Reviewed, UniProtKB/Swiss-Prot Q5NCX5 (K1787_MOUSE)

Names and origin

Protein names

Recommended name:
    NHR domain-containing protein KIAA1787

Gene names

Name:

Kiaa1787

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	1563 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities	Contains 6 NHR (neuralized homology repeat) domains.
Sequence caution	The sequence CAI35150.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Repeat
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5NCX5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5NCX5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     245-266: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 1563	1563	NHR domain-containing protein KIAA1787
Regions
	Domain	43 – 209	167	NHR 1
	Domain	319 – 486	168	NHR 2
	Domain	522 – 688	167	NHR 3
	Domain	718 – 886	169	NHR 4
	Domain	915 – 1087	173	NHR 5
	Domain	1132 – 1295	164	NHR 6
Natural variations
	Alternative sequence	245 – 266	22	Missing in isoform 2.
Experimental info
	Sequence conflict	1247	1	L → M in BAE33965. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: 65F86EC95429B6C0	FASTA	1,563	167,637
	10 20 30 40 50 60 MAAGSGGSGG SGAGPGPGPG PGGGGGPGSS GPGLGSGGGL GGGGELHPRT GRLVSLSACG 70 80 90 100 110 120 RTARRQQPGQ EFNHGLVLSR EPLRDGRVFT VRIDRKVNSW SGSIEIGVTA LDPSVLDFPS 130 140 150 160 170 180 SATGLKGGSW VVSGCSVLRD GRSVLEEYGQ DLDQLVEGDR VGVERTATGE LRLWVNGRDC 190 200 210 220 230 240 GVAATGLPAR VWAVVDLYGK CTQITVLPSE PGFSPPTPVP TPPLEPLAPP EDSALLEQGT 250 260 270 280 290 300 SVDEAFMVSP AQARPETFPN SLDSHNDFAS MELSEVVSNA ILSAYNGGLL NVSLSSPPAG 310 320 330 340 350 360 DGLASSGPAT SPILTSNDAL LFHEKCGTLI KLSNNNKTAE RRRPLDEFNN GVVMTNRPLR 370 380 390 400 410 420 DNEMFEIRID KLVDKWSGSI EIGVTTHNPN SLEYPATMTN LQSGTIMMSG CGILTNGKGT 430 440 450 460 470 480 RREYCEFSLD ELQEGDHIGL TRKSNSALHF FINGIDQGVA TPLTPPVVYG VVDLYGMAVK 490 500 510 520 530 540 VTIVHNNNHS DRLRRNNAIL RALSPEGALR RAAPAAQAEP ERLLFHPNCG QKAAITHEGR 550 560 570 580 590 600 TALRPHATDD FNHGVVLSSR ALRDGEVFQV RIDKMVDKWA GSIEIGVTTH NPAYLQLPST 610 620 630 640 650 660 MTNLRSGTWM MTGNGVMHNG TTILDEYGHN LDRLKAGDTV GVVRREDGTL HFFVNGMTQG 670 680 690 700 710 720 PAAWNVPPGV YAVVDLYGQA AQATIVDDVE VPPVSEPLPE GNNQMSPSSP SSAAGGSDLR 730 740 750 760 770 780 FHQLHGSNAV ITNGGRTALR HNCRSEFNDA IVISNRALRD GELFEIVIQK MVDRWSGSIE 790 800 810 820 830 840 AGVTAIRPED LEFPNTMTDI DYDTWMLSGT AIMQDGNTMR NNYGCDLDAL GTGARIGMMR 850 860 870 880 890 900 TAKGDLHYFI NGQDQGAACS GLPPGKEVYA VVDLYGQCVQ VSITNATGPM DNSLATSNTA 910 920 930 940 950 960 TEKSFPLHSP VAGVAHRFHS MCGKNVTLEE DGTRAVRVAG YAHGLVFSTK ELKAEEVFEV 970 980 990 1000 1010 1020 KVEELDEKWA GSLRLGLTTL APEDMGPGAG SGPGLPPSLP ELRTKTTWMV SSCEVRRDGH 1030 1040 1050 1060 1070 1080 LQRMNYGRNL ERLGVGSRVG IRRCADDTMH ILVDGEDMGP AAAGIAKNVW AVLDLYGPVR 1090 1100 1110 1120 1130 1140 SVAIVSSTRL EEPEGTQPPS PSSDTGSEVE EDDEVEEQGL RGQNQVGIVP TALEFLENHG 1150 1160 1170 1180 1190 1200 KNILLSNGNR TATRVASYNQ GIVVISQPLV PHMLVQVRID FLNRQWTSSL VLGVITCPPE 1210 1220 1230 1240 1250 1260 RLNFPASACA LKRAAWLLRG RGVFHNGLKI CEKFGPNLDT CPEGTILGLR LDSSGGLHLH 1270 1280 1290 1300 1310 1320 INGVDQGVAV PDVPQPCHAL VDLYGQCEQV TIVSPDPGTA SGKIAGTQGD MEKADMVDGI 1330 1340 1350 1360 1370 1380 KESVCWGPPP AASPLKSCEY HALCSRFQEL LLLPEDYFMP PPKRSLCYCE SCRKLRGDEA 1390 1400 1410 1420 1430 1440 HRRRGEPPRE YALPFGWCRF NLRVNPHLEA GTLTKKWHMA YHGSSVAVVR RVLDRGELGA 1450 1460 1470 1480 1490 1500 GTTSILSCRP LKGEPGVGFE EPGENCAPPR EEQPPPVLLS PSLQYAGAEM LASKVQFRDP 1510 1520 1530 1540 1550 1560 KSQRTHQAQV AFQVCVRPGS YTPGPPSAAL RELPDQHFSP SELEWVTKEK GATLLYALLV RVE
	Isoform 2 [UniParc]. Checksum: 08AA3BAF649E8C72		1,541	165,239
	10 20 30 40 50 60 MAAGSGGSGG SGAGPGPGPG PGGGGGPGSS GPGLGSGGGL GGGGELHPRT GRLVSLSACG 70 80 90 100 110 120 RTARRQQPGQ EFNHGLVLSR EPLRDGRVFT VRIDRKVNSW SGSIEIGVTA LDPSVLDFPS 130 140 150 160 170 180 SATGLKGGSW VVSGCSVLRD GRSVLEEYGQ DLDQLVEGDR VGVERTATGE LRLWVNGRDC 190 200 210 220 230 240 GVAATGLPAR VWAVVDLYGK CTQITVLPSE PGFSPPTPVP TPPLEPLAPP EDSALLEQGT 250 260 270 280 290 300 SVDEDFASME LSEVVSNAIL SAYNGGLLNV SLSSPPAGDG LASSGPATSP ILTSNDALLF 310 320 330 340 350 360 HEKCGTLIKL SNNNKTAERR RPLDEFNNGV VMTNRPLRDN EMFEIRIDKL VDKWSGSIEI 370 380 390 400 410 420 GVTTHNPNSL EYPATMTNLQ SGTIMMSGCG ILTNGKGTRR EYCEFSLDEL QEGDHIGLTR 430 440 450 460 470 480 KSNSALHFFI NGIDQGVATP LTPPVVYGVV DLYGMAVKVT IVHNNNHSDR LRRNNAILRA 490 500 510 520 530 540 LSPEGALRRA APAAQAEPER LLFHPNCGQK AAITHEGRTA LRPHATDDFN HGVVLSSRAL 550 560 570 580 590 600 RDGEVFQVRI DKMVDKWAGS IEIGVTTHNP AYLQLPSTMT NLRSGTWMMT GNGVMHNGTT 610 620 630 640 650 660 ILDEYGHNLD RLKAGDTVGV VRREDGTLHF FVNGMTQGPA AWNVPPGVYA VVDLYGQAAQ 670 680 690 700 710 720 ATIVDDVEVP PVSEPLPEGN NQMSPSSPSS AAGGSDLRFH QLHGSNAVIT NGGRTALRHN 730 740 750 760 770 780 CRSEFNDAIV ISNRALRDGE LFEIVIQKMV DRWSGSIEAG VTAIRPEDLE FPNTMTDIDY 790 800 810 820 830 840 DTWMLSGTAI MQDGNTMRNN YGCDLDALGT GARIGMMRTA KGDLHYFING QDQGAACSGL 850 860 870 880 890 900 PPGKEVYAVV DLYGQCVQVS ITNATGPMDN SLATSNTATE KSFPLHSPVA GVAHRFHSMC 910 920 930 940 950 960 GKNVTLEEDG TRAVRVAGYA HGLVFSTKEL KAEEVFEVKV EELDEKWAGS LRLGLTTLAP 970 980 990 1000 1010 1020 EDMGPGAGSG PGLPPSLPEL RTKTTWMVSS CEVRRDGHLQ RMNYGRNLER LGVGSRVGIR 1030 1040 1050 1060 1070 1080 RCADDTMHIL VDGEDMGPAA AGIAKNVWAV LDLYGPVRSV AIVSSTRLEE PEGTQPPSPS 1090 1100 1110 1120 1130 1140 SDTGSEVEED DEVEEQGLRG QNQVGIVPTA LEFLENHGKN ILLSNGNRTA TRVASYNQGI 1150 1160 1170 1180 1190 1200 VVISQPLVPH MLVQVRIDFL NRQWTSSLVL GVITCPPERL NFPASACALK RAAWLLRGRG 1210 1220 1230 1240 1250 1260 VFHNGLKICE KFGPNLDTCP EGTILGLRLD SSGGLHLHIN GVDQGVAVPD VPQPCHALVD 1270 1280 1290 1300 1310 1320 LYGQCEQVTI VSPDPGTASG KIAGTQGDME KADMVDGIKE SVCWGPPPAA SPLKSCEYHA 1330 1340 1350 1360 1370 1380 LCSRFQELLL LPEDYFMPPP KRSLCYCESC RKLRGDEAHR RRGEPPREYA LPFGWCRFNL 1390 1400 1410 1420 1430 1440 RVNPHLEAGT LTKKWHMAYH GSSVAVVRRV LDRGELGAGT TSILSCRPLK GEPGVGFEEP 1450 1460 1470 1480 1490 1500 GENCAPPREE QPPPVLLSPS LQYAGAEMLA SKVQFRDPKS QRTHQAQVAF QVCVRPGSYT 1510 1520 1530 1540 PGPPSAALRE LPDQHFSPSE LEWVTKEKGA TLLYALLVRV E

