Reviewed, UniProtKB/Swiss-Prot Q5DTI6 (CB067_MOUSE)

Names and origin

Protein names

Recommended name:
    Uncharacterized protein C2orf67 homolog

Gene names

Name:

Kiaa4189

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	991 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5DTI6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5DTI6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     412-417: GIVILE → VLLVFC
     418-991: Missing.

Notes: No experimental confirmation available.

Isoform 3 (identifier: Q5DTI6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     677-720: Missing.

Notes: No experimental confirmation available.

Isoform 4 (identifier: Q5DTI6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     365-368: NSST → YAKR
     369-991: Missing.

Notes: No experimental confirmation available.

Isoform 5 (identifier: Q5DTI6-5)

The sequence of this isoform differs from the canonical sequence as follows:
     412-446: Missing.

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 991	991	Uncharacterized protein C2orf67 homolog
Natural variations
	Alternative sequence	365 – 368	4	NSST → YAKR in isoform 4.
	Alternative sequence	369 – 991	623	Missing in isoform 4.
	Alternative sequence	412 – 446	35	Missing in isoform 5.
	Alternative sequence	412 – 417	6	GIVILE → VLLVFC in isoform 2.
	Alternative sequence	418 – 991	574	Missing in isoform 2.
	Alternative sequence	677 – 720	44	Missing in isoform 3.
Experimental info
	Sequence conflict	162	1	T → A in BAC38212. Ref.2
	Sequence conflict	204	1	S → T in BAC38212. Ref.2
	Sequence conflict	219	1	E → Q in BAC38212. Ref.2
	Sequence conflict	349	1	S → P in BAE42157. Ref.2
	Sequence conflict	353	1	V → L in BAC38212 and BAC38675. Ref.2
	Sequence conflict	894	1	A → P in BAC38675. Ref.2
	Sequence conflict	947	1	A → T in BAC38675. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: D0A36B7662258A11	FASTA	991	112,486
	10 20 30 40 50 60 MTPALKEATT KGICFSSLPN TMESDKMLCM ESPRTVDEKL KGGDTFSQML GFPTPEPTLN 70 80 90 100 110 120 TNFVNLKHFA SPQASKHFQT VLLMSSNSTL NKYNENYNQK KVMESNCSKL KNVLCNGSSI 130 140 150 160 170 180 QLSKICPSHS ENEFIKKELS DTTSQCMKDI QIVLDSNLTK DTNVDRLHLQ NCKWYQKNAL 190 200 210 220 230 240 LDKFTDTKIK KGLLQCTQKK IGPSHSDVPT SSSAAEKEEE VNARLLHCVS KQKILLSQAR 250 260 270 280 290 300 RTQKHLQMLL AKHVVKHYGQ QMKFSMKHQL PTMKIFHEPT TVLSNSLLEH TEIKPEVNIL 310 320 330 340 350 360 ASENKFWDDT NNGFSQCTAA EIQRFALSAT GLLSHVEEGL DSDATDSSSD DEVDEYTIRK 370 380 390 400 410 420 NVAVNSSTEW KWLVDRAQVG SRWTWLQAQI SELEYKIQQL TDIHRQIRAS KGIVILEECQ 430 440 450 460 470 480 LPKDILKKQI QFSNQAVSLN TSVNSQVPQR SEEPLPEHDF EMSPSSPTLL LRNIEKQSAQ 490 500 510 520 530 540 LTEIINSLIA PLNLSPTSSP LSSKSCSHKC LANGISRSAS ENLDELSSSS SWLLNQKHSK 550 560 570 580 590 600 KRRKDRTRLK SPSLAIMSTA ARTRPLQSFH KRKLYRLSPT FYWTPETLPS KEAFLSSTQT 610 620 630 640 650 660 PYTGSPFSWD NWEQSSRSHL LREQVSKLDS SFHPVLSLPS EIPLHLHFET LFKKTDMKGE 670 680 690 700 710 720 LAENQFVGDC LISPPPVQGT SSLNQWRNGY SPICKPQIRS QPSVQLLQGR KKRHLSETAL 730 740 750 760 770 780 AGERTRFEEF AFQRSEPGSH CNFTAVSNAN VTSRTQNPSS QNTSRRRLRS ESSYDIDNIV 790 800 810 820 830 840 IPMSLVAPAK LEKLQYKEIL TPRWRKVVLQ PLDEHNLNKE EIEDLSDDVF SLRHRKYEER 850 860 870 880 890 900 EQARWSLWEQ SKWHRRNNRA YSKNVEGQDL VLKEHSSELG SAQQGTAESP FELAAESHSL 910 920 930 940 950 960 CAQDSLSLND GQEDKSLRWE RRAFPLKDED TAALLCQDER KDQTGGASTA FHDEVFCSTT 970 980 990 PESGHPPKMQ LDGMEEYKSF GIGVTNVKRN R
