Reviewed, UniProtKB/Swiss-Prot Q5AI22 (ATG21_CANAL)

Names and origin

Protein names

Recommended name:
    Autophagy-related protein 21

Gene names

Name:	ATG21
ORF Names:	CaO19.3030, CaO19.10548

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	529 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Required for cytoplasm to vacuole transport (Cvt) vesicles formation and autophagy By similarity.
Subcellular location	CytoplasmBy similarity. Membrane; Peripheral membrane proteinBy similarity. Vacuole membrane; Peripheral membrane proteinBy similarity. Note= Vacuolar and perivacuolar punctate structures By similarity.
Sequence similarities	Belongs to the WD repeat SVP1 family. Contains 2 WD repeats.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm Membrane Vacuole
Domain	Repeat WD repeat
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	vacuolar membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 529	529	Autophagy-related protein 21		PRO_0000050876
Regions
	Repeat	271 – 311	41	WD 1
	Repeat	321 – 361	41	WD 2

Sequences

	Sequence		Length	Mass (Da)
	Q5AI22-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: A31F3C9C491028EB	FASTA	529	60,019
	10 20 30 40 50 60 MVTINDLSFN PDYSSISVST SDGFKIFNCE PFGEFYSSQE SPLRKSISNS LEDSAGCQNP 70 80 90 100 110 120 THSKTDSQDT PARFPTAFLK MLFSTSLTIV VPQTQDNLGN RLLKIYNLKQ NLKICELNFP 130 140 150 160 170 180 SSIIDIKLNR KRLLVVLDTG QLYIYDLSCV RLLKILQLSF NEHDGDQKFI GDLSADDSSW 190 200 210 220 230 240 LIIPVQSTNN QTDLLNAETG SQPSTPKLTP SDSVINTGSY SQYLEFTRNS SLSNLKKKNK 250 260 270 280 290 300 LITLEDIKND SEGWVVVYDT INLAPVVIFE AHHSTIARIC ISHRDNKVAT ASIKGTIIRI 310 320 330 340 350 360 FDLKEFEGKV KVHKVKNLRR GHNLVKVNSL SFHNDNHILG CGSESNTIHL FKIHEEESDI 370 380 390 400 410 420 CTNENSEDRT NHNSDYEDSD GDTSKSSEDL NENLANLLIS KPLDPVPMET EDKLSSSWFV 430 440 450 460 470 480 KTKKLINNQY TSSIIKKLPY KDYFENLIWE PPQRSFAYIK LPEYAPHNEK DPRSNKVEIG 490 500 510 520 FNNDLVFIAS YHTGNFYQYQ IPKQRGPVSS INEDDKREEC SLISQFNLI

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000015 Genomic DNA. Translation: EAL02730.1. AACQ01000017 Genomic DNA. Translation: EAL02450.1.
RefSeq	XP_721257.1. XP_721528.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3636859. 3637123.
KEGG	cal:CaO19.10548. cal:CaO19.3030.
Organism-specific databases
CGD	CAL0001380. orf19.3030.
Family and domain databases
InterPro	IPR015943. WD40/YVTN_repeat-like. IPR001680. WD40_repeat. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF00400. WD40. 1 hit. [Graphical view]
SMART	SM00320. WD40. 2 hits. [Graphical view]
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. False negative. PS50294. WD_REPEATS_REGION. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG21_CANAL

Accession

Primary (citable) accession number: Q5AI22

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	April 26, 2005
Last modified:	November 4, 2008
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)