Reviewed, UniProtKB/Swiss-Prot Q5A950 (ATG26_CANAL)

Names and origin

Protein names

Recommended name:
    Sterol 3-beta-glucosyltransferase
    EC=2.4.1.173
Alternative name(s):
    Autophagy-related protein 26
    UDP-glycosyltransferase 51

Gene names

Name:	ATG26
Synonyms:	UGT51, UGT51C, UGT51C1
ORF Names:	CaO19.2616, CaO19.10147

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	1513 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	May be involved in decane metabolism and autophagy By similarity. Involved in the biosynthesis of sterol glucoside.
Catalytic activity	UDP-glucose + a sterol = UDP + a sterol 3-beta-D-glucoside.
Subcellular location	CytoplasmBy similarity. Membrane; Peripheral membrane proteinBy similarity.
Sequence similarities	Belongs to the glycosyltransferase 28 family. Contains 2 GRAM domains. Contains 1 PH domain.

Ontologies

Keywords
Biological process	Autophagy Lipid synthesis Protein transport Steroid biosynthesis Sterol biosynthesis Transport
Cellular component	Cytoplasm Membrane
Domain	Repeat
Molecular function	Glycosyltransferase Transferase
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro lipid glycosylation Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW sterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	sterol 3-beta-glucosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1513	1513	Sterol 3-beta-glucosyltransferase		PRO_0000215607
Regions
	Domain	296 – 331	36	GRAM 1
	Domain	359 – 520	162	PH
	Domain	816 – 880	65	GRAM 2
	Compositional bias	57 – 62	6	Poly-Asp
	Compositional bias	190 – 234	45	Thr-rich
	Compositional bias	1466 – 1485	20	Asp-rich
	Compositional bias	1486 – 1492	7	Poly-Glu
Natural variations
	Natural variant	164	1	E → K in allele CaO19.10147.
	Natural variant	203	1	K → R in allele CaO19.10147.
	Natural variant	206	1	T → TAT in allele CaO19.10147.
	Natural variant	235	1	E → K in allele CaO19.10147.
Experimental info
	Sequence conflict	561	1	V → A in AAD29571. Ref.1
	Sequence conflict	625	1	S → L in AAD29571. Ref.1
	Sequence conflict	810	1	D → E in AAD29571. Ref.1
	Sequence conflict	1130	1	A → G in AAD29571. Ref.1
	Sequence conflict	1290	1	K → R in AAD29571. Ref.1
	Sequence conflict	1492	1	E → EE in AAD29571. Ref.1
	Sequence conflict	1507	1	P → R in AAD29571. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q5A950-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: DEE886A8BF9319FA	FASTA	1,513	170,545
	10 20 30 40 50 60 MSFYKKVTRG LATPLQGSIN LFSGSPNVSG DEGTDADNEN PEHRTTYHSL SGRVNHDDDD 70 80 90 100 110 120 EDVAKLEDIV GFFTGLLNTT TVCAGLGSLN NLKKHYLDEF IKKSALNPLR PQNYGPETSS 130 140 150 160 170 180 KLNNNSIEEL LNNGDTSLEK VRKMSLYDFD EHTSDSEEED SADEEEESIA ENLKPGKSGK 190 200 210 220 230 240 ARNHPRDSRT TATLITTQIT RTKTATTATP TPTPTSSVDT DVTDVTEPIG KVTTEIPEEQ 250 260 270 280 290 300 LQGLNPLQKS VVKNLDPHHV REGVLIKVKN SETPLKNDRQ ELLEKIQLRL KIADKLQRVF 310 320 330 340 350 360 DLSDEDTFCG NYSAWLIKDV LLQGHVYLTK DALLYFAFLP KRFSLENSSE VLDEDNSSSI 370 380 390 400 410 420 VYSGNLGLKS AKYGEVVLNT VLQHRYWAVL RAETLSIYSS STNLYFPVLV IDIKKCLYTE 430 440 450 460 470 480 IIDKEKLNRE AISPVNRGTY SPNGGLSGTA TPRASTLENT ASELNSMLSG DSYSPTEDNV 490 500 