Reviewed, UniProtKB/Swiss-Prot Q57F56 (OTC_BRUAB)

Names and origin

Protein names

Recommended name:
    Ornithine carbamoyltransferase
      Short name=OTCase
    EC=2.1.3.3

Gene names

Name:	argF
Ordered Locus Names:	BruAb1_0328

Organism

Brucella abortus [Complete proteome] [HAMAP]

Taxonomic identifier

235 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3.
Subcellular location	CytoplasmProbable.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Ornithine carbamoyltransferase		PRO_1000065077
Regions
	Region	57 – 61	5	Carbamoyl phosphate binding By similarity
	Region	264 – 267	4	Ornithine binding By similarity
Sites
	Binding site	108	1	Carbamoyl phosphate By similarity
	Binding site	135	1	Carbamoyl phosphate By similarity
	Site	32	1	Important for structural integrity By similarity
	Site	148	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q57F56-1 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 60DBB4EC456B939C	FASTA	312	34,239
	10 20 30 40 50 60 MANDNGIKHF IDLSTVPATE LRAILEDAKA RKARLKAGEV ERPYAGKVLA MIFEKLSTRT 70 80 90 100 110 120 RVSFDVGMRQ LGGETIMLTG SEMQLGRSET IADTAKVLSR YVDAIMIRTT AHERMLELAE 130 140 150 160 170 180 YATVPVINAL TDDTHPCQIM ADVLTYEEHR GPIKGKTFAW MGDGNNVLHS LVEAAARFDF 190 200 210 220 230 240 NVNIATPKGS EPKSQYIDWA RANGAGIMST TDPEKAASGA DCIVTDTWVS MGQEDHARGH 250 260 270 280 290 300 NVFIPYQVNA NLMAKADPKA LFMHCLPAHR GEEVTDEVID GPQSVVFDEA ENRLHAQKAI 310 LAWCLQDRGL GA

References

[1]

"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis." Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C. J. Bacteriol. 187:2715-2726(2005) [PubMed: 15805518] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 9-941 / Biovar 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017223 Genomic DNA. Translation: AAX73728.1.
RefSeq	YP_221089.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3339044.
GenomeReviews	Gene locus BruAb1_0328 in contig AE017223_GR.
KEGG	bmb:BruAb1_0328.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q57F56.
Enzyme and pathway databases
BioCyc	BABO262698:BRUAB1_0328-MON.
Family and domain databases
HAMAP	MF_01109. [Tree]
InterPro	IPR006130. Asp/Orn_carbamoyltranf. IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002292. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
TIGRFAMs	TIGR00658. orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTC_BRUAB

Accession

Primary (citable) accession number: Q57F56

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	May 10, 2005
Last modified:	November 25, 2008
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)