Reviewed, UniProtKB/Swiss-Prot Q59WG7 (BIG1_CANAL)

Names and origin

Protein names

Recommended name:
    Protein BIG1

Gene names

Name:	BIG1
ORF Names:	CaO19.2334, CaO19.9870

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Required for normal beta-1,6-glucan synthesis, for hyphal morphogenesis, adhesion and virulence. Ref.2
Subcellular location	Endoplasmic reticulum membrane; Single-pass type I membrane protein. Ref.2
Post-translational modification	N-glycosylated. Ref.2
Miscellaneous	Present with 3460 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the BIG1 family.

Ontologies

Keywords
Biological process	Cell wall biogenesis/degradation
Cellular component	Endoplasmic reticulum Membrane
Domain	Signal Transmembrane
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 322	306	Protein BIG1		PRO_0000277849
Regions
	Topological domain	17 – 274	258	Lumenal Potential
	Transmembrane	275 – 295	21	Potential
	Topological domain	296 – 322	27	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	45	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q59WG7-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: A5ED46A402EEB3DC	FASTA	322	38,099
	10 20 30 40 50 60 MRLFVLLAYI IPFILCQLTP VLVASHKLVR GLKEEINPSN TLPHNVTSVT NMLKKLITEC 70 80 90 100 110 120 SSDAYLLINQ PGLTYADLTT EKKDNWPFLR NYLYMSSTIV GLPRVENPID LDFLEQYIIS 130 140 150 160 170 180 NCDAETINVW HDSEDEVVDY YDIRKRVIRI DLSPLSISNH DDRVKEIFEH DQLIRKILRK 190 200 210 220 230 240 LPSAHYTIIL TSLEPGIIHP VPRFLMEETP ASFEIFDDII NDPFHNREIE KNDRFHKVEP 250 260 270 280 290 300 NWNPIRDSND RYYRNKKKDE IHLFDYELWE KNEKLITTIF VMVLSLFMMK IISFFNYLKQ 310 320 KIIQKKQQKS KRGIIADDKK LD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.
[2]	"Deletion of the CaBIG1 gene reduces beta-1,6-glucan synthesis, filamentation, adhesion, and virulence in Candida albicans." Umeyama T., Kaneko A., Watanabe H., Hirai A., Uehara Y., Niimi M., Azuma M. Infect. Immun. 74:2373-2381(2006) [PubMed: 16552067] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, GLYCOSYLATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000114 Genomic DNA. Translation: EAK94840.1. AACQ01000113 Genomic DNA. Translation: EAK94899.1.
RefSeq	XP_713939.1. XP_713997.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3644388. 3644434.
KEGG	cal:CaO19.2334. cal:CaO19.9870.
Organism-specific databases
CGD	CAL0000722. BIG1.
Family and domain databases
InterPro	IPR013160. BIG1. [Graphical view]
Pfam	PF08319. BIG1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BIG1_CANAL

Accession

Primary (citable) accession number: Q59WG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	April 26, 2005
Last modified:	November 4, 2008
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)