Reviewed, UniProtKB/Swiss-Prot Q5IS98 (ACM5_SAIBB)

Names and origin

Protein names

Recommended name:
    Muscarinic acetylcholine receptor M5

Gene names

Name:

CHRM5

Organism

Saimiri boliviensis boliviensis (Bolivian squirrel monkey)

Taxonomic identifier

39432 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Platyrrhini › Cebidae › Saimiriinae › Saimiri

Protein attributes

Sequence length	532 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Subcellular location	Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein Phosphoprotein
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 532	532	Muscarinic acetylcholine receptor M5
Regions
	Topological domain	1 – 29	29	Extracellular Potential
	Transmembrane	30 – 53	24	1 Potential
	Topological domain	54 – 66	13	Cytoplasmic Potential
	Transmembrane	67 – 87	21	2 Potential
	Topological domain	88 – 104	17	Extracellular Potential
	Transmembrane	105 – 126	22	3 Potential
	Topological domain	127 – 146	20	Cytoplasmic Potential
	Transmembrane	147 – 169	23	4 Potential
	Topological domain	170 – 191	22	Extracellular Potential
	Transmembrane	192 – 214	23	5 Potential
	Topological domain	215 – 443	229	Cytoplasmic Potential
	Transmembrane	444 – 464	21	6 Potential
	Topological domain	465 – 478	14	Extracellular Potential
	Transmembrane	479 – 498	20	7 Potential
	Topological domain	499 – 532	34	Cytoplasmic Potential
Amino acid modifications
	Modified residue	501	1	Phosphothreonine Potential
	Modified residue	505	1	Phosphothreonine Potential
	Glycosylation	8	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5IS98-1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 4B09E40A3940A8F8	FASTA	532	59,873
	10 20 30 40 50 60 MEGDSYGNAT TINGTPVNHQ PLERHRLWEV ITIAAVTAVV SLITIVGNVL VMISFKVNSQ 70 80 90 100 110 120 LKTVNNYYLL SLACADLIIG IFSMNLYTTY ILMGRWALGS LACDLWLALD YVASNASVMN 130 140 150 160 170 180 LLVISFDRYF SITRPLTYRA KRTPKRAGIM IGLAWLISFI LWAPAILCWQ YLVGKRTVPP 190 200 210 220 230 240 DECQIQFLSE PTITFGTAIA AFYIPVSVMT ILYCRIYRET EKRTKDLADL QGSVSVTKAE 250 260 270 280 290 300 KRKPAHRALF RSCFRCPRPT LVQRERNQAS RSSSHRSTSI TGKPSQATGP STNWAKAEEL 310 320 330 340 350 360 TTCSSYPSSE DEDKPATDPV LQVVYKSQGK ESPGEEFSAE EAEETFVKGQ TDKNDCDSPD 370 380 390 400 410 420 YFLSPAAAHR PKSQQCVAYK FQLVVKADGT QETNNGCHKV KIMPCSFPVA KEPSTKGLSP 430 440 450 460 470 480 NLSHQMTKRK RMVLVKERKA AQTLSAILLA FIITWTPYNI MVLVSTFCDK CVPVALWHLG 490 500 510 520 530 YWLCYVNSTV NPICYALCNR TFRKTFKMLL LCQWKKKKVE EKLYWQGNSK LP

References

[1]	"Accelerated evolution of nervous system genes in the origin of Homo sapiens." Dorus S., Vallender E.J., Evans P.D., Anderson J.R., Gilbert S.L., Mahowald M., Wyckoff G.J., Malcom C.M., Lahn B.T. Cell 119:1027-1040(2004) [PubMed: 15620360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY665230 mRNA. Translation: AAV74268.1.
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Phylogenomic databases
HOVERGEN	Q5IS98.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR000502. Musac_M5_rcpt. IPR000995. Musac_rcpt. [Graphical view]
PANTHER	PTHR19266:SF36. Musac_M5_rcpt. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00243. MUSCARINICR. PR00542. MUSCRINICM5R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProDom	Q5IS98. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ACM5_SAIBB

Accession

Primary (citable) accession number: Q5IS98

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	February 15, 2005
Last modified:	July 22, 2008
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)