Reviewed, UniProtKB/Swiss-Prot Q5A649 (ATG1_CANAL)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase ATG1
    EC=2.7.11.1
Alternative name(s):
    Autophagy-related protein 1

Gene names

Name:	ATG1
ORF Names:	CaO19.3841, CaO19.11322

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	834 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serine/threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 834	834	Serine/threonine-protein kinase ATG1		PRO_0000085641
Regions
	Domain	58 – 354	297	Protein kinase
	Nucleotide binding	64 – 72	9	ATP By similarity
Sites
	Active site	204	1	Proton acceptor By similarity
	Binding site	87	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5A649-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 4AF2BC2600AE652B	FASTA	834	92,963
	10 20 30 40 50 60 MIPQSNPTAQ RRSGDAQNTN NVAPNSVATT TDTALTASTQ SGSSSNNANK KLEYIGVYKI 70 80 90 100 110 120 GPEIGKGSFA TVYKCIDTTN NKAVAIKSVY RSKLKSKKLL ENLEIEIQIL KSMKHPHIVG 130 140 150 160 170 180 LLDYKQTTSY FHLVMDYCSM GDLSYFIRRR NNLVKSHPVI SSLLHRYPSP EGSHGLNEVL 190 200 210 220 230 240 VLHFLRQLSS ALQFLRDKSL VHRDIKPQNL LLCPPVHSKQ EFIDGEFVGM WELPILKIAD 250 260 270 280 290 300 FGFARFLPST SMAETLCGSP LYMAPEILRY EKYNAKADLW SVGAVLYEMT VGKPPFKAGN 310 320 330 340 350 360 HIELLKNIEK ANDKIKFPSA AQVPEPLKQL IRSLLKYNPT ERISFNEFFN DSLITCDLDD 370 380 390 400 410 420 NDQPLETSQM DENLFISEYI SPIAPAERSQ FFKEQKKNDS VVRSPSPTTA TTATPRQDNV 430 440 450 460 470 480 VQQMTKITSP VPDDFALSIA RNSSEFNLKK DDMNLEKDYV VVEKRAVEVN ALADELAHAG 490 500 510 520 530 540 AGADAIPNSR KNSDVDQTNR LASSQQQTET ASYRRSSSSG SQKRPSFSER RISLSLSPTN 550 560 570 580 590 600 ALTKAIGLAS NRLFGLTTNS SHSNVSAIAE DDDSSTSNND ASSFSTVIPS TNNHVLLQKL 610 620 630 640 650 660 NLATIGEPGT EFDLGSVSNL DEQILDKLEL IANIANAVNL YADVKFSQII PSPPSSDGIE 670 680 690 700 710 720 DDTEMLPPKI IHMISQEGIG LYIKTLSLLG RAMDIAGQWW FEKYDAVHGE RPSFETTVRI 730 740 750 760 770 780 NQIVQWIREK YNISLERLEF LKSKSDFTAE ETIEDNEPNG TTRVQQAIFA AALGIARETA 790 800 810 820 830 LKELLRNSTD IECSYVTSIY MLLAILEDLE ESDRQEVKKI IEKINSRLKN FMGK

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000057 Genomic DNA. Translation: EAK98272.1. AACQ01000056 Genomic DNA. Translation: EAK98349.1.
RefSeq	XP_717245.1. XP_717321.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3641066. 3641175.
KEGG	cal:CaO19.11322. cal:CaO19.3841.
Organism-specific databases
CGD	CAL0002062. orf19.3841.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG1_CANAL

Accession

Primary (citable) accession number: Q5A649

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	April 26, 2005
Last modified:	November 25, 2008
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)