Reviewed, UniProtKB/Swiss-Prot Q5A5N6 (ALG14_CANAL)

Names and origin

Protein names

Recommended name:
    UDP-N-acetylglucosamine transferase subunit ALG14
Alternative name(s):
    Asparagine-linked glycosylation protein 14

Gene names

Name:	ALG14
ORF Names:	CaO19.5363, CaO19.12823

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER By similarity.
Subunit structure	Heterodimer with ALG13 to form a functional enzyme By similarity.
Subcellular location	Endoplasmic reticulum membrane; Single-pass membrane proteinBy similarity.
Sequence similarities	Belongs to the ALG14 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane
Gene Ontology (GO)
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 219	219	UDP-N-acetylglucosamine transferase subunit ALG14		PRO_0000123811
Regions
	Topological domain	1 – 8	8	Lumenal Potential
	Transmembrane	9 – 29	21	Potential
	Topological domain	30 – 219	190	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5A5N6-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: AED3C21A782E7C41	FASTA	219	24,460
	10 20 30 40 50 60 MDIETAACFS IAFIATPILI VLVRLLFILP SLRLPTSVKK KKKLIQECQL SILLGSGGHT 70 80 90 100 110 120 GEMMRIISKL DMGKVSRTWI YTSGDNASLA KAQDYERKSG TSSQYIPIPR ARTVGQSYIS 130 140 150 160 170 180 SIPTTIYSFL FSAIAMLKHR PAVILLNGPG TCVPVAYILF LYKLLGLCNT KIIYIESLAR 190 200 210 VNKLSLSGLL LLPISDRFIV QWESLYQQYS RVEYYGILI

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000059 Genomic DNA. Translation: EAK98110.1. AACQ01000058 Genomic DNA. Translation: EAK98191.1.
RefSeq	XP_717086.1. XP_717165.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3641242. 3641295.
KEGG	cal:CaO19.12823. cal:CaO19.5363.
Organism-specific databases
CGD	CAL0004350. orf19.5363.
Family and domain databases
InterPro	IPR013969. Oligosacch_biosynth_Alg14. [Graphical view]
PANTHER	PTHR12154. Oligosacch_biosynth_Alg14. 1 hit.
Pfam	PF08660. Alg14. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALG14_CANAL

Accession

Primary (citable) accession number: Q5A5N6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	April 26, 2005
Last modified:	November 4, 2008
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)