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Reviewed, UniProtKB/Swiss-Prot Q5FYA8 (ARSH_HUMAN)

Last modified July 22, 2008. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Arylsulfatase H
      Short name(s)=ASH
    EC=3.1.6.-
Gene names
Name: ARSH
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length562 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Cofactor

Binds 1 calcium ion per subunit By similarity.

Subcellular location

Membrane; Multi-pass membrane proteinPotential.

Sequence similarities

Belongs to the sulfatase family.

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Ontologies

Keywords

   Cellular componentMembrane
   DomainTransmembrane
   LigandCalcium
Metal-binding
   Molecular functionHydrolase

Gene Ontology (GO)

   Molecular functionarylsulfatase activity Ref.1

Traceable author statement. Source: HGNC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 562562Arylsulfatase H

Regions

Transmembrane167 – 18721 Potential
Transmembrane189 – 20921 Potential

Sites

Active site1171 By similarity
Metal binding151Calcium By similarity
Metal binding161Calcium By similarity
Metal binding551Calcium (via 3-oxoalanine) By similarity
Metal binding3231Calcium By similarity
Metal binding3241Calcium By similarity

Amino acid modifications

Modified residue5513-oxoalanine (Cys) By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q5FYA8-1 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: E7428B679C76E78F

FASTA56263,525
        10         20         30         40         50         60 
MTRNARPNIV LLMADDLGVG DLCCYGNNSV STPNIDRLAS EGVRLTQHLA AASMCTPSRA 

        70         80         90        100        110        120 
AFLTGRYPIR SGMVSAYNLN RAFTWLGGSG GLPTNETTFA KLLQHRGYRT GLIGKWHLGL 

       130        140        150        160        170        180 
SCASRNDHCY HPLNHGFHYF YGVPFGLLSD CQASKTPELH RWLRIKLWIS TVALALVPFL 

       190        200        210        220        230        240 
LLIPKFARWF SVPWKVIFVF ALLAFLFFTS WYSSYGFTRR WNCILMRNHE IIQQPMKEEK 

       250        260        270        280        290        300 
VASLMLKEAL AFIERYKREP FLLFFSFLHV HTPLISKKKF VGRSKYGRYG DNVEEMDWMV 

       310        320        330        340        350        360 
GKILDALDQE RLANHTLVYF TSDNGGHLEP LDGAVQLGGW NGIYKGGKGM GGWEGGIRVP 

       370        380        390        400        410        420 
GIFRWPSVLE AGRVINEPTS LMDIYPTLSY IGGGILSQDR VIDGQNLMPL LEGRASHSDH 

       430        440        450        460        470        480 
EFLFHYCGVY LHTVRWHQKD CATVWKAHYV TPKFYPEGTG ACYGSGICSC SGDVTYHDPP 

       490        500        510        520        530        540 
LLFDISRDPS EALPLNPDNE PLFDSVIKKM EAAIREHRRT LTPVPQQFSV FNTIWKPWLQ 

       550        560 
PCCGTFPFCG CDKEDDILPM AP

« Hide

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References

[1]"Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship."
Sardiello M., Annunziata I., Roma G., Ballabio A.
Hum. Mol. Genet. 14:3203-3217(2005) [PubMed: 16174644] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

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Cross-references

Sequence databases

AY875940 mRNA. Translation: AAW66668.1.
RefSeqNP_001011719.1.
UniGeneHs.351533

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSG00000205667. Homo sapiens. [Contig view]
GeneID347527.
KEGGhsa:347527.

Organism-specific databases

HGNCHGNC:32488. ARSH.
MIM300586. gene.
GenAtlasSearch...
GeneCardsSearch...
GeneLynxSearch...

Phylogenomic databases

HOGENOMQ5FYA8.
HOVERGENQ5FYA8.

Gene expression databases

CleanExHS_ARSH.

Family and domain databases

InterProIPR017849. Alkaline_Pase-like_a/b/a.
IPR000917. Sulphatase.
[Graphical view]
Gene3DG3DSA:3.40.720.10. Alk_phosphtse. 1 hit.
PfamPF00884. Sulfatase. 1 hit.
[Graphical view]
PROSITEPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]
ProDomQ5FYA8.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

SOURCESearch...
ProtoNetSearch...

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Entry information

Entry nameARSH_HUMAN
AccessionPrimary (citable) accession number: Q5FYA8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: March 1, 2005
Last modified: July 22, 2008
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents