Reviewed, UniProtKB/Swiss-Prot Q5FYB0 (ARSJ_HUMAN)

Names and origin

Protein names

Recommended name:
    Arylsulfatase J
      Short name=ASJ
    EC=3.1.6.-

Gene names

Name:	ARSJ
ORF Names:	UNQ372/PRO708

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	599 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Cofactor	Binds 1 calcium ion per subunit By similarity.
Subcellular location	SecretedPotential.
Post-translational modification	The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity By similarity.
Sequence similarities	Belongs to the sulfatase family.
Sequence caution	The sequence AAQ89010.1 differs from that shown. Reason: Frameshift at position 425.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Ligand	Calcium Metal-binding
Molecular function	Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Molecular function	arylsulfatase activity Ref.1 Traceable author statement. Source: HGNC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 49	49	Potential
	Chain	50 – 599	550	Arylsulfatase J
Sites
	Active site	178	1	By similarity
	Metal binding	84	1	Calcium By similarity
	Metal binding	85	1	Calcium By similarity
	Metal binding	122	1	Calcium; via 3-oxoalanine By similarity
	Metal binding	327	1	Calcium By similarity
	Metal binding	328	1	Calcium By similarity
Amino acid modifications
	Modified residue	122	1	3-oxoalanine (Cys) By similarity
	Glycosylation	157	1	N-linked (GlcNAc...) Potential
	Glycosylation	306	1	N-linked (GlcNAc...) Potential
	Glycosylation	318	1	N-linked (GlcNAc...) Potential
	Glycosylation	431	1	N-linked (GlcNAc...) Potential
	Glycosylation	497	1	N-linked (GlcNAc...) Potential
	Glycosylation	527	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	182	1	Y → N in AAQ89010. Ref.2
	Sequence conflict	263	1	I → T in AAQ89010. Ref.2
	Sequence conflict	495	1	L → P in AAH89445. Ref.3
	Sequence conflict	576	1	S → K in AAH89445. Ref.3
	Sequence conflict	590 – 599	10	STCHSGVTCG → KPANLAR Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q5FYB0-1 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: 1548898E95C43A7A	FASTA	599	67,235
	10 20 30 40 50 60 MAPRGCAGHP PPPSPQACVC PGKMLAMGAL AGFWILCLLT YGYLSWGQAL EEEEEGALLA 70 80 90 100 110 120 QAGEKLEPST TSTSQPHLIF ILADDQGFRD VGYHGSEIKT PTLDKLAAEG VKLENYYVQP 130 140 150 160 170 180 ICTPSRSQFI TGKYQIHTGL QHSIIRPTQP NCLPLDNATL PQKLKEVGYS THMVGKWHLG 190 200 210 220 230 240 FYRKECMPTR RGFDTFFGSL LGSGDYYTHY KCDSPGMCGY DLYENDNAAW DYDNGIYSTQ 250 260 270 280 290 300 MYTQRVQQIL ASHNPTKPIF LYIAYQAVHS PLQAPGRYFE HYRSIININR RRYAAMLSCL 310 320 330 340 350 360 DEAINNVTLA LKTYGFYNNS IIIYSSDNGG QPTAGGSNWP LRGSKGTYWE GGIRAVGFVH 370 380 390 400 410 420 SPLLKNKGTV CKELVHITDW YPTLISLAEG QIDEDIQLDG YDIWETISEG LRSPRVDILH 430 440 450 460 470 480 NIDPIYTKAK NGSWAAGYGI WNTAIQSAIR VQHWKLLTGN PGYSDWVPPQ SFSNLGPNRW 490 500 510 520 530 540 HNERITLSTG KSVWLFNITA DPYERVDLSN RYPGIVKKLL RRLSQFNKTA VPVRYPPKDP 550 560 570 580 590 RSNPRLNGGV WGPWYKEETK KKKPSKNQAE KKQKKSKKKK KKQQKAVSGS TCHSGVTCG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship." Sardiello M., Annunziata I., Roma G., Ballabio A. Hum. Mol. Genet. 14:3203-3217(2005) [PubMed: 16174644] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-578. Tissue: Chondrosarcoma.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY875938 mRNA. Translation: AAW66666.1. AY358647 mRNA. Translation: AAQ89010.1. Frameshift. BC089445 mRNA. Translation: AAH89445.1.
RefSeq	NP_078866.3.
UniGene	Hs.22895
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000180801. Homo sapiens. [Contig view]
GeneID	79642.
KEGG	hsa:79642.
Organism-specific databases
HGNC	HGNC:26286. ARSJ.
MIM	610010. gene.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q5FYB0.
Gene expression databases
ArrayExpress	Q5FYB0.
CleanEx	HS_ARSJ.
Family and domain databases
InterPro	IPR017849. Alkaline_Pase-like_a/b/a. IPR000917. Sulphatase. [Graphical view]
Gene3D	G3DSA:3.40.720.10. Alk_phosphtse. 1 hit.
Pfam	PF00884. Sulfatase. 1 hit. [Graphical view]
PROSITE	PS00523. SULFATASE_1. 1 hit. PS00149. SULFATASE_2. 1 hit. [Graphical view]
ProDom	Q5FYB0. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

ARSJ_HUMAN

Accession

Primary (citable) accession number: Q5FYB0
Secondary accession number(s): Q5FWE4, Q6UWT9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2005
Last sequence update:	March 1, 2005
Last modified:	September 2, 2008
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)