Reviewed, UniProtKB/Swiss-Prot Q59VY1 (ATG5_CANAL)

Names and origin

Protein names

Recommended name:
    Autophagy protein 5

Gene names

Name:	ATG5
ORF Names:	CaO19.3677, CaO19.11161

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in cytoplasm to vacuole transport (Cvt) and autophagy vesicles formation. May be required for ATG8 association to the vesicle membranes By similarity.
Subcellular location	CytoplasmBy similarity. Membrane; Peripheral membrane proteinBy similarity.
Post-translational modification	Conjugated to ATG12; which is essential for autophagy By similarity.
Sequence similarities	Belongs to the ATG5 family.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm Membrane
PTM	Ubl conjugation
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Autophagy protein 5		PRO_0000219000
Amino acid modifications
	Cross-link	148		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ATG12) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q59VY1-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 1A0D70B03B064FC0	FASTA	278	32,189
	10 20 30 40 50 60 MNDIDNLAEI KKKLWNGSIN VKILLNIEDQ IIEYLLTIPR NSYFPTVFPQ LIRYFQNFIT 70 80 90 100 110 120 TIELSKVPIW LEFEEVPLKW NLPVGVLYDY LYLPALLNDH DLGCWTISMK YEPVYPIEYI 130 140 150 160 170 180 ISFNEKLAGD GQIDYMKTMN RILMNQLKQS CFVLNGTAKP IMQLSEANTN QLWKSLISRN 190 200 210 220 230 240 LGDFNVLNKK IIKTIDRIPV KIYIAGSPIV VQAPISKDQT LQEILSLHTP NLSSSSSSMS 250 260 270 HPYIQGIDVT SLMNQSIREI WQLFKHLDNF LYITLIIL

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000118 Genomic DNA. Translation: EAK94668.1. AACQ01000119 Genomic DNA. Translation: EAK94634.1.
RefSeq	XP_713737.1. XP_713771.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3644593. 3644619.
KEGG	cal:CaO19.11161. cal:CaO19.3677.
Organism-specific databases
CGD	CAL0000453. orf19.3677.
Family and domain databases
InterPro	IPR007239. Autophagy_prot_5. [Graphical view]
PANTHER	PTHR13040. APG5. 1 hit.
Pfam	PF04106. APG5. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG5_CANAL

Accession

Primary (citable) accession number: Q59VY1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	April 26, 2005
Last modified:	November 25, 2008
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)