	Isoform 2 [UniParc]. Checksum: B77E85CCF3D9E0C0		417	47,281
	10 20 30 40 50 60 MTPALKEATT KGICFSSLPN TMESDKMLCM ESPRTVDEKL KGGDTFSQML GFPTPEPTLN 70 80 90 100 110 120 TNFVNLKHFA SPQASKHFQT VLLMSSNSTL NKYNENYNQK KVMESNCSKL KNVLCNGSSI 130 140 150 160 170 180 QLSKICPSHS ENEFIKKELS DTTSQCMKDI QIVLDSNLTK DTNVDRLHLQ NCKWYQKNAL 190 200 210 220 230 240 LDKFTDTKIK KGLLQCTQKK IGPSHSDVPT SSSAAEKEEE VNARLLHCVS KQKILLSQAR 250 260 270 280 290 300 RTQKHLQMLL AKHVVKHYGQ QMKFSMKHQL PTMKIFHEPT TVLSNSLLEH TEIKPEVNIL 310 320 330 340 350 360 ASENKFWDDT NNGFSQCTAA EIQRFALSAT GLLSHVEEGL DSDATDSSSD DEVDEYTIRK 370 380 390 400 410 NVAVNSSTEW KWLVDRAQVG SRWTWLQAQI SELEYKIQQL TDIHRQIRAS KVLLVFC
	Isoform 3 [UniParc]. Checksum: 25257E3095C2EE5A		947	107,512
	10 20 30 40 50 60 MTPALKEATT KGICFSSLPN TMESDKMLCM ESPRTVDEKL KGGDTFSQML GFPTPEPTLN 70 80 90 100 110 120 TNFVNLKHFA SPQASKHFQT VLLMSSNSTL NKYNENYNQK KVMESNCSKL KNVLCNGSSI 130 140 150 160 170 180 QLSKICPSHS ENEFIKKELS DTTSQCMKDI QIVLDSNLTK DTNVDRLHLQ NCKWYQKNAL 190 200 210 220 230 240 LDKFTDTKIK KGLLQCTQKK IGPSHSDVPT SSSAAEKEEE VNARLLHCVS KQKILLSQAR 250 260 270 280 290 300 RTQKHLQMLL AKHVVKHYGQ QMKFSMKHQL PTMKIFHEPT TVLSNSLLEH TEIKPEVNIL 310 320 330 340 350 360 ASENKFWDDT NNGFSQCTAA EIQRFALSAT GLLSHVEEGL DSDATDSSSD DEVDEYTIRK 370 380 390 400 410 420 NVAVNSSTEW KWLVDRAQVG SRWTWLQAQI SELEYKIQQL TDIHRQIRAS KGIVILEECQ 430 440 450 460 470 480 LPKDILKKQI QFSNQAVSLN TSVNSQVPQR SEEPLPEHDF EMSPSSPTLL LRNIEKQSAQ 490 500 510 520 530 540 LTEIINSLIA PLNLSPTSSP LSSKSCSHKC LANGISRSAS ENLDELSSSS SWLLNQKHSK 550 560 570 580 590 600 KRRKDRTRLK SPSLAIMSTA ARTRPLQSFH KRKLYRLSPT FYWTPETLPS KEAFLSSTQT 610 620 630 640 650 660 PYTGSPFSWD NWEQSSRSHL LREQVSKLDS SFHPVLSLPS EIPLHLHFET LFKKTDMKGE 670 680 690 700 710 720 LAENQFVGDC LISPPPAGER TRFEEFAFQR SEPGSHCNFT AVSNANVTSR TQNPSSQNTS 730 740 750 760 770 780 RRRLRSESSY DIDNIVIPMS LVAPAKLEKL QYKEILTPRW RKVVLQPLDE HNLNKEEIED 790 800 810 820 830 840 LSDDVFSLRH RKYEEREQAR WSLWEQSKWH RRNNRAYSKN VEGQDLVLKE HSSELGSAQQ 850 860 870 880 890 900 GTAESPFELA AESHSLCAQD SLSLNDGQED KSLRWERRAF PLKDEDTAAL LCQDERKDQT 910 920 930 940 GGASTAFHDE VFCSTTPESG HPPKMQLDGM EEYKSFGIGV TNVKRNR
	Isoform 4 [UniParc]. Checksum: 11DFF4456E9ED2E6		368	41,457
	10 20 30 40 50 60 MTPALKEATT KGICFSSLPN TMESDKMLCM ESPRTVDEKL KGGDTFSQML GFPTPEPTLN 70 80 90 100 110 120 TNFVNLKHFA SPQASKHFQT VLLMSSNSTL NKYNENYNQK KVMESNCSKL KNVLCNGSSI 130 140 150 160 170 180 QLSKICPSHS ENEFIKKELS DTTSQCMKDI QIVLDSNLTK DTNVDRLHLQ NCKWYQKNAL 190 200 210 220 230 240 LDKFTDTKIK KGLLQCTQKK IGPSHSDVPT SSSAAEKEEE VNARLLHCVS KQKILLSQAR 250 260 270 280 290 300 RTQKHLQMLL AKHVVKHYGQ QMKFSMKHQL PTMKIFHEPT TVLSNSLLEH TEIKPEVNIL 310 320 330 340 350 360 ASENKFWDDT NNGFSQCTAA EIQRFALSAT GLLSHVEEGL DSDATDSSSD DEVDEYTIRK NVAVYAKR