References

[1]	The mouse genome sequencing consortium Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 19-1563 (ISOFORM 1). Strain: NOD. Tissue: Spleen.
[3]	"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H. DNA Res. 11:205-218(2004) [PubMed: 15368895] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 142-1563 (ISOFORM 2). Tissue: Embryo.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 936-1563. Tissue: Eye.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL596185 Genomic DNA. Translation: CAI35149.1. AL596185 Genomic DNA. Translation: CAI35150.1. Sequence problems. AK157107 mRNA. Translation: BAE33965.1. AK173264 mRNA. Translation: BAD32542.1. BC023037 mRNA. Translation: AAH23037.1.
RefSeq	NP_001013432.1.
UniGene	Mm.268347
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000047284. Mus musculus. [Contig view]
GeneID	216860.
KEGG	mmu:216860.
Organism-specific databases
MGI	MGI:1921092. 0610025P10Rik.
Rouge	Search...
Phylogenomic databases
HOGENOM	Q5NCX5.
HOVERGEN	Q5NCX5.
Gene expression databases
ArrayExpress	Q5NCX5.
CleanEx	MM_0610025P10RIK.
Family and domain databases
InterPro	IPR006573. Neu_Z. [Graphical view]
Pfam	PF07177. Neuralized. 6 hits. [Graphical view]
SMART	SM00588. NEUZ. 6 hits. [Graphical view]
PROSITE	PS51065. NHR. 6 hits. [Graphical view]
ProDom	Q5NCX5. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

K1787_MOUSE

Accession

Primary (citable) accession number: Q5NCX5
Secondary accession number(s): Q3U090 , Q5NCX4, Q69ZA2, Q8R1V5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	February 1, 2005
Last modified:	July 22, 2008
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)