Reviewed, UniProtKB/Swiss-Prot Q5ABA6 (ATG18_CANAL)

Names and origin

Protein names

Recommended name:
    Autophagy-related protein 18

Gene names

Name:	ATG18
ORF Names:	CaO19.6064, CaO19.13485

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	558 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and autophagy By similarity.
Subcellular location	Preautophagosomal structure membrane; Peripheral membrane proteinBy similarity. Vacuole membrane; Peripheral membrane proteinBy similarity. Note= Peripheral membrane protein of pre-autophagosomal structure (PAS) and vacuole By similarity.
Sequence similarities	Belongs to the WD repeat SVP1 family. Contains 2 WD repeats.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Membrane Vacuole
Domain	Repeat WD repeat
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	pre-autophagosomal structure membrane Inferred from electronic annotation. Source: UniProtKB-SubCell vacuolar membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 558	558	Autophagy-related protein 18		PRO_0000050862
Regions
	Repeat	247 – 287	41	WD 1
	Repeat	292 – 331	40	WD 2
	Compositional bias	370 – 389	20	Asp-rich

Sequences

	Sequence		Length	Mass (Da)
	Q5ABA6-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: F9293CAFEBAC473C	FASTA	558	61,660
	10 20 30 40 50 60 MLQTSSSSAT ASLQQQLSKQ YANSFSNDGS SFSSKNNQQY SEIVNYISFN QDASCITIGL 70 80 90 100 110 120 KNGYKIFNCQ PNFGRSFQFK NDESTGIVEM LYCTSLLATV AQGEEIGSSP RKLKIINTKT 130 140 150 160 170 180 KSTICDLIFP STILQVKLTN TRLIVVLEDQ IYLYDITTMK LLHTIETSPN LSGLSAISYD 190 200 210 220 230 240 DSNSYLAYPS PPKTITHDSL LASGINTNGG SNSTQNNISS VSNTPNRVGD VIIFNLTSLQ 250 260 270 280 290 300 PISVIEAHKS TIASMAFSNN GLYLATASDK GTIVRIFEVA TGTKLYQFRR GTYPTKIYSL 310 320 330 340 350 360 RFSADDKYVL ATSSSLTVHI FRLGEEEALE TKHKKKKIPA VATILEEETE GSQSNEQTKS 370 380 390 400 410 420 IKRNSEEFED IRDDGDDSDV DDEDGDIDDE SLEVIPAKQR KLSQGSTNSY TSVNSEDVQS 430 440 450 460 470 480 NSPKTEPLID QNRLSMARII RRSSQTLGRK AAQKMGDFLP SRFSSILEPT RNFASLKINA 490 500 510 520 530 540 HSKDTKSVAV MNNVLQQDLI PQTYLASDNA SAKQDLMEVS LFHIYVVTTE GMLYTYGLDP 550 ERGGDCILLN SHCILDEY

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000035 Genomic DNA. Translation: EAL00125.1. AACQ01000036 Genomic DNA. Translation: EAL00020.1.
RefSeq	XP_718924.1. XP_719026.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3639285. 3639421.
KEGG	cal:CaO19.13485. cal:CaO19.6064.
Organism-specific databases
CGD	CAL0005165. orf19.6064.
Family and domain databases
InterPro	IPR015943. WD40/YVTN_repeat-like. IPR001680. WD40_repeat. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF00400. WD40. 1 hit. [Graphical view]
SMART	SM00320. WD40. 2 hits. [Graphical view]
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. False negative. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG18_CANAL

Accession

Primary (citable) accession number: Q5ABA6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	April 26, 2005
Last modified:	November 4, 2008
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)