR LQIRAGRHPV VERRTEFVPN DLEMAHELVL ITGPNMAGKS TFLRQTALIA 

       610        620        630        640        650        660 
LLAQVGSFVP AEEAHLPLFD GIYTRIGASD DLAGGKSTFM VEMEEVALIL KEATENSLVL 

       670        680        690        700        710        720 
LDEVGRGTSS LDGVAIATAV AEALHERRAY TLFATHYFEL TALGLPRLKN LHVAAREEAG 

       730        740        750        760        770        780 
GLVFYHQVLP GPASKSYGVE VAAMAGLPKE VVARARALLQ AMAARREGAL DAVLERLLAL 

       790        800        810 
DPDRLTPLEA LRLLQELKAL ALGAPLDTMK G

« Hide

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References

[1]"Identification and characterization of a thermostable MutS homolog from Thermus aquaticus."
Biswas I., Hsieh P.
J. Biol. Chem. 271:5040-5048(1996) [PubMed: 8617781] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: YT1.
+Additional computationally mapped references.

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Cross-references

Sequence databases

U33117 Genomic DNA. Translation: AAC43637.1.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1EWQX-ray2.20A/B1-765[»]
1EWRX-ray3.19A/B117-765[»]
1FW6X-ray2.70A/B1-768[»]
1NNEX-ray3.11A/B1-765[»]
ModBaseSearch...

Family and domain databases

HAMAPMF_00096.
[Tree]
InterProIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007860. DNA_mismatch_repair_MutS_connt.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
[Graphical view]
Gene3DG3DSA:3.30.420.110. DNA_mismatch_repair_MutS_connt. 1 hit.
G3DSA:3.40.1170.10. DNA_mismatch_repair_MutS_N. 1 hit.
PANTHERPTHR11361. MutS_C. 1 hit.
PfamPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
ProDomPD001263. MutS_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
TIGRFAMsTIGR01070. mutS1. 1 hit.
PROSITEPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameMUTS_THEAQ
AccessionPrimary (citable) accession number: Q56215
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 25, 2008
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents