Reviewed, UniProtKB/Swiss-Prot Q57FQ9 (PNCB_BRUAB)

Names and origin

Protein names

Recommended name:
    Nicotinate phosphoribosyltransferase
      Short name=NAPRTase
    EC=2.4.2.11

Gene names

Name:	pncB
Ordered Locus Names:	BruAb1_0109

Organism

Brucella abortus [Complete proteome] [HAMAP]

Taxonomic identifier

235 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate ribonucleotide from nicotinate: step 1/1.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP nicotinate nucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	nicotinate phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 434	434	Nicotinate phosphoribosyltransferase		PRO_1000024996

Sequences

	Sequence		Length	Mass (Da)
	Q57FQ9-1 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: A11BE6474B58F0C4	FASTA	434	49,909
	10 20 30 40 50 60 MAKTDLARRV YNHTWKLDPI IRSLLDTDFY KLLMLQMIWG LYPRVDATFS LINRTSSVRL 70 80 90 100 110 120 ADEIDEGELR AQLDHARTLR FSKKEMIWLA GNTFYGRKQI FQPEFLAWLH DFQLPEYELR 130 140 150 160 170 180 RKDGQYELHF HGPWTHTTMW EIPALAIINE LRSRAAMKNL GPFSLDVLYA RAKAKMWSKV 190 200 210 220 230 240 ERLRQLPDLK ISDFGTRRRH SFLWQRWCVE ALKEGIGSAF TGTSNVLLAM DTDLEALGTN 250 260 270 280 290 300 AHELPMVLAA LAKTDDELRS APYRVLQDWN RYYGGNLLIV LPDAFGTAAF LRNAPDWVAD 310 320 330 340 350 360 WTGFRPDSAP PIEGGERIIE WWKSKGKDPR EKLLIFSDAL DVDTIEETYR HFEGRVRMGF 370 380 390 400 410 420 GWGTNLTNDF AGCAPQSIDG LKAISLVCKV TDANGHPAVK LSDNPQKATG DPKEVARYLR 430 FFGNEERVEQ LVRV

References

[1]

"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis." Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C. J. Bacteriol. 187:2715-2726(2005) [PubMed: 15805518] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 9-941 / Biovar 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017223 Genomic DNA. Translation: AAX73525.1.
RefSeq	YP_220886.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3340770.
GenomeReviews	Gene locus BruAb1_0109 in contig AE017223_GR.
KEGG	bmb:BruAb1_0109.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q57FQ9.
Enzyme and pathway databases
BioCyc	BABO262698:BRUAB1_0109-MON.
Family and domain databases
HAMAP	MF_00570. [Tree]
InterPro	IPR006406. Nic_PRibTrfase. IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. [Graphical view]
PANTHER	PTHR11098:SF1. NAPRTase. 1 hit.
Pfam	PF04095. NAPRTase. 1 hit. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
TIGRFAMs	TIGR01514. NAPRTase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PNCB_BRUAB

Accession

Primary (citable) accession number: Q57FQ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 10, 2005
Last modified:	November 25, 2008
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)