Reviewed, UniProtKB/Swiss-Prot Q5JX71 (CT106_HUMAN)

Names and origin

Protein names

Recommended name:
    Uncharacterized protein C20orf106

Gene names

Name:

C20orf106

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane proteinPotential.
Sequence caution	The sequence AAH29411.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Coiled coil Signal Transmembrane
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 171	152	Uncharacterized protein C20orf106		PRO_0000264155
Regions
	Topological domain	20 – 52	33	Extracellular Potential
	Transmembrane	53 – 73	21	Potential
	Topological domain	74 – 171	98	Cytoplasmic Potential
	Coiled coil	114 – 139	26	Potential
Natural variations
	Natural variant	66	1	V → A: dbSNP rs707554.		VAR_029621
	Natural variant	95	1	L → F: dbSNP rs1054343.		VAR_033761
	Natural variant	117	1	M → K: dbSNP rs1054349.		VAR_029622
	Natural variant	135	1	R → G: dbSNP rs1054358.		VAR_029623
	Natural variant	146	1	R → K: dbSNP rs1054361.		VAR_029624
Experimental info
	Sequence conflict	98	1	P → L in AAH29411. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q5JX71-1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 2CBB21C35AF9623A	FASTA	171	19,603
	10 20 30 40 50 60 MWTLKSSLVL LLCLTCSYAF MFSSLRQKTS EPQGKVQYGE HFRIRQNLPE HTQGWLGSKW 70 80 90 100 110 120 LWLLFVVVPF VILQCQRDSE KNKEQSPPGL RGGQLHSPLK KKRNASPNKD CAFNTLMELE 130 140 150 160 170 VELMKFVSKV RNLKRAMATG SGSNLRLRKS EMPADPYHVT ICEIWGEESS S

References

[1]

"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL109806 Genomic DNA. Translation: CAI19289.1. BC029411 mRNA. Translation: AAH29411.1. Sequence problems. BC107704 mRNA. Translation: AAI07705.1.
RefSeq	NP_001012989.2.
UniGene	Hs.504907
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q5JX71.
Genome annotation databases
Ensembl	ENSG00000124103. Homo sapiens. [Contig view]
GeneID	200232.
KEGG	hsa:200232.
Organism-specific databases
GeneCards	GC20P054532.
HGNC	HGNC:16100. C20orf106.
PharmGKB	PA134974173.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q5JX71.
Gene expression databases
CleanEx	HS_C20orf106.
GermOnline	ENSG00000124103. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	89874.

Entry information

Entry name

CT106_HUMAN

Accession

Primary (citable) accession number: Q5JX71
Secondary accession number(s): Q05C43

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	February 15, 2005
Last modified:	December 16, 2008
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)