Reviewed, UniProtKB/Swiss-Prot Q5BJE1 (CR034_HUMAN)

Names and origin

Protein names

Recommended name:
    Uncharacterized protein C18orf34

Gene names

Name:

C18orf34

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	867 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5BJE1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5BJE1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     607-644: Missing.

Notes: No experimental confirmation available.

Isoform 3 (identifier: Q5BJE1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     747-796: Missing.

Notes: No experimental confirmation availa38.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 867	867	Uncharacterized protein C18orf34		PRO_0000223316
Regions
	Coiled coil	153 – 204	52	Potential
	Coiled coil	233 – 414	182	Potential
	Coiled coil	445 – 470	26	Potential
	Coiled coil	662 – 696	35	Potential
Amino acid modifications
	Modified residue	50	1	Phosphotyrosine Ref.4
	Modified residue	53	1	Phosphoserine Ref.4
Natural variations
	Alternative sequence	607 – 644	38	Missing in isoform 2.		VSP_017257
	Alternative sequence	747 – 796	50	Missing in isoform 3.		VSP_017258
	Natural variant	42	1	A → T: dbSNP rs12606658.		VAR_047010
	Natural variant	465	1	V → E: dbSNP rs9965081. Ref.1		VAR_047011
	Natural variant	600	1	L → R: dbSNP rs457896.		VAR_047012
	Natural variant	601	1	D → N: dbSNP rs466113. Ref.1		VAR_047013
Experimental info
	Sequence conflict	49	1	L → I in BAC86407. Ref.1
	Sequence conflict	368	1	K → E in BAC86407. Ref.1
	Sequence conflict	768	1	I → F in BAC86407. Ref.1
	Sequence conflict	842 – 867	26	EESSN…CENDG → NQYDLEKE in AAH91517. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 14, 2008. Version 3. Checksum: 665719B544E55E9B	FASTA	867	102,011
	10 20 30 40 50 60 MTENKTVSSS STRDDQTNIG LTCQEVKALR EKAWSRTNEG NAMSQSLVLY GASKENSEGF 70 80 90 100 110 120 HESKMTNTEG VNKGIYFSYP CRRHSCAVVN IPAPCVNKMI SHIQDVESKI QEHLKRFETS 130 140 150 160 170 180 FEEWSRTSST KDLKEDWSVT TPVKEVKPGE KRDEKCPELK QEMETLLSEA IRLIKSLETD 190 200 210 220 230 240 RADAEEALKQ QRSRKNMINM KIDSWSVWKL QELPLAVQKE HEAYLSDVIE LQWHLEDKAN 250 260 270 280 290 300 QLQHFEKQKT ELEEANAKIQ ADIDYMNEHG PLLDSKQNQE LQDLKNHYKK KMEVMDLHRK 310 320 330 340 350 360 VNEELEEALE ACENARLKAQ QIKEEIDKDI YQDEKTIEAY KREIYQLNSL FDHYSSSVIN 370 380 390 400 410 420 VNTNIEEKEE EVTEAIRETK SSKNELHSLS KMLEDLRRVY DQLTWKQKSH ENQYLEAVND 430 440 450 460 470 480 FYAAKKTWDI ELSDVAKDFS AISLACTKLT EDNKKLEIDI NKITVKTNES IRKKSKYESE 490 500 510 520 530 540 IKYLTIMKLK NDKHLKNIYK EAYRIGTLFH LTKHKTDEME DKIAEVRRKF KGREEFLKKL 550 560 570 580 590 600 TQGEVAAGMV LQKKLYSIYE VQALERKELI KNRAICAMSL AELQEPLLQL EDEAERIRSL 610 620 630 640 650 660 DKEHSVMLNN IIDQKDLIRR KVGKVKKKLR KKGKKTLDAL IETESKRSAI FKDLEATKSK 670 680 690 700 710 720 TMIFYAKINE LNEELKAKEE EKKSFDQTLE ILKNKFITMR FKREHAQTVF DHYMQEKKDC 730 740 750 760 770 780 EERIFEEDQR FRVLLAVRQK TLQDTQKIIA DSLEENLRLA QEYQQLQITF LKEKDNYFNI 790 800 810 820 830 840 YDKQLSLDTS IRDKKQLCQL QRRMHTLWQE HFKLVVLFSQ MRLANFQTDS QESIQKILAV 850 860 QEESSNLMQH ILGFFQTLTD GTCENDG
	Isoform 2. Checksum: 74AAC4DA845C6B2C		829	97,566
	10 20 30 40 50 60 MTENKTVSSS STRDDQTNIG LTCQEVKALR EKAWSRTNEG NAMSQSLVLY GASKENSEGF 70 80 90 100 110 120 HESKMTNTEG VNKGIYFSYP CRRHSCAVVN IPAPCVNKMI SHIQDVESKI QEHLKRFETS 130 140 150 160 170 180 FEEWSRTSST KDLKEDWSVT TPVKEVKPGE KRDEKCPELK QEMETLLSEA IRLIKSLETD 190 200 210 220 230 240 RADAEEALKQ QRSRKNMINM KIDSWSVWKL QELPLAVQKE HEAYLSDVIE LQWHLEDKAN 250 260 270 280 290 300 QLQHFEKQKT ELEEANAKIQ ADIDYMNEHG PLLDSKQNQE LQDLKNHYKK KMEVMDLHRK 310 320 330 340 350 360 VNEELEEALE ACENARLKAQ QIKEEIDKDI YQDEKTIEAY KREIYQLNSL FDHYSSSVIN 370 380 390 400 410 420 VNTNIEEKEE EVTEAIRETK SSKNELHSLS KMLEDLRRVY DQLTWKQKSH ENQYLEAVND 430 440 450 460 470 480 FYAAKKTWDI ELSDVAKDFS AISLACTKLT EDNKKLEIDI NKITVKTNES IRKKSKYESE 490 500 510 520 530 540 IKYLTIMKLK NDKHLKNIYK EAYRIGTLFH LTKHKTDEME DKIAEVRRKF KGREEFLKKL 550 560 570 580 590 600 TQGEVAAGMV LQKKLYSIYE VQALERKELI KNRAICAMSL AELQEPLLQL EDEAERIRSL 610 620 630 640 650 660 DKEHSVSKRS AIFKDLEATK SKTMIFYAKI NELNEELKAK EEEKKSFDQT LEILKNKFIT 670 680 690 700 710 720 MRFKREHAQT VFDHYMQEKK DCEERIFEED QRFRVLLAVR QKTLQDTQKI IADSLEENLR 730 740 750 760 770 780 LAQEYQQLQI TFLKEKDNYF NIYDKQLSLD TSIRDKKQLC QLQRRMHTLW QEHFKLVVLF 790 800 810 820 SQMRLANFQT DSQESIQKIL AVQEESSNLM QHILGFFQTL TDGTCENDG
	Isoform 3. Checksum: 6E17C0996B9FAD6C		817	95,979
	10 20 30 40 50 60 MTENKTVSSS STRDDQTNIG LTCQEVKALR EKAWSRTNEG NAMSQSLVLY GASKENSEGF 70 80 90 100 110 120 HESKMTNTEG VNKGIYFSYP CRRHSCAVVN IPAPCVNKMI SHIQDVESKI QEHLKRFETS 130 140 150 160 170 180 FEEWSRTSST KDLKEDWSVT TPVKEVKPGE KRDEKCPELK QEMETLLSEA IRLIKSLETD 190 200 210 220 230 240 RADAEEALKQ QRSRKNMINM KIDSWSVWKL QELPLAVQKE HEAYLSDVIE LQWHLEDKAN 250 260 270 280 290 300 QLQHFEKQKT ELEEANAKIQ ADIDYMNEHG PLLDSKQNQE LQDLKNHYKK KMEVMDLHRK 310 320 330 340 350 360 VNEELEEALE ACENARLKAQ QIKEEIDKDI YQDEKTIEAY KREIYQLNSL FDHYSSSVIN 370 380 390 400 410 420 VNTNIEEKEE EVTEAIRETK SSKNELHSLS KMLEDLRRVY DQLTWKQKSH ENQYLEAVND 430 440 450 460 470 480 FYAAKKTWDI ELSDVAKDFS AISLACTKLT EDNKKLEIDI NKITVKTNES IRKKSKYESE 490 500 510 520 530 540 IKYLTIMKLK NDKHLKNIYK EAYRIGTLFH LTKHKTDEME DKIAEVRRKF KGREEFLKKL 550 560 570 580 590 600 TQGEVAAGMV LQKKLYSIYE VQALERKELI KNRAICAMSL AELQEPLLQL EDEAERIRSL 610 620 630 640 650 660 DKEHSVMLNN IIDQKDLIRR KVGKVKKKLR KKGKKTLDAL IETESKRSAI FKDLEATKSK 670 680 690 700 710 720 TMIFYAKINE LNEELKAKEE EKKSFDQTLE ILKNKFITMR FKREHAQTVF DHYMQEKKDC 730 740 750 760 770 780 EERIFEEDQR FRVLLAVRQK TLQDTQLCQL QRRMHTLWQE HFKLVVLFSQ MRLANFQTDS 790 800 810 QESIQKILAV QEESSNLMQH ILGFFQTLTD GTCENDG

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 454-867 (ISOFORM 3), VARIANTS GLU-465 AND ASN-601. Tissue: Kidney and Testis.
[2]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed: 16177791] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[4]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-50 AND SER-53, MASS SPECTROMETRY. Tissue: Epithelium.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK126038 mRNA. Translation: BAC86407.1. AK129955 mRNA. Translation: BAC85257.1. Different initiation. AC090371 Genomic DNA. No translation available. BC091517 mRNA. Translation: AAH91517.1.
RefSeq	NP_001098998.1. NP_945346.2.
UniGene	Hs.115461
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q5BJE1.
Genome annotation databases
Ensembl	ENSG00000166960. Homo sapiens. [Contig view]
GeneID	374864.
KEGG	hsa:374864.
Organism-specific databases
GeneCards	GC18M028771.
HGNC	HGNC:29588. C18orf34.
PharmGKB	PA134979792.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q5BJE1.
HOVERGEN	Q5BJE1.
Gene expression databases
ArrayExpress	Q5BJE1.
CleanEx	HS_C18orf34.
GermOnline	ENSG00000166960. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	100273.

Entry information

Entry name

CR034_HUMAN

Accession

Primary (citable) accession number: Q5BJE1
Secondary accession number(s): A6NDC6, Q6ZP67, Q6ZU20

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2006
Last sequence update:	October 14, 2008
Last modified:	December 16, 2008
This is version 28 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)