Reviewed, UniProtKB/Swiss-Prot Q5CZ79 (AN20B_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin repeat domain-containing protein 20B

Gene names

Name:

ANKRD20B

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	823 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 6 ANK repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	ANK repeat Coiled coil Repeat
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5CZ79-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5CZ79-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-428: Missing.
     429-439: FPKKLKEEHDK → MNFKINVFICR

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 823	823	Ankyrin repeat domain-containing protein 20B		PRO_0000328835
Regions
	Repeat	32 – 65	34	ANK 1
	Repeat	66 – 95	30	ANK 2
	Repeat	99 – 128	30	ANK 3
	Repeat	132 – 161	30	ANK 4
	Repeat	165 – 194	30	ANK 5
	Repeat	198 – 227	30	ANK 6
	Coiled coil	431 – 480	50	Potential
	Coiled coil	565 – 724	160	Potential
	Coiled coil	776 – 805	30	Potential
Natural variations
	Alternative sequence	1 – 428	428	Missing in isoform 2.		VSP_032809
	Alternative sequence	429 – 439	11	FPKKLKEEHDK → MNFKINVFICR in isoform 2.		VSP_032810
Experimental info
	Sequence conflict	618	1	G → C in CAI56787. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 8, 2008. Version 2. Checksum: 42F58A41BEB97330	FASTA	823	93,909
	10 20 30 40 50 60 MKLFGFGSRR GQTAEGSIDH VYTGSGYRIR DSELQKIHRA AVKGDAAEVE RCLARRSGDL 70 80 90 100 110 120 DARDKQHRTA LHLACASGHV QVVTLLVNRK CQIDICDKEN RTPLIQAVHC QEEACAVILL 130 140 150 160 170 180 KHGANPNLKD IYGNTALHYA VYSESTSLAE KLLSHGAHIE ALDKDSNTPL LFAIICKKEK 190 200 210 220 230 240 MVEFLLKKKA STHAVDRLRR SALMLAVYYD SPGIVSILLK QNIDVFAQDM CGRDAEDYAI 250 260 270 280 290 300 SHHLTKIQQQ ILEHKQKILK KEKSDVGSSD ESAVSIFHEL RVDSLPASDD KDLSVATKQC 310 320 330 340 350 360 VPEKVSEPLP GPSHEKGNRI VNGQGEGPPA KHPSLKPTTG VEDPAVKGAV QRKNVQTLRA 370 380 390 400 410 420 EQALPVASEE EQERHERSEK KQPQVKKGNN TNKSEKIQLS ENICDSTSSA AAGRLTQQRK 430 440 450 460 470 480 IGKTYPQQFP KKLKEEHDKC TLKQENEEKT NVNMLYKKNR EELERKEKQY KKEVEAKQLE 490 500 510 520 530 540 PTVQSLEMKS KTARNTPNRD FHNHEETKGL MDENCILKAD IAILRQEICT MKNDNLEKEN 550 560 570 580 590 600 KYLKDIKIVK ETNAALEKYI KLNEEMITET AFRYQQELND LKAENTRLNA ELLKEKESKK 610 620 630 640 650 660 RLEADIESYQ SRLAAAIGKH SESVKTERNV KLALERTQDV SVQVEMSSAI SKVKDENEFL 670 680 690 700 710 720 TEQLSETQIK FNALKDKFRK TRDSLRKKSL ALETVQNDLR KTQQQTQEMK EMYQNAEAKV 730 740 750 760 770 780 NNSTGKWNCV EERICHLQRE NAWLVQQLDD VHQKEDHKEI VTNIQRGFIE SGKKDLVLEE 790 800 810 820 KSKKLMNECD HLKESLFQYE REKAEGVVSI KEDKYFQTSR KKI
	Isoform 2. Checksum: C12C659053B3718D		395	46,654
	10 20 30 40 50 60 MNFKINVFIC RCTLKQENEE KTNVNMLYKK NREELERKEK QYKKEVEAKQ LEPTVQSLEM 70 80 90 100 110 120 KSKTARNTPN RDFHNHEETK GLMDENCILK ADIAILRQEI CTMKNDNLEK ENKYLKDIKI 130 140 150 160 170 180 VKETNAALEK YIKLNEEMIT ETAFRYQQEL NDLKAENTRL NAELLKEKES KKRLEADIES 190 200 210 220 230 240 YQSRLAAAIG KHSESVKTER NVKLALERTQ DVSVQVEMSS AISKVKDENE FLTEQLSETQ 250 260 270 280 290 300 IKFNALKDKF RKTRDSLRKK SLALETVQND LRKTQQQTQE MKEMYQNAEA KVNNSTGKWN 310 320 330 340 350 360 CVEERICHLQ RENAWLVQQL DDVHQKEDHK EIVTNIQRGF IESGKKDLVL EEKSKKLMNE 370 380 390 CDHLKESLFQ YEREKAEGVV SIKEDKYFQT SRKKI

References

[1]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

The German cDNA consortium Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC073464 Genomic DNA. No translation available. AC097374 Genomic DNA. No translation available. CR936649 mRNA. Translation: CAI56787.1. Different initiation.
UniGene	Hs.456852
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q5CZ79.
Proteomic databases
PRIDE	Q5CZ79.
Genome annotation databases
Ensembl	ENSG00000187984. Homo sapiens. [Contig view] ENSG00000204716. Homo sapiens. [Contig view]
Organism-specific databases
GeneCards	GC02M094791.
HGNC	HGNC:23666. ANKRD20B.
PharmGKB	PA134914536.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q5CZ79.
HOVERGEN	Q5CZ79.
Gene expression databases
ArrayExpress	Q5CZ79.
Family and domain databases
InterPro	IPR002110. ANK. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00023. Ank. 6 hits. [Graphical view]
PRINTS	PR01415. ANKYRIN.
SMART	SM00248. ANK. 6 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 4 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AN20B_HUMAN

Accession

Primary (citable) accession number: Q5CZ79
Secondary accession number(s): A6NC18

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	April 8, 2008
Last modified:	December 16, 2008
This is version 20 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)