	Isoform 5 [UniParc]. Checksum: AC118E0D59B65A9B		956	108,617
	10 20 30 40 50 60 MTPALKEATT KGICFSSLPN TMESDKMLCM ESPRTVDEKL KGGDTFSQML GFPTPEPTLN 70 80 90 100 110 120 TNFVNLKHFA SPQASKHFQT VLLMSSNSTL NKYNENYNQK KVMESNCSKL KNVLCNGSSI 130 140 150 160 170 180 QLSKICPSHS ENEFIKKELS DTTSQCMKDI QIVLDSNLTK DTNVDRLHLQ NCKWYQKNAL 190 200 210 220 230 240 LDKFTDTKIK KGLLQCTQKK IGPSHSDVPT SSSAAEKEEE VNARLLHCVS KQKILLSQAR 250 260 270 280 290 300 RTQKHLQMLL AKHVVKHYGQ QMKFSMKHQL PTMKIFHEPT TVLSNSLLEH TEIKPEVNIL 310 320 330 340 350 360 ASENKFWDDT NNGFSQCTAA EIQRFALSAT GLLSHVEEGL DSDATDSSSD DEVDEYTIRK 370 380 390 400 410 420 NVAVNSSTEW KWLVDRAQVG SRWTWLQAQI SELEYKIQQL TDIHRQIRAS KVPQRSEEPL 430 440 450 460 470 480 PEHDFEMSPS SPTLLLRNIE KQSAQLTEII NSLIAPLNLS PTSSPLSSKS CSHKCLANGI 490 500 510 520 530 540 SRSASENLDE LSSSSSWLLN QKHSKKRRKD RTRLKSPSLA IMSTAARTRP LQSFHKRKLY 550 560 570 580 590 600 RLSPTFYWTP ETLPSKEAFL SSTQTPYTGS PFSWDNWEQS SRSHLLREQV SKLDSSFHPV 610 620 630 640 650 660 LSLPSEIPLH LHFETLFKKT DMKGELAENQ FVGDCLISPP PVQGTSSLNQ WRNGYSPICK 670 680 690 700 710 720 PQIRSQPSVQ LLQGRKKRHL SETALAGERT RFEEFAFQRS EPGSHCNFTA VSNANVTSRT 730 740 750 760 770 780 QNPSSQNTSR RRLRSESSYD IDNIVIPMSL VAPAKLEKLQ YKEILTPRWR KVVLQPLDEH 790 800 810 820 830 840 NLNKEEIEDL SDDVFSLRHR KYEEREQARW SLWEQSKWHR RNNRAYSKNV EGQDLVLKEH 850 860 870 880 890 900 SSELGSAQQG TAESPFELAA ESHSLCAQDS LSLNDGQEDK SLRWERRAFP LKDEDTAALL 910 920 930 940 950 CQDERKDQTG GASTAFHDEV FCSTTPESGH PPKMQLDGME EYKSFGIGVT NVKRNR

References

[1]

"Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H. Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Fetal brain.

[2]

"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 311-991 (ISOFORM 5). Strain: C57BL/6J and NOD. Tissue: Head.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK220534 mRNA. Translation: BAD90312.1. Different initiation. AK081413 mRNA. Translation: BAC38212.1. AK082897 mRNA. Translation: BAC38675.1. Different initiation. AK170981 mRNA. Translation: BAE42157.1.
RefSeq	NP_001116210.1. NP_808313.3.
UniGene	Mm.383276 Mm.441295 Mm.461139
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000026004. Mus musculus. [Contig view]
GeneID	68691.
KEGG	mmu:68691.
Organism-specific databases
MGI	MGI:1915941. 1110028C15Rik.
Rouge	Search...
Phylogenomic databases
HOGENOM	Q5DTI6.
HOVERGEN	Q5DTI6.
Gene expression databases
CleanEx	MM_1110028C15RIK.
Family and domain databases
ProDom	Q5DTI6. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

CB067_MOUSE

Accession

Primary (citable) accession number: Q5DTI6
Secondary accession number(s): Q3TC00, Q8BNM1, Q8C4R5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	July 22, 2008
This is version 24 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)