Reviewed, UniProtKB/Swiss-Prot Q5VUY0 (ADCL3_HUMAN)

Names and origin

Protein names

Recommended name:
    Arylacetamide deacetylase-like 3
    EC=3.1.1.-

Gene names

Name:

AADACL3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	407 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass type II membrane proteinPotential.
Sequence similarities	Belongs to the 'GDXG' lipolytic enzyme family.
Sequence caution	CAH74175.1 sequence differs from that shown. Reason: Erroneous gene model prediction. CAH74176.2 sequence differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal-anchor Transmembrane
Molecular function	Hydrolase
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 407	407	Arylacetamide deacetylase-like 3
Regions
	Topological domain	1 – 3	3	Cytoplasmic Potential
	Transmembrane	4 – 24	21	Signal-anchor for type II membrane protein Potential
	Topological domain	25 – 407	383	Lumenal Potential
Sites
	Active site	119	1	Potential
	Active site	193	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5VUY0-1 [UniParc]. Last modified December 12, 2006. Version 2. Checksum: 9211816751A0BCDF	FASTA	407	46,101
	10 20 30 40 50 60 MWDLALIFLA AACVFSLGVT LWVICSHFFT VHIPAAVGHP VKLRVLHCIF QLLLTWGMIF 70 80 90 100 110 120 EKLRICSMPQ FFCFMQDLPP LKYDPDVVVT DFRFGTIPVK LYQSKASTCT LKPGIVYYHG 130 140 150 160 170 180 GGGVMGSLKT HHGICSRLCK ESDSVVLAVG YRKLPKHKFP VPVRDCLVAT IHFLKSLDAY 190 200 210 220 230 240 GVDPARVVVC GDSFGGAIAA VVCQQLVDRP DLPRIRAQIL IYAILQALDL QTPSFQQRKN 250 260 270 280 290 300 IPLLTWSFIC YCFFQNLDFS SSWQEVIMKG AHLPAEVWEK YRKWLGPENI PERFKERGYQ 310 320 330 340 350 360 LKPHEPMNEA AYLEVSVVLD VMCSPLIAED DIVSQLPETC IVSCEYDALR DNSLLYKKRL 370 380 390 400 EDLGVPVTWH HMEDGFHGVL RTIDMSFLHF PCSMRILSAL VQFVKGL

References

[1]

"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL513016 Genomic DNA. Translation: CAH74175.1. Sequence problems. AL513016 Genomic DNA. Translation: CAH74176.2. Sequence problems.
UniGene	Hs.464705
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000188984. Homo sapiens. [Contig view]
Organism-specific databases
HGNC	HGNC:32037. AADACL3.
GenAtlas	Search...
GeneCards	Search...
GeneLynx	Search...
Phylogenomic databases
HOVERGEN	Q5VUY0.
Gene expression databases
ArrayExpress	Q5VUY0.
CleanEx	HS_AADACL3.
Family and domain databases
InterPro	IPR013094. AB_hydrolase_3. IPR002168. Lipase_GDXG_AS. [Graphical view]
Pfam	PF07859. Abhydrolase_3. 1 hit. [Graphical view]
PROSITE	PS01173. LIPASE_GDXG_HIS. False negative. PS01174. LIPASE_GDXG_SER. False negative. [Graphical view]
ProDom	Q5VUY0. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ADCL3_HUMAN

Accession

Primary (citable) accession number: Q5VUY0
Secondary accession number(s): Q5VUY1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	December 12, 2006
Last modified:	July 22, 2008
This is version 26 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)