Reviewed, UniProtKB/Swiss-Prot Q5ALX8 (APT_CANAL)

Names and origin

Protein names

Recommended name:
    Adenine phosphoribosyltransferase
      Short name=APRT
    EC=2.4.2.7

Gene names

Name:	APT1
ORF Names:	CaO19.1448, CaO19.9023

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity.
Catalytic activity	AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.
Cofactor	Magnesium By similarity.
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.
Subunit structure	Homodimer By similarity.
Subcellular location	CytoplasmBy similarity. NucleusBy similarity.
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
Biological process	Purine salvage
Cellular component	Cytoplasm Nucleus
Ligand	Magnesium Metal-binding
Molecular function	Glycosyltransferase Transferase
Gene Ontology (GO)
Biological process	adenine salvage Inferred from electronic annotation. Source: InterPro purine ribonucleoside salvage Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	adenine phosphoribosyltransferase activity Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 188	188	Adenine phosphoribosyltransferase		PRO_0000227899
Regions
	Nucleotide binding	134 – 138	5	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5ALX8-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 8CA335A0D1F675F6	FASTA	188	20,877
	10 20 30 40 50 60 MSDRVLEINA LAKELKANLK QFPNFPKEGI LFEDFLPIFT KPDLFNKLVK AFKLHVGEQK 70 80 90 100 110 120 IDYVIGLESR GFLFGPTLAL ALNAGFVPVR KPGKLPGPTF KVEFQKEYGS DEFEIQQDVI 130 140 150 160 170 180 PKGAKVLIVD DILATGGSAF GAGELAKKTG AEIVEYLFVM ELDFLKGRDK LDAPVYTLFG GQEEKFTE

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000008 Genomic DNA. Translation: EAL03604.1. AACQ01000007 Genomic DNA. Translation: EAL03751.1.
RefSeq	XP_722359.1. XP_722498.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3635842. 3635988.
KEGG	cal:CaO19.1448. cal:CaO19.9023.
Organism-specific databases
CGD	CAL0004599. APT1.
Family and domain databases
InterPro	IPR005764. Ade_phspho_trans. IPR002375. Pr/py_Pribosyl_transf_CS. IPR000836. PRibTrfase. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01090. apt. 1 hit.
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

APT_CANAL

Accession

Primary (citable) accession number: Q5ALX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	April 26, 2005
Last modified:	November 25, 2008
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)