Translation initiation factor 6