Reviewed, UniProtKB/Swiss-Prot Q5VUY2 (ADCL4_HUMAN)

Names and origin

Protein names

Recommended name:
    Arylacetamide deacetylase-like 4
    EC=3.1.1.-

Gene names

Name:

AADACL4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	407 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass type II membrane proteinPotential.
Sequence similarities	Belongs to the 'GDXG' lipolytic enzyme family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal-anchor Transmembrane
Molecular function	Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 407	407	Arylacetamide deacetylase-like 4
Regions
	Topological domain	1 – 4	4	Cytoplasmic Potential
	Transmembrane	5 – 25	21	Signal-anchor for type II membrane protein Potential
	Topological domain	26 – 407	382	Lumenal Potential
Sites
	Active site	119	1	Potential
	Active site	193	1	Potential
Amino acid modifications
	Glycosylation	168	1	N-linked (GlcNAc...) Potential
	Glycosylation	269	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5VUY2-1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: CE95EEE9A2C49970	FASTA	407	46,082
	10 20 30 40 50 60 MAVPWLVLLL ALPIFFLGVF VWAVFEHFLT TDIPATLQHP AKLRFLHCIF LYLVTLGNIF 70 80 90 100 110 120 EKLGICSMPK FIRFLHDSVR IKKDPELVVT DLRFGTIPVR LFQPKAASSR PRRGIIFYHG 130 140 150 160 170 180 GATVFGSLDC YHGLCNYLAR ETESVLLMIG YRKLPDHHSP ALFQDCMNAS IHFLKALETY 190 200 210 220 230 240 GVDPSRVVVC GESVGGAAVA AITQALVGRS DLPRIRAQVL IYPVVQAFCL QLPSFQQNQN 250 260 270 280 290 300 VPLLSRKFMV TSLCNYLAID LSWRDAILNG TCVPPDVWRK YEKWLSPDNI PKKFKNRGYQ 310 320 330 340 350 360 PWSPGPFNEA AYLEAKHMLD VENSPLIADD EVIAQLPEAF LVSCENDILR DDSLLYKKRL 370 380 390 400 EDQGVRVTWY HLYDGFHGSI IFFDKKALSF PCSLKIVNAV VSYIKGI

References

[1]

"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL513016 Genomic DNA. Translation: CAH74173.1.
RefSeq	NP_001013652.1.
UniGene	Hs.209954
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000204518. Homo sapiens. [Contig view]
GeneID	343066.
KEGG	hsa:343066.
Organism-specific databases
HGNC	HGNC:32038. AADACL4.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q5VUY2.
Gene expression databases
CleanEx	HS_AADACL4.
Family and domain databases
InterPro	IPR013094. AB_hydrolase_3. IPR017157. Arylacetamide_deacetylase. IPR002168. Lipase_GDXG_AS. [Graphical view]
Pfam	PF07859. Abhydrolase_3. 1 hit. [Graphical view]
PIRSF	PIRSF037251. Arylacetamide_deacetylase. 1 hit.
PROSITE	PS01173. LIPASE_GDXG_HIS. False negative. PS01174. LIPASE_GDXG_SER. False negative. [Graphical view]
ProDom	Q5VUY2. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ADCL4_HUMAN

Accession

Primary (citable) accession number: Q5VUY2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	December 7, 2004
Last modified:	July 22, 2008
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)