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Reviewed, UniProtKB/Swiss-Prot Q5R949 (ACM1_PONAB)

Last modified July 22, 2008. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Muscarinic acetylcholine receptor M1
Gene names
Name: CHRM1
OrganismPongo abelii (Sumatran orangutan)
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

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Protein attributes

Sequence length460 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

Subunit structure

Interacts with GPRASP2 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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Ontologies

Keywords

   Cellular componentCell junction
Cell membrane
Membrane
Postsynaptic cell membrane
Synapse
   DomainTransmembrane
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
Phosphoprotein

Gene Ontology (GO)

None. [Check GOA]

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 460460Muscarinic acetylcholine receptor M1

Regions

Topological domain1 – 2424Extracellular Potential
Transmembrane25 – 47231 Potential
Topological domain48 – 6114Cytoplasmic Potential
Transmembrane62 – 82212 Potential
Topological domain83 – 9917Extracellular Potential
Transmembrane100 – 121223 Potential
Topological domain122 – 14120Cytoplasmic Potential
Transmembrane142 – 164234 Potential
Topological domain165 – 18622Extracellular Potential
Transmembrane187 – 209235 Potential
Topological domain210 – 366157Cytoplasmic Potential
Transmembrane367 – 387216 Potential
Topological domain388 – 40114Extracellular Potential
Transmembrane402 – 421207 Potential
Topological domain422 – 46039Cytoplasmic Potential

Amino acid modifications

Modified residue4281Phosphothreonine Potential
Modified residue4511Phosphoserine Potential
Modified residue4551Phosphothreonine Potential
Modified residue4571Phosphoserine Potential
Glycosylation21N-linked (GlcNAc...) Potential
Glycosylation121N-linked (GlcNAc...) Potential
Disulfide bond98 ↔ 178 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q5R949-1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 51095410E07C0FFC

FASTA46051,322
        10         20         30         40         50         60 
MNTSAPPAVS PNITVLAPGK GPWQVAFIGI TTGLLSLATV TGNLLVLISF KVNTELKTVN 

        70         80         90        100        110        120 
NYFLLSLACA DLIIGTFSMN LYTTYLLMGH WALGTLACDL WLALDYVASN ASVMNLLLIS 

       130        140        150        160        170        180 
FDRYFSVTRP LSYRAKRTPR RAALMIGLAW LVSFVLWAPA ILFWQYLVGE RTVLAGQCYI 

       190        200        210        220        230        240 
QFLSQPIITF GTAMAAFYLP VTVMCTLYWR IYRETESRAR ELAALQGSET PGKGGGSSSS 

       250        260        270        280        290        300 
SERSQPGAEG SPGTPPGRCC RCCRAPRLLQ AYSWKEEEEE DEGSMESLTS SEGEEPGSEV 

       310        320        330        340        350        360 
VIKMPMVDPE AQAPTKQPPR SSPNTVKRPT KKGRDRAGKG QKPRGKEQLA KRKTFSLVKE 

       370        380        390        400        410        420 
KKAARTLSAI LLAFILTWTP YNIMVLVSTF CKDCVPETLW ELGYWLCYVN STINPMCYAL 

       430        440        450        460 
CNKAFRDTFR LLLLCRWDKR RWRKIPKRPG SVHRTPSRQC

« Hide

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References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

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Cross-references

Sequence databases

CR859546 mRNA. Translation: CAH91711.1.

3D structure databases

ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Phylogenomic databases

HOVERGENQ5R949.

Family and domain databases

InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
IPR002228. Musac_M1_rcpt.
IPR000995. Musac_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00243. MUSCARINICR.
PR00538. MUSCRINICM1R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProDomQ5R949.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameACM1_PONAB
AccessionPrimary (citable) accession number: Q5R949
Entry history
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: December 21, 2004
Last modified: July 22, 2008
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents