Reviewed, UniProtKB/Swiss-Prot Q59VP0 (BST1_CANAL)

Names and origin

Protein names

Recommended name:
    GPI inositol-deacylase
    EC=3.1.-.-

Gene names

Name:	BST1
ORF Names:	CaO19.1053, CaO19.8655

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins By similarity.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane proteinBy similarity.
Miscellaneous	Lacks the C-terminal half of the classical GPI inositol-deacylases.
Sequence similarities	Belongs to the GPI inositol-deacylase family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	GPI anchor metabolic process Inferred from electronic annotation. Source: InterPro intracellular protein transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW intrinsic to endoplasmic reticulum membrane Inferred from electronic annotation. Source: InterPro
Molecular function	hydrolase activity, acting on ester bonds Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 390	390	GPI inositol-deacylase		PRO_0000277632
Regions
	Transmembrane	21 – 41	21	Potential
	Transmembrane	354 – 374	21	Potential
Sites
	Active site	202	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q59VP0-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: FC626E0B3230B55D	FASTA	390	44,325
	10 20 30 40 50 60 MLSKRLFPYS NLFPRSRKYK FIVYFIICLT IIISALGVYL YSIPIVSPNQ PQCDMVWMSP 70 80 90 100 110 120 SYARIRAFDE THTKYASKYN LYLYREQDVD KMPNENENED GNEGFTSLDG IPALFIHGNA 130 140 150 160 170 180 GSFEQVRSIA ARCSEMYYTD GKFKEKYPHA RNIDFFTADF NEELSAFKGL RDQVEYVTQA 190 200 210 220 230 240 ISFIVDLYPQ NPNRNIILIG HSMGGLVARI AASRQQHESN VDIILTLATP HSDPFPWLPK 250 260 270 280 290 300 TSDFPDEVGL ISIYSSVDLM VPPSVVTPKS KSDHFFSVDA AKLLGVPIDH QGIVWCGQLR 310 320 330 340 350 360 EKLSEALIGI SGLNTLQDRM KVFKKIFSGD RKELGPTPIF GLAKLKLKLL QSWVHLLSLT 370 380 390 IFALKWTIIV LAIIQLRKVY TKFNNPPPTH

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000121 Genomic DNA. Translation: EAK94553.1. AACQ01000120 Genomic DNA. Translation: EAK94599.1.
RefSeq	XP_713657.1. XP_713702.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3644636. 3644717.
KEGG	cal:CaO19.1053. cal:CaO19.8655.
Organism-specific databases
CGD	CAL0001187. orf19.1053.
Family and domain databases
InterPro	IPR008262. Lipase_AS. IPR012908. PGAP1. [Graphical view]
Pfam	PF07819. PGAP1. 1 hit. [Graphical view]
PROSITE	PS00120. LIPASE_SER. 1 hit. Uncertain. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BST1_CANAL

Accession

Primary (citable) accession number: Q59VP0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	April 26, 2005
Last modified:	November 25, 2008
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)