Reviewed, UniProtKB/Swiss-Prot Q59Z51 (ATP23_CANAL)

Names and origin

Protein names

Recommended name:
    Mitochondrial inner membrane protease ATP23
    EC=3.4.24.-

Gene names

Name:	ATP23
ORF Names:	CaO19.2249, CaO19.9789

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Has a dual role in the assembly of mitochondrial ATPase. Acts as a protease that removes N-terminal residues of mitochondrial ATPase CF(0) subunit 6 at the intermembrane space side. Also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle, probably mediating association of subunit 6 with the subunit 9 ring By similarity.
Subcellular location	Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note= Associates loosely with the inner membrane By similarity.
Sequence similarities	Belongs to the peptidase M76 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Ligand	Metal-binding
Molecular function	Hydrolase Metalloprotease Protease
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metallopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 238	238	Mitochondrial inner membrane protease ATP23		PRO_0000330057
Sites
	Active site	139	1	By similarity
	Metal binding	138	1	Divalent metal cation; catalytic By similarity
	Metal binding	142	1	Divalent metal cation; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q59Z51-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 2B6F30383496070D	FASTA	238	27,808
	10 20 30 40 50 60 MSTAAPQENS PELKLSPSSK LNGFEWWRRT LSYQTGLGLN AEEKAQYEFD YNNRNLAEKC 70 80 90 100 110 120 QQCNEYRNWM LEYSPSVLFM MDHIKKLTKD KEPILTKENI TCDVCDFTKG GGFHPDEGIL 130 140 150 160 170 180 LCANWIRNKW QLEDILTHEL VHVYDYLKFD LDMNNLRHHA CTEIRASMLS GECRIWQEIK 190 200 210 220 230 KTGLGNFGKK FQDCIKRRAV LSVSSNPICK SPEEAEKVVS TVWNSCFNDT RPFERVYR

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000096 Genomic DNA. Translation: EAK95734.1. AACQ01000095 Genomic DNA. Translation: EAK95798.1.
RefSeq	XP_714777.1. XP_714839.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3643527. 3643576.
KEGG	cal:CaO19.2249. cal:CaO19.9789.
Organism-specific databases
CGD	CAL0006273. orf19.2249.
Family and domain databases
InterPro	IPR006025. Pept_M_Zn_BS. [Graphical view]
PROSITE	PS00142. ZINC_PROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATP23_CANAL

Accession

Primary (citable) accession number: Q59Z51

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	April 26, 2005
Last modified:	November 25, 2008
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)