Reviewed, UniProtKB/Swiss-Prot Q5AGC7 (BUD32_CANAL)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase BUD32
    EC=2.7.11.1

Gene names

Name:	BUD32
ORF Names:	CaO19.4252, CaO19.11727

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Component of the EKC/KEOPS complex which promotes both telomere uncapping and telomere elongation By similarity. The complex is required for efficient recruitment of transcriptional coactivators. Important for bud site selection By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Component of the EKC/KEOPS complex By similarity.
Subcellular location	CytoplasmBy similarity. NucleusBy similarity. TelomereBy similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Chromosomal protein Cytoplasm Nucleus Telomere
Ligand	ATP-binding Nucleotide-binding
Molecular function	Activator Kinase Serine/threonine-protein kinase Transferase
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chromosome, telomeric region Inferred from electronic annotation. Source: UniProtKB-KW cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 296	296	Serine/threonine-protein kinase BUD32		PRO_0000278908
Regions
	Domain	15 – 296	282	Protein kinase
	Nucleotide binding	21 – 29	9	ATP By similarity
Sites
	Active site	177	1	Proton acceptor By similarity
	Binding site	61	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5AGC7-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 81C9B27FA2A873B7	FASTA	296	33,882
	10 20 30 40 50 60 MTDHLIAKVQ EHVPNIPLKI ISQGAEALVF ETSVHPYYNY NSSEKHHESP SLHNHTTFII 70 80 90 100 110 120 KYRPTKPYRH PKIDLQINKS RTIGEVKFMY KLSKLNIACP NIISTDFNNG IIWMECLGSK 130 140 150 160 170 180 LPNGTISSFK NWLWYLESQE KEDPSINLHD DDQVELVCQK VGQLIGRLHL NDMIHGDLTS 190 200 210 220 230 240 SNIILTEVDT KKNEDTDANN SSVYFEPALI DFGLSSFSGL AEDKAVDLYV LERAILSTHS 250 260 270 280 290 NYADKLNGWL LEGYQQIHDS IEFNKTKQQL GKSKLKDTIK RLEDVRLRGR KRSMLG

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000021 Genomic DNA. Translation: EAL01857.1. AACQ01000022 Genomic DNA. Translation: EAL01724.1.
RefSeq	XP_720561.1. XP_720688.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3637607. 3637728.
KEGG	cal:CaO19.11727. cal:CaO19.4252.
Organism-specific databases
CGD	CAL0000253. orf19.4252.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR008266. Tyr_pkinase_AS. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BUD32_CANAL

Accession

Primary (citable) accession number: Q5AGC7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 6, 2007
Last sequence update:	April 26, 2005
Last modified:	November 25, 2008
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)