Reviewed, UniProtKB/Swiss-Prot Q57DY4 (NRDR_BRUAB)

Names and origin

Protein names

Recommended name:
    Transcriptional repressor nrdR

Gene names

Name:	nrdR
Ordered Locus Names:	BruAb1_0782

Organism

Brucella abortus [Complete proteome] [HAMAP]

Taxonomic identifier

235 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes By similarity.
Cofactor	Binds 1 zinc ion By similarity.
Sequence similarities	Belongs to the nrdR family. Contains 1 ATP-cone domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Domain	Zinc-finger
Ligand	ATP-binding DNA-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Repressor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: UniProtKB-KW transcription repressor activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 158	158	Transcriptional repressor nrdR		PRO_0000230856
Regions
	Domain	49 – 139	91	ATP-cone
	Zinc finger	3 – 34	32	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q57DY4-1 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 04CC792029B47D56	FASTA	158	17,933
	10 20 30 40 50 60 MRCPYCQSED TQVKDSRPAE DGAVIRRRRV CSVCGGRFTT FERVQLRDLM VVKKSGRRVP 70 80 90 100 110 120 FDRDKLTRSI EVALRKRDVD SERVERAISG IVRQLESAGE AEVTSDEIGR LAMDALKGID 130 140 150 DIAYIRFASV YRNFSKAVDF HNVIDELTVS ETGDNLET

References

[1]

"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis." Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C. J. Bacteriol. 187:2715-2726(2005) [PubMed: 15805518] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 9-941 / Biovar 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017223 Genomic DNA. Translation: AAX74150.1.
RefSeq	YP_221511.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3339542.
GenomeReviews	Gene locus BruAb1_0782 in contig AE017223_GR.
KEGG	bmb:BruAb1_0782.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q57DY4.
Enzyme and pathway databases
BioCyc	BABO262698:BRUAB1_0782-MON.
Family and domain databases
HAMAP	MF_00440. [Tree]
InterPro	IPR005144. ATP-cone. IPR003796. RNR_NrdR-like. [Graphical view]
Pfam	PF03477. ATP-cone. 1 hit. [Graphical view]
TIGRFAMs	TIGR00244. RNR_NrdR-like. 1 hit.
PROSITE	PS51161. ATP_CONE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NRDR_BRUAB

Accession

Primary (citable) accession number: Q57DY4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	May 10, 2005
Last modified:	November 4, 2008
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)