Reviewed, UniProtKB/Swiss-Prot Q59ZB1 (ADA_CANAL)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:	AAH1
ORF Names:	CaO19.2251, CaO19.9791

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H(2)O = inosine + NH(3).
Subcellular location	CytoplasmBy similarity. NucleusBy similarity.
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Cellular component	Cytoplasm Nucleus
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 356	356	Adenosine deaminase		PRO_0000256232
Sites
	Active site	211	1	Potential
	Active site	259	1	Potential
	Active site	292	1	Potential
	Active site	293	1	Potential
Natural variations
	Natural variant	273	1	K → T in allele CaO19.9791.
	Natural variant	284	1	N → T in allele CaO19.9791.

Sequences

	Sequence		Length	Mass (Da)
	Q59ZB1-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: B22B1ED9D27A9F19	FASTA	356	40,782
	10 20 30 40 50 60 MAQYECSEHM ENFLRELPKC EHHVHLEGTL EPSLLFKLAK RNNITLPETF PKTVEECNDR 70 80 90 100 110 120 YNRFADLQDF LDHYYIGMGV LITENDFYDL AMDYFTKAHS DGCLHSEVFF DPQGHVERNI 130 140 150 160 170 180 DIDVVVQGFN RACKDANTKY GTTNKLIMCL LRHLPAENGL QTIHSASKYY QDGIIHGLGL 190 200 210 220 230 240 DSSEKPFPPN LFTECYAHIK DNFPEVGLTA HAGEEGDHTF VSDALNLLKV SRIDHGVNSH 250 260 270 280 290 300 QSEELMQRLA EQKTLLSLCP LSNVKLQVVK DVKELPIDKF FQMNVPFSIN SDDPAYFGGY 310 320 330 340 350 ILDNYKAVHT RFGFTKDQWK IIALNGIKGS WCDDQRKNEL ISLVEEVYKK YNIEGC

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000095 Genomic DNA. Translation: EAK95800.1. AACQ01000096 Genomic DNA. Translation: EAK95736.1.
RefSeq	XP_714779.1. XP_714841.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3643529. 3643578.
KEGG	cal:CaO19.2251. cal:CaO19.9791.
Organism-specific databases
CGD	CAL0006286. AAH1.
Family and domain databases
InterPro	IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADA_CANAL

Accession

Primary (citable) accession number: Q59ZB1
Secondary accession number(s): Q59Z49

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	April 26, 2005
Last modified:	November 25, 2008
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)