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Reviewed, UniProtKB/Swiss-Prot Q5ADX5 (MCES_CANAL)

Last modified November 25, 2008. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    mRNA cap guanine-N7 methyltransferase
    EC=2.1.1.56
Alternative name(s):
    mRNA (guanine-N(7)-)-methyltransferase
    mRNA cap methyltransferase
Gene names
Name: ABD1
Synonyms: CCM1
ORF Names: CaO19.6716, CaO19.14008
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

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Protein attributes

Sequence length474 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Responsible for methylating the 5'-cap structure of mRNAs. Ref.1

Catalytic activity

S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5')pppR-RNA.

Subcellular location

NucleusBy similarity.

Sequence similarities

Belongs to the mRNA cap methyltransferase family.

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Ontologies

Keywords

   Biological processmRNA capping
mRNA processing
   Cellular componentNucleus
   LigandRNA-binding
S-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase

Gene Ontology (GO)

   Biological processmRNA capping

Inferred from electronic annotation. Source: InterPro

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

mRNA (guanine-N7-)-methyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 474474mRNA cap guanine-N7 methyltransferase
PRO_0000303905

Experimental info

Sequence conflict861V → A in BAA82446. Ref.2
Sequence conflict1331T → K in AAF69030. Ref.1
Sequence conflict2951I → V in BAA82446. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
Q5ADX5-1 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: EE195FE2695A1238

FASTA47454,248
        10         20         30         40         50         60 
MSTDSYTPSQ EPGSKRLKTG ESVFARRGVS PSTGGVASAY GNESEKKPSW LQTNKSDIDG 

        70         80         90        100        110        120 
KYDKYGERRN AHTTTRDSRL DRLKRVRQKS AEREDVGHEG DEGDEDEGIL PYIHLQAANP 

       130        140        150        160        170        180 
AIIHNEKQEN YRTFQSRISN RENRDINSIV RAHYNQRTQQ AKQQGSRVNS PIYKMRNFNN 

       190        200        210        220        230        240 
AIKYILLGNW AKHNPEELDL FSFLDLCCGK GGDLNKCQFI GIDQYIGIDI ADLSVKEAFE 

       250        260        270        280        290        300 
RYTKQKARFR HSNQNSNRYT FEACFATGDC FTQFVPDILE PNFPGIIERA FPVDIVSAQF 

       310        320        330        340        350        360 
SLHYSFESEE KVRTLLTNVT RSLRSGGTFI GTIPSSDFIK AKIVDKHLQR DEKGKAKFGN 

       370        380        390        400        410        420 
SLYSVTFEKD PPEDGVFRPA FGNKYNYWLK DAVDNVPEYV VPFETLRSLC EEYDLVLKYK 

       430        440        450        460        470 
KSFTDIFNQE IPKYFSKLNK NLIDGMKRSD GKYGAEGDEK EAVAFYIGFV FEKV

« Hide

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References

« Hide 'large scale' references
[1]"Characterization of human, Schizosaccharomyces pombe, and Candida albicans mRNA cap methyltransferases and complete replacement of the yeast capping apparatus by mammalian enzymes."
Saha N., Schwer B., Shuman S.
J. Biol. Chem. 274:16553-16562(1999) [PubMed: 10347220] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[2]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314.

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Cross-references

Sequence databases

AF133529 Genomic DNA. Translation: AAF69030.1.
AB020965 Genomic DNA. Translation: BAA82446.1.
AACQ01000029 Genomic DNA. Translation: EAL00823.1.
AACQ01000028 Genomic DNA. Translation: EAL00948.1.
RefSeqXP_719698.1.
XP_719815.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3638456.
3638594.
KEGGcal:CaO19.14008.
cal:CaO19.6716.

Organism-specific databases

CGDCAL0004754. ABD1.

Family and domain databases

InterProIPR016899. mRNA_G-N7_MeTrfase.
IPR004971. Pox_MCEL.
[Graphical view]
PfamPF03291. Pox_MCEL. 1 hit.
[Graphical view]
PIRSFPIRSF028762. ABD1. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameMCES_CANAL
AccessionPrimary (citable) accession number: Q5ADX5
Secondary accession number(s): Q9P936, Q9Y8H4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: April 26, 2005
Last modified: November 25, 2008
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

Candida albicans

Candida albicans: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents