Reviewed, UniProtKB/Swiss-Prot Q562R1 (ACTBL_HUMAN)

Names and origin

Protein names

Recommended name:
    Beta-actin-like protein 2
Alternative name(s):
    Kappa-actin

Gene names

Name:

ACTBL2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells By similarity.
Subunit structure	Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others By similarity. Interacts with PFN1 and PFDN1.
Subcellular location	Cytoplasm › cytoskeletonBy similarity.
Miscellaneous	In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
Sequence similarities	Belongs to the actin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Ligand	ATP-binding Nucleotide-binding
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from electronic annotation. Source: InterPro structural molecule activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 376	376	Beta-actin-like protein 2		PRO_0000318849
Experimental info
	Sequence conflict	121	1	T → I in AAX82242. Ref.2
	Sequence conflict	135	1	V → A in AAX82260. Ref.2
	Sequence conflict	162	1	H → L in AAX82259. Ref.2
	Sequence conflict	163	1	I → T in AAX82193. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q562R1-1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: 6095D374964D71DA	FASTA	376	42,003
	10 20 30 40 50 60 MTDNELSALV VDNGSGMCKA GFGGDDAPRA VFPSMIGRPR HQGVMVGMGQ KDCYVGDEAQ 70 80 90 100 110 120 SKRGVLTLKY PIEHGVVTNW DDMEKIWYHT FYNELRVAPD EHPILLTEAP LNPKINREKM 130 140 150 160 170 180 TQIMFEAFNT PAMYVAIQAV LSLYASGRTT GIVMDSGDGV THIVPIYEGY ALPHAILRLD 190 200 210 220 230 240 LAGRDLTDYL MKILTERGYN FTTTAEREIV RDVKEKLCYV ALDFEQEMVR AAASSSPERS 250 260 270 280 290 300 YELPDGQVIT IGNERFRCPE AIFQPSFLGI ESSGIHETTF NSIMKCDVDI RKDLYANTVL 310 320 330 340 350 360 SGGSTMYPGI ADRMQKEIIT LAPSTMKIKI IAPPERKYSV WIGGSILASL STFQQMWISK 370 QEYDEAGPPI VHRKCF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	The German cDNA consortium Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Endometrial tumor.
[2]	"Identification of a novel actin isoform in hepatocellular carcinoma." Chang K.-W., Yang P.-Y., Lai H.-Y., Yeh T.-S., Chen T.-C., Yeh C.-T. Hepatol. Res. 36:33-39(2006) [PubMed: 16824795] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 85-187, INTERACTION WITH PFN1 AND PFDN1. Tissue: Hepatoma.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX648504 mRNA. No translation available. AY970384 Genomic DNA. Translation: AAX82193.1. AY970433 Genomic DNA. Translation: AAX82242.1. AY970451 Genomic DNA. Translation: AAX82259.1. AY970452 Genomic DNA. Translation: AAX82260.1.
RefSeq	NP_001017992.1.
UniGene	Hs.482167
3D structure databases
SMR	Q562R1. Positions 1-103.
ModBase	Search...
Proteomic databases
PeptideAtlas	Q562R1.
Genome annotation databases
Ensembl	ENSG00000169067. Homo sapiens. [Contig view]
GeneID	345651.
KEGG	hsa:345651.
Organism-specific databases
HGNC	HGNC:17780. ACTBL2.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q562R1.
HOVERGEN	Q562R1.
Gene expression databases
ArrayExpress	Q562R1.
CleanEx	HS_ACTBL2.
Family and domain databases
InterPro	IPR004001. Actin_CS. IPR004000. Actin_like. [Graphical view]
PANTHER	PTHR11937. Actin_like. 1 hit.
Pfam	PF00022. Actin. 1 hit. [Graphical view]
PRINTS	PR00190. ACTIN.
SMART	SM00268. ACTIN. 1 hit. [Graphical view]
PROSITE	PS00406. ACTINS_1. 1 hit. PS00432. ACTINS_2. 1 hit. PS01132. ACTINS_ACT_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	98897.

Entry information

Entry name

ACTBL_HUMAN

Accession

Primary (citable) accession number: Q562R1
Secondary accession number(s): Q562R2, Q562S9, Q562X8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	November 25, 2008
This is version 22 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)