Reviewed, UniProtKB/Swiss-Prot Q57FG5 (THIG_BRUAB)

Names and origin

Protein names

Recommended name:
    Thiazole biosynthesis protein thiG

Gene names

Name:	thiG
Ordered Locus Names:	BruAb1_0210

Organism

Brucella abortus [Complete proteome] [HAMAP]

Taxonomic identifier

235 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Required for the synthesis of the thiazole moiety of thiamine By similarity.
Cofactor	FMN Potential.
Pathway	Cofactor biosynthesis; thiamine pyrophosphate biosynthesis. HAMAP MF_00443
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the thiG family.

Ontologies

Keywords
Biological process	Thiamine biosynthesis
Cellular component	Cytoplasm
Ligand	FMN Flavoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	thiamin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	catalytic activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 256	256	Thiazole biosynthesis protein thiG HAMAP MF_00443		PRO_0000162796

Sequences

	Sequence		Length	Mass (Da)
	Q57FG5-1 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: B4BB05AAAF6E0510	FASTA	256	27,321
	10 20 30 40 50 60 MLEFYGKRFE SRLLLGTAQY PSPSILADAV RASLSRIVTV SLRRESGEAR AGQDFWALIK 70 80 90 100 110 120 ALGVAVLPNT AGCHTPREAI TTAHMAREVF GTNWIKLEVI GDTDTLQPDP FGLVEAARIL 130 140 150 160 170 180 CDEGFEVFPY MNDDLIVAER LIEAGCKVLM PWGAPIGSGR GLNNPYALKT MRAHFPDIPL 190 200 210 220 230 240 VVDAGIGVPS HAAAAMELGF DAVLINTAVA KAGDPAAMAR AFALAVEAGR LAYEADPIEA 250 RDMASPSTPL LGKAFL

References

[1]

"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis." Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C. J. Bacteriol. 187:2715-2726(2005) [PubMed: 15805518] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 9-941 / Biovar 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017223 Genomic DNA. Translation: AAX73619.1.
RefSeq	YP_220980.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3339065.
GenomeReviews	Gene locus BruAb1_0210 in contig AE017223_GR.
KEGG	bmb:BruAb1_0210.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q57FG5.
Enzyme and pathway databases
BioCyc	BABO262698:BRUAB1_0210-MON.
Family and domain databases
HAMAP	MF_00443. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR008867. ThiG. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF05690. ThiG. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THIG_BRUAB

Accession

Primary (citable) accession number: Q57FG5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	May 10, 2005
Last modified:	November 25, 2008
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)