Reviewed, UniProtKB/Swiss-Prot Q5JX69 (CT107_HUMAN)

Names and origin

Protein names

Recommended name:
    Uncharacterized protein C20orf107

Gene names

Name:

C20orf107

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location

Membrane; Single-pass type I membrane proteinPotential.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 171	152	Uncharacterized protein C20orf107		PRO_0000236040
Regions
	Topological domain	20 – 52	33	Extracellular Potential
	Transmembrane	53 – 73	21	Potential
	Topological domain	74 – 171	98	Cytoplasmic Potential
Amino acid modifications
	Modified residue	141	1	Phosphoserine
	Modified residue	143	1	Phosphoserine
Natural variations
	Natural variant	129	1	E → A: dbSNP rs2296129.		VAR_033762
Experimental info
	Sequence conflict	37 – 38	2	PC → QY in AAI05793. Ref.2
	Sequence conflict	74	1	Q → K in AAI05793. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q5JX69-1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 8B24B54EB89505A8	FASTA	171	19,499
	10 20 30 40 50 60 MWTLKSSLVL LLCLTCSYAF MFSSLRQKTS EPQGKVPCGE HFRIRQNLPE HTQGWLGSKW 70 80 90 100 110 120 LWLLFAVVPF VILQCQRDSE KNKEQSPPGL RGFPFRTPLK KNQNASLYKD CVFNTLNELE 130 140 150 160 170 VELLKFVSEV QNLKGAMATG SGSNLKLRRS EMPADPYHVT ICKIWGEESS S

References

[1]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation." Ficarro S., Chertihin O., Westbrook V.A., White F., Jayes F., Kalab P., Marto J.A., Shabanowitz J., Herr J.C., Hunt D.F., Visconti P.E. J. Biol. Chem. 278:11579-11589(2003) [PubMed: 12509440] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-141 AND SER-143, MASS SPECTROMETRY. Tissue: Sperm.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL109806 Genomic DNA. Translation: CAI19291.1. BC105792 mRNA. Translation: AAI05793.1.
RefSeq	NP_001013668.2.
UniGene	Hs.287759
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q5JX69.
Genome annotation databases
Ensembl	ENSG00000213714. Homo sapiens. [Contig view]
GeneID	388799.
KEGG	hsa:388799.
Organism-specific databases
HGNC	HGNC:16101. C20orf107.
PharmGKB	PA25646.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q5JX69.
Gene expression databases
CleanEx	HS_C20orf107.
GermOnline	ENSG00000124103. Homo sapiens.
Family and domain databases
BLOCKS	Search...
ProtoNet	Search...
Other Resources
NextBio	102369.

Entry information

Entry name

CT107_HUMAN

Accession

Primary (citable) accession number: Q5JX69
Secondary accession number(s): Q3KRB5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	February 15, 2005
Last modified:	November 4, 2008
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)