Reviewed, UniProtKB/Swiss-Prot Q5AI37 (ARX1_CANAL)

Names and origin

Protein names

Recommended name:
    Probable metalloprotease ARX1
    EC=3.-.-.-
Alternative name(s):
    Associated with ribosomal export complex protein 1

Gene names

Name:	ARX1
ORF Names:	CaO19.3015, CaO19.10533

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	564 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Probable metalloprotease involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm By similarity.
Subunit structure	Component of the nucleoplasmic and cytoplasmic pre-60S ribosomal particles By similarity.
Subcellular location	CytoplasmBy similarity. NucleusBy similarity.
Sequence similarities	Belongs to the peptidase M24 family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Ligand	Metal-binding
Molecular function	Hydrolase Metalloprotease Protease
Gene Ontology (GO)
Biological process	cellular process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 564	564	Probable metalloprotease ARX1		PRO_0000148993

Sequences

	Sequence		Length	Mass (Da)
	Q5AI37-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 1B95FF8831F0CCA8	FASTA	564	62,233
	10 20 30 40 50 60 MQLAVRQEDA DILLKQKNVL DELVVEKYRV AGQITQTALA YITSLINNSY HLQTSPKLTI 70 80 90 100 110 120 QQLCLLTDSF LLKLLSRQYV NKVNEKGIAH PTTINVNQLL NGFSPEIDDE REFFLNQGDV 130 140 150 160 170 180 VTISLGVHID GYTSQVSHTL VIYPPSADAK PEGPLLGSNA DALCACHLAT ESVVVLLGCS 190 200 210 220 230 240 LSPEKLPANL KNVSNTVTGS QIRELVDAIA DSFNCVVVPG SKIRRVRRFL AGQAEGIVAE 250 260 270 280 290 300 RDFKGVVWDE SHQEARLLKQ SNNTSTDLIL SDSNKPVQTN NSSAIPTDDF VVVPGEVYQI 310 320 330 340 350 360 DIRMTGLSDV NEIGIVTTEE IDHFTGKNNK QDFNAKSSIF IRDFAVTHQL KLKTSKKLLG 370 380 390 400 410 420 EIDRQFSVYP FKLDYASKNF PINTESSEDE IKQQIAAIGQ DMKSNRLGAA ELSNRHLIQP 430 440 450 460 470 480 KPIQTTKFIP LKEILLSANP TGKHGIDATK PVLPGMEIPL PNLGVSSLKL KSLLKTGRSI 490 500 510 520 530 540 NNVRESTTVA INENNQELIR LTGGEATAKS NWVHSQYKLP ASLNETIGQL VQISKDKRFG 550 560 IKIKEVVPYK VQQSNMSVES MQID

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000015 Genomic DNA. Translation: EAL02715.1. AACQ01000017 Genomic DNA. Translation: EAL02435.1.
RefSeq	XP_721242.1. XP_721513.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3636811. 3637175.
KEGG	cal:CaO19.10533. cal:CaO19.3015.
Organism-specific databases
CGD	CAL0001348. orf19.3015.
Family and domain databases
InterPro	IPR000994. Peptidase_M24_cat_core. [Graphical view]
Gene3D	G3DSA:3.90.230.10. Peptidase_M24_cat_core. 1 hit.
PANTHER	PTHR10804. Peptidase_M24_cat_core. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARX1_CANAL

Accession

Primary (citable) accession number: Q5AI37

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	April 26, 2005
Last modified:	December 16, 2008
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)