Reviewed, UniProtKB/Swiss-Prot Q5L512 (SYA_CHLAB)

Names and origin

Protein names

Recommended name:
    Alanyl-tRNA synthetase
    EC=6.1.1.7
Alternative name(s):
    Alanine--tRNA ligase
      Short name(s)=AlaRS

Gene names

Name:	alaS
Ordered Locus Names:	CAB842

Organism

Chlamydophila abortus [Complete proteome] [HAMAP]

Taxonomic identifier

83555 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydophila

Protein attributes

Sequence length	875 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	alanyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP alanine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 875	875	Alanyl-tRNA synthetase

Sequences

	Sequence		Length	Mass (Da)
	Q5L512-1 [UniParc]. Last modified June 21, 2005. Version 1. Checksum: 9C73A9E0DB53DA08	FASTA	875	98,407
	10 20 30 40 50 60 MLSNTLRSNF LKFYANRHHT IVSSSPVFPH NDPSILFTNA GMNQFKDIFL NKETVSYSRA 70 80 90 100 110 120 TTSQKCIRAG GKHNDLDNVG HTSRHLTFFE MLGNFSFGDY FKEQAIAFAW EVSLSVFNFD 130 140 150 160 170 180 PDRIYATVHE KDDEAFALWE QHLPSERIFR LTDKDNFWSM AETGPCGYCS ELLFDRGESF 190 200 210 220 230 240 GTATSPLEDS EGERFLEYWN LVFMEFNRSA EGSLLALPNK HVDTGAGLER LVSIISGTNT 250 260 270 280 290 300 VFEADVLRLL ISKTETLSGE KYHADEPLGA AFRVIADHVR SLSFAIVDGL IPGNTERGYV 310 320 330 340 350 360 LRKILRRSVN YGKRLGFTQP FLAEIVPALV DAMGEAYPEL RLSVSQIQEV MTIEEENYFK 370 380 390 400 410 420 SLHRGGNLLQ QVLKSSSSSS TISGEDAFKL KDTYGLPLDE IALLAKDYNF SVDLDTFYQL 430 440 450 460 470 480 EKEAKERSRK NVIKSHNATD TVYDALSLGE NSTFVGYHDL SCDTFIEAII KNGEQVSYLK 490 500 510 520 530 540 EKEKGILILK ETPFYAEKGG QVGDSGEIFC SDGTFIVSHT TSPKAGMVIH HGEVSQGQLH 550 560 570 580 590 600 SAQAVTAQVH CLRRKNISNN HTGCHLLHKA LEMTLGDHIR QAGSFVDDTK IRLDFTHPKA 610 620 630 640 650 660 IAPEDLASIE LLVNEKIREN HRVETREAAY SDVMNSKEIK QFFGDKYSDV VRVVSAGFSH 670 680 690 700 710 720 ELCGGTHADF TGDLGYFRIL KEHAVATGIR RIEAVTGKEA EVLARQDNQD LNEIALILQS 730 740 750 760 770 780 PRDQILNKLQ NILDEKKEQT KLISDLENKL IYSLLDKVID RCQQIEDVSY FIYHLPESES 790 800 810 820 830 840 HRLQQYANCL HQKIPVRLVS LWTTQKNGKY IIFSRISDDL VKQGLKAKDL LQVLLTPCGG 850 860 870 RWGGKDIFAQ GSADSLPQAD ILNNTLCQWI STQLI

References

[1]

"The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation." Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D., Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D., Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A., Price C., Barrell B.G., Parkhill J., Longbottom D. Genome Res. 15:629-640(2005) [PubMed: 15837807] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S26/3.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR848038 Genomic DNA. Translation: CAH64283.1.
RefSeq	YP_220230.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3337552.
GenomeReviews	Gene locus CAB842 in contig CR848038_GR.
KEGG	cab:CAB842.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5L512.
Enzyme and pathway databases
BioCyc	CABO218497:CAB842-MON.
Family and domain databases
HAMAP	MF_00036. [Tree]
InterPro	IPR002318. Ala-tRNA-synth_IIc. IPR003156. Pesterase_DHHA1. IPR012947. tRNA_SAD. [Graphical view]
Pfam	PF02272. DHHA1. 1 hit. PF01411. tRNA-synt_2c. 1 hit. PF07973. tRNA_SAD. 1 hit. [Graphical view]
PRINTS	PR00980. TRNASYNTHALA.
TIGRFAMs	TIGR00344. alaS. 1 hit.
PROSITE	PS50860. AA_TRNA_LIGASE_II_ALA. 1 hit. [Graphical view]
ProDom	Q5L512. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

SYA_CHLAB

Accession

Primary (citable) accession number: Q5L512

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	June 21, 2005
Last modified:	July 22, 2008
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)