Reviewed, UniProtKB/Swiss-Prot Q5TYW2 (A20A1_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin repeat domain-containing protein 20A1

Gene names

Name:	ANKRD20A1
Synonyms:	ANKRD20A

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	823 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 5 ANK repeats.

Ontologies

Keywords
Domain	ANK repeat Coiled coil Repeat
Gene Ontology (GO)
Cellular component	plasma membrane Inferred from direct assay. Source: LIFEdb
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 823	823	Ankyrin repeat domain-containing protein 20A1
Regions
	Repeat	66 – 95	30	ANK 1
	Repeat	99 – 128	30	ANK 2
	Repeat	132 – 161	30	ANK 3
	Repeat	165 – 194	30	ANK 4
	Repeat	198 – 227	30	ANK 5
	Coiled coil	431 – 480	50	Potential
	Coiled coil	565 – 724	160	Potential
	Coiled coil	776 – 805	30	Potential
Experimental info
	Sequence conflict	76	1	T → A in CAB66727. Ref.1
	Sequence conflict	128	1	L → F in CAB66727. Ref.1
	Sequence conflict	499	1	W → R in CAB66727. Ref.1
	Sequence conflict	679	1	R → C in CAB66727. Ref.1
	Sequence conflict	772	1	G → E in CAB66727. Ref.1
	Sequence conflict	805	1	E → G in CAB66727. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q5TYW2-1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 0AE8585829E6E91B	FASTA	823	94,048
	10 20 30 40 50 60 MKLFGFGSRR GQTAQGSIDH VYTGSGYRIR DSELQKIHRA AVKGDAAEVE RCLARRSGDL 70 80 90 100 110 120 DALDKQHRTA LHLACTSGHV QVVTLLVNRK CQIDVCDKEN RTPLIQAVHC QEEACAVILL 130 140 150 160 170 180 EHGANPNLKD IYGNTALHYA VYSESTSLAE KLLSHGAHIE ALDKDNNTPL LFAIICKKEK 190 200 210 220 230 240 MVEFLLKKKA SSHAVDRLRR SALMLAVYYD SPGIVNILLK QNIDVFAQDM CGRDAEDYAI 250 260 270 280 290 300 SHHLTKIQQQ ILEHKKKILK KEKSDVGSSD ESAVSIFHEL RVDSLPASDD KDLNVATKQC 310 320 330 340 350 360 VPEKVSEPLP GSSHEKGNRI VNGQGEGPPA KHPSLKPSTE VEDPAVKGAV QRKNVQTLRA 370 380 390 400 410 420 EQALPVASEE EQERHERSEK KQPQVKEGNN TNKSEKIQLS ENICDSTSSA AAGRLTQQRK 430 440 450 460 470 480 IGKTYPQQFP KKLKEEHDRC TLKQENEEKT NVNMLYKKNR EELERKEKQY KKEVEAKQLE 490 500 510 520 530 540 PTVQSLEMKS KTARNTPNWD FHNHEEMKGL MDENCILKAD IAILRQEICT MKNDNLEKEN 550 560 570 580 590 600 KYLKDIKIVK ETNAALEKYI KLNEEMITET AFRYQQELND LKAENTRLNA ELLKEKESKK 610 620 630 640 650 660 RLEADIESYQ SRLAAAISKH SESVKTERNL KLALERTRDV SVQVEMSSAI SKVKAENEFL 670 680 690 700 710 720 TEQLSETQIK FNALKDKFRK TRDSLRKKSL ALETVQNDLS QTQQQTQEMK EMYQNAEAKV 730 740 750 760 770 780 NNSTGKWNCV EERICHLQRE NAWLVQQLDD VHQKEDHKEI VTNIQRGFIE SGKKDLVLEE 790 800 810 820 KSKKLMNECD HLKESLFQYE REKTEGVVSI KEDKYFQTSR KTI

References

[1]

"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

[2]

"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL136793 mRNA. Translation: CAB66727.1. BX649567 Genomic DNA. Translation: CAH71137.1.
RefSeq	NP_115626.2.
UniGene	Hs.632671
3D structure databases
HSSP	HSSP built from PDB template 1OY3 based on UniProtKB Q60778.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000196774. Homo sapiens. [Contig view]
GeneID	84210.
KEGG	hsa:84210.
Organism-specific databases
HGNC	HGNC:23665. ANKRD20A1.
PharmGKB	PA134953648.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q5TYW2.
HOVERGEN	Q5TYW2.
Gene expression databases
CleanEx	HS_ANKRD20A1.
GermOnline	ENSG00000196774. Homo sapiens.
Family and domain databases
InterPro	IPR002110. ANK. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00023. Ank. 6 hits. [Graphical view]
PRINTS	PR01415. ANKYRIN.
SMART	SM00248. ANK. 6 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 4 hits. [Graphical view]
ProDom	Q5TYW2. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

A20A1_HUMAN

Accession

Primary (citable) accession number: Q5TYW2
Secondary accession number(s): Q9H0H6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	December 7, 2004
Last modified:	July 22, 2008
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)