510 520 530 540 ETTASTVWFK LVTKKKTYKF SCDSSFSARQ WCNNITKLIF QHNNANSNGE VLIKIPISKI 550 560 570 580 590 600 AEYNKRALFS EEEEEDRTLD VTMNDIPLNV TIKYLGDNDN ERKRDKLKRK YKGEEPTIEE 610 620 630 640 650 660 VHFLFPKSGV EFFETFDKLV NPVVSDNDNQ SSKSSITSTN FSEKAISTLS KSPNHLVQTV 670 680 690 700 710 720 LDFNKPVDDD ISAFKKFGTT ITSPTRIFKA TITSPEMTSI DETSLRDSFD SDRLHLPRDM 730 740 750 760 770 780 SERALKNLEV SFVTSLKKLE DASKRYEKPH MEHSQTNLAS ILSDPSEVKK ESKTAISKSI 790 800 810 820 830 840 KALYSVGTHW SATPNHYFEL GKYYVNKVQD RDSSQRNFQS HFSTNSKLLA SYYGHLLRTV 850 860 870 880 890 900 PVYGKIYVSE TDVCFRSLLP GVSTKMVLPM TDIEEVRASR GSRLTYHGLR LIVRGSEELD 910 920 930 940 950 960 LEFGSSKSRD DFQKVVLSVL ERLHSKEGFR PEPYQWGSNF EVELYKTRME YSDSENREIQ 970 980 990 1000 1010 1020 QYDNSIDIKF AEKKIEMARV RMFEDRLMAA SGLDVPIILE DSPFFKTELR PSTSYNITLL 1030 1040 1050 1060 1070 1080 TIGSRGDVQP YIALGKGLVK EGHNVTIATH AEFGDWIKTF GLGFKEIAGD PAELMSFMVT 1090 1100 1110 1120 1130 1140 HNSMSVGFLK NAQQKFRSWI SKLLTTSWEA CQGSDILIES PSAMSGIHIA EALGIPYFRA 1150 1160 1170 1180 1190 1200 FTMPWTRTRA YPHAFFVPEQ KKGGSYNYLT HVLFENIFWK GISGQVNKWR VEELDLPKTN 1210 1220 1230 1240 1250 1260 LYRLQQTRVP FLYNVSPAIL PPSVDFPDWI KVTGYWFLDE GSGDYKPPEE LVQFMKKASR 1270 1280 1290 1300 1310 1320 DKKKIVYIGF GSIVVKDAKS LTKAVVSAVK RADVRCILNK GWSDRLDNKD KNEIEIELPP 1330 1340 1350 1360 1370 1380 EIYNSGTIPH DWLFPRIDAA VHHGGSGTTG ATMRAGIPTI IKPFFGDQFF YATRIEDLGA 1390 1400 1410 1420 1430 1440 GIALKKLTAK TLGDALVKAT HDLKIIDKAK RVSQQIKHEH GVLSAIESIY SELEYSRNLI 1450 1460 1470 1480 1490 1500 LIKDIHNQNY KRHHPVPSGV QTPAYDTDSD DYDDDEDDDE SDKDDEEEEE EENSYDGYDG 1510 NGVNNSPSQN SSN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and functional expression of UGT genes encoding sterol glucosyltransferases from Saccharomyces cerevisiae, Candida albicans, Pichia pastoris, and Dictyostelium discoideum." Warnecke D.C., Erdmann R., Fahl A., Hube B., Mueller F., Zank T., Zaehringer U., Heinz E. J. Biol. Chem. 274:13048-13059(1999) [PubMed: 10224056] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 1161.
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF091398 Genomic DNA. Translation: AAD29571.1. AACQ01000044 Genomic DNA. Translation: EAK99352.1. AACQ01000043 Genomic DNA. Translation: EAK99450.1.
RefSeq	XP_718281.1. XP_718376.1.
3D structure databases
HSSP	HSSP built from PDB template 1IIR based on UniProtKB P96559.
ModBase	Search...
Genome annotation databases
GeneID	3640058. 3640147.
KEGG	cal:CaO19.10147. cal:CaO19.2616.
Organism-specific databases
CGD	CAL0003385. UGT51C1.
Family and domain databases
InterPro	IPR004276. Glyco_trans_28. IPR004182. GRAM. IPR001849. PH. IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF03033. Glyco_transf_28. 1 hit. PF02893. GRAM. 1 hit. PF00169. PH. 1 hit. [Graphical view]
SMART	SM00568. GRAM. 2 hits. SM00233. PH. 1 hit. [Graphical view]
PROSITE	PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG26_CANAL

Accession

Primary (citable) accession number: Q5A950
Secondary accession number(s): Q5A9F2, Q9Y752

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	April 26, 2005
Last modified:	November 25, 2008
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)