Reviewed, UniProtKB/Swiss-Prot Q5AC48 (ARP4_CANAL)

Names and origin

Protein names

Recommended name:
    Actin-related protein 4
Alternative name(s):
    Actin-like protein ARP4
      Short name=Actin-like protein 4

Gene names

Name:	ARP4
ORF Names:	CaO19.5623, CaO19.13069

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	469 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair By similarity.
Subunit structure	Component of the NuA4 histone acetyltransferase complex, of the INO80 chromatin remodeling complex, and of the SWR1 chromatin remodeling complex By similarity.
Subcellular location	NucleusBy similarity.
Sequence similarities	Belongs to the actin family. ARP4 subfamily.
Sequence caution	The sequence EAL00290.1 differs from that shown. Reason: Erroneous termination at position 144. Translated as Ser.

Ontologies

Keywords
Biological process	DNA damage DNA repair Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Activator Chromatin regulator
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 469	469	Actin-related protein 4		PRO_0000089093
Natural variations
	Natural variant	129	1	D → F in allele CaO19.13069.
	Natural variant	132	1	R → S in allele CaO19.13069.
	Natural variant	136	1	I → L in allele CaO19.13069.
	Natural variant	143	1	A → V in allele CaO19.13069.
	Natural variant	163	1	L → S in allele CaO19.13069.
	Natural variant	346	1	Missing in allele CaO19.13069.

Sequences

	Sequence		Length	Mass (Da)
	Q5AC48-1 [UniParc]. Last modified December 20, 2005. Version 2. Checksum: 9037E5140160993A	FASTA	469	52,808
	10 20 30 40 50 60 MATASTTTVY GGDEINAIVL DPGSYTTRIG YAGDDFPKVI TSSYYGQVKN DKKKIFGESI 70 80 90 100 110 120 NVPRANYDIK PILKESIIVD WDAAIEQYQY YFDQQLKVVG PEQPILITEP IWTETSYRQQ 130 140 150 160 170 180 LVETFFENDE FRGIYIAKSP TCASFQQGRS NCLVVDLGHD SVLVTPVIDG ICLLKSSMKT 190 200 210 220 230 240 NYGGKFLSNE IQDYLIDTKK VVMEPSFKIK SKIPTTYPDP PKYELKNNNT IPTSSSSSLS 250 260 270 280 290 300 QSFLEFQNEK IYHNFKEILE VPEKNSSSGT TTTTTTTNKD SSRLFELPTG QSIVIDRFKI 310 320 330 340 350 360 AESIFDPTIY KFTNSKLSFP PNNGEISITQ ANEYRPLKRV RKNDDDEEED SNQSTPKPEV 370 380 390 400 410 420 NIRGISQLIS HTLSNIDIDL RASLANNIIV TGGVSLISQL TERLYLELSN NNPGLKIRLH 430 440 450 460 AVGNSTERIN QAWIGGSVLA SLGTFHQMWV TKEEYNEVGV DRILNQRFR

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000034 Genomic DNA. Translation: EAL00290.1. Sequence problems. AACQ01000033 Genomic DNA. Translation: EAL00412.1.
RefSeq	XP_719183.1. XP_719300.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3639131. 3639201.
KEGG	cal:CaO19.13069. cal:CaO19.5623.
Family and domain databases
InterPro	IPR004001. Actin_CS. IPR004000. Actin_like. [Graphical view]
PANTHER	PTHR11937. Actin_like. 1 hit.
Pfam	PF00022. Actin. 1 hit. [Graphical view]
SMART	SM00268. ACTIN. 1 hit. [Graphical view]
PROSITE	PS00406. ACTINS_1. False negative. PS00432. ACTINS_2. 1 hit. PS01132. ACTINS_ACT_LIKE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARP4_CANAL

Accession

Primary (citable) accession number: Q5AC48
Secondary accession number(s): Q5ABS7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	December 20, 2005
Last modified:	November 25, 2008
This is version 29 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)