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Reviewed, UniProtKB/Swiss-Prot Q5RF57 (AA1R_PONAB)

Last modified July 22, 2008. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Adenosine receptor A1
Gene names
Name: ADORA1
OrganismPongo abelii (Sumatran orangutan)
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

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Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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Ontologies

Keywords

   Cellular componentCell membrane
Membrane
   DomainTransmembrane
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
Lipoprotein
Palmitate

Gene Ontology (GO)

   Cellular componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 326326Adenosine receptor A1

Regions

Topological domain1 – 1010Extracellular Potential
Transmembrane11 – 33231 Potential
Topological domain34 – 4613Cytoplasmic Potential
Transmembrane47 – 69232 Potential
Topological domain70 – 8011Extracellular Potential
Transmembrane81 – 102223 Potential
Topological domain103 – 12321Cytoplasmic Potential
Transmembrane124 – 146234 Potential
Topological domain147 – 17630Extracellular Potential
Transmembrane177 – 201255 Potential
Topological domain202 – 23534Cytoplasmic Potential
Transmembrane236 – 259246 Potential
Topological domain260 – 2678Extracellular Potential
Transmembrane268 – 292257 Potential
Topological domain293 – 32634Cytoplasmic Potential

Amino acid modifications

Lipidation3091S-palmitoyl cysteine Potential
Glycosylation1481N-linked (GlcNAc...) Potential
Glycosylation1591N-linked (GlcNAc...) Potential
Disulfide bond80 ↔ 169 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q5RF57-1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 5CB621A8CDCCA5FC

FASTA32636,545
        10         20         30         40         50         60 
MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVL LAVADVAVGA 

        70         80         90        100        110        120 
LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLT IAVDRYLRVK IPLRYKMVVT 

       130        140        150        160        170        180 
PRRAAVAIAG CWILSFVVGL TPMFGWNNLS AVERAWAANG SMGEPVIKCE FEKVISMEYM 

       190        200        210        220        230        240 
VYFNFFVWVL PPLLLMVLIY LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL 

       250        260        270        280        290        300 
FLFALSWLPL HILNCITLFC PSCHKPSILT YIAIFLTHGN SAMNPIVYAF RIQKFRVTFL 

       310        320 
KIWNDNFRCQ PAPPIDEDLP EERPDD

« Hide

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References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

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Cross-references

Sequence databases

CR857304 mRNA. Translation: CAH89600.1.

3D structure databases

ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Phylogenomic databases

HOVERGENQ5RF57.

Family and domain databases

InterProIPR001068. Adeno_A1_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
PANTHERPTHR19266:SF15. Adeno_A1_rcpt. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00552. ADENOSINEA1R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProDomQ5RF57.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameAA1R_PONAB
AccessionPrimary (citable) accession number: Q5RF57
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 21, 2004
Last modified: July 22, 2008
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents