Reviewed, UniProtKB/Swiss-Prot Q57E41 (UVRC_BRUAB)

Names and origin

Protein names

Recommended name:
    UvrABC system protein C
      Short name=Protein uvrC
Alternative name(s):
    Excinuclease ABC subunit C

Gene names

Name:	uvrC
Ordered Locus Names:	BruAb1_0718

Organism

Brucella abortus [Complete proteome] [HAMAP]

Taxonomic identifier

235 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	627 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision By similarity.
Subunit structure	Interacts with uvrB in an incision complex By similarity.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the uvrC family. Contains 1 UVR domain.

Ontologies

Keywords
Biological process	DNA damage DNA excision DNA repair SOS response
Cellular component	Cytoplasm
Molecular function	Excision nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	SOS response Inferred from electronic annotation. Source: HAMAP nucleotide-excision repair Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP excinuclease repair complex Inferred from electronic annotation. Source: InterPro
Molecular function	excinuclease ABC activity Inferred from electronic annotation. Source: HAMAP sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 627	627	UvrABC system protein C		PRO_0000227405
Regions
	Domain	210 – 245	36	UVR

Sequences

	Sequence		Length	Mass (Da)
	Q57E41-1 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: E5838917CC3FBE03	FASTA	627	69,595
	10 20 30 40 50 60 MPDTAGLSGP DIINAFVKRL PNNPGVYRMF NSDGGVLYVG KARNLKKRVS NYARGIGHSN 70 80 90 100 110 120 RITRMIRETV TMEFVVTRTE TEALLLEANL IKRLRPRFNV LMRDDKSFPY ILLTGGHRAP 130 140 150 160 170 180 GIFKHRGARS RKGDYFGPFA SAGAVGRTIN ALQRAFLLRT CTDSVFETRT RPCLLYQIKR 190 200 210 220 230 240 CSAPCTYEIS DEDYAGLVAE AKAFLSGKSQ SVKDHLAAAM QAASADLDFE HAAVYRDRLA 250 260 270 280 290 300 ALSHVQSHQG INPQTVEEAD VFAIHQEGGM TCIQVFFFRT GQNWGNRAYF PKADSSLGPA 310 320 330 340 350 360 EVLGAFLSQF YDDKPCPKLV LLSETVEEQS LITEALSTRA GHKVQVSVPQ RGEKKELVQH 370 380 390 400 410 420 ALTNAREALG RRLAETSSQA RLLQGLAETF GLPRAPRRIE VYDNSHIMGT NAVGGMIVAG 430 440 450 460 470 480 PEGFVKNQYR KFNIRSTDIT PGDDFGMMRE VIERRFSRLV KEHGTPAGEV KNPDAFPAWP 490 500 510 520 530 540 DVILIDGGQG QVGAVRQILG EMGISDLVTA IGIAKGVDRE AGRERFFMEG KQPFTLPPRD 550 560 570 580 590 600 PVLYFIQRLR DEAHRFAIGT HRARRKKEIV RNPLDEIAGI GPTRKRALLH HFGTAKAVSR 610 620 AAVEDLMQID GISEAMARAI HDHFRDK

References

[1]

"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis." Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C. J. Bacteriol. 187:2715-2726(2005) [PubMed: 15805518] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 9-941 / Biovar 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017223 Genomic DNA. Translation: AAX74093.1.
RefSeq	YP_221454.2.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3339328.
GenomeReviews	Gene locus BruAb1_0718 in contig AE017223_GR.
KEGG	bmb:BruAb1_0718.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q57E41.
Enzyme and pathway databases
BioCyc	BABO262698:BRUAB1_0718-MON.
Family and domain databases
HAMAP	MF_00203. [Tree]
InterPro	IPR000445. HhH. IPR003583. HHH1_bd. IPR001943. UvrB/C. IPR004791. UvrC_ABC. IPR001162. UvrC_C. IPR000305. UvrC_N. [Graphical view]
Pfam	PF01541. GIY-YIG. 1 hit. PF00633. HHH. 1 hit. PF02151. UVR. 1 hit. PF08459. UvrC_HhH_N. 1 hit. [Graphical view]
ProDom	PD005870. UvrC_C. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00465. GIYc. 1 hit. SM00278. HhH1. 2 hits. [Graphical view]
TIGRFAMs	TIGR00194. uvrC. 1 hit.
PROSITE	PS50151. UVR. 1 hit. PS50164. UVRC_1. 1 hit. PS50165. UVRC_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UVRC_BRUAB

Accession

Primary (citable) accession number: Q57E41

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	May 10, 2005
Last modified:	November 25, 2008
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)