Reviewed, UniProtKB/Swiss-Prot Q5AJC1 (BRO1_CANAL)

Names and origin

Protein names

Recommended name:
    Vacuolar protein-sorting protein BRO1
Alternative name(s):
    BRO domain-containing protein 1

Gene names

Name:	BRO1
ORF Names:	CaO19.1670, CaO19.9239

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	945 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles By similarity.
Subcellular location	CytoplasmBy similarity. EndosomeBy similarity.
Sequence similarities	Belongs to the BRO1 family. Contains 1 BRO1 domain.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm Endosome
Domain	Coiled coil
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endosome Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 945	945	Vacuolar protein-sorting protein BRO1		PRO_0000218861
Regions
	Domain	4 – 455	452	BRO1
	Coiled coil	606 – 643	38	Potential
	Compositional bias	244 – 274	31	Asp-rich
	Compositional bias	769 – 921	153	Gln-rich

Sequences

	Sequence		Length	Mass (Da)
	Q5AJC1-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: E6E3B6AAFB363319	FASTA	945	108,699
	10 20 30 40 50 60 MKTHLLVVPS KKTEEVNWVK PLNNYLLSIY GNTLQYQDDI NSLNKLRQDI RGVNADDTGL 70 80 90 100 110 120 KLYYSYYSKL ELIDLRIPFH DLNKSKKLQF EWFDSFSSLP YTQNSLAFEK ANVLYNIGAI 130 140 150 160 170 180 LSKFAQFKYN ESQQLNGPEG ETAFKQSISM LQQSSGIYQF INENFLHAPS QDLAQSTIKF 190 200 210 220 230 240 LSKLMMAQSQ EIFTLKVISG DLNQSKNSLI AKLCKSTSVL YEDCYNMINK NKKEGFKITN 250 260 270 280 290 300 ESYDGNDYED DLDDDDCDDL EGFLERPEDT EDSDNRYVAA ELDSSWISII YFKYEYYKSL 310 320 330 340 350 360 AYYFNGLHLD ANRKYGDAIA YLTKSQEVLN GVHSSTLKQV SKGSGDVYEL LDNYKYQKDA 370 380 390 400 410 420 VTIRLNDLNK DNDLIYHDIV PNLVTLPEIK PMDSTKIIKL GDNAMFHEIN EKNYNNFLVN 430 440 450 460 470 480 VVPVNIHELS SYYSEEKSQY LRNEIDHFEV SNEEVSSVLE YLKLPKALVS IKESLRGTSS 490 500 510 520 530 540 KGSTGNIDEL LSQSVIDKVN EISSQYSNDI QRKSTIENSR KEIYQLIKFL TENNCQDDAI 550 560 570 580 590 600 QLKKILYDAS VSDTKLFALV DETYHQTLGK GIQSTEFKSL FKTVDNKSSN QDSEISLLDI 610 620 630 640 650 660 IDDDDDDNTN QDKQIKNIED YLNDLNNIKQ AKFKLIEKLK KEIHNDDISD ILVLNMKLKS 670 680 690 700 710 720 TNEIKSIIFP EELKKFNPFT NELDKLITNE KSIIEQLKSR WNQLISNPQI KNLQTETNSK 730 740 750 760 770 780 NRLIISQSEK IDQFYGNWLK YHNGLIAGEK FYNQLLDQFK NFRNNIDNQL NQGMRSLNIG 790 800 810 820 830 840 QQFPTQPMLN RTQSSGLQSN YTGQSSISHS GSLSGQPSGG YNQPQPQQQQ LQQQQQQQQQ 850 860 870 880 890 900 AQFSGAYNQQ YSQPHGGYTQ FQGYGQGQGQ SQTGYQRQPP PPPPQLPPKQ SMGSYNFATT 910 920 930 940 LQQQQLPPQQ QQQPQQQRTP QNESNLIYDN PSTYNPNMYN FFSSK

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000014 Genomic DNA. Translation: EAL02832.1. AACQ01000013 Genomic DNA. Translation: EAL02959.1.
RefSeq	XP_721628.1. XP_721747.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3636590. 3636772.
KEGG	cal:CaO19.1670. cal:CaO19.9239.
Organism-specific databases
CGD	CAL0000103. BRO1.
Family and domain databases
InterPro	IPR004328. BRO1. [Graphical view]
Pfam	PF03097. BRO1. 1 hit. [Graphical view]
PROSITE	PS51180. BRO1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BRO1_CANAL

Accession

Primary (citable) accession number: Q5AJC1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	April 26, 2005
Last modified:	November 4, 2008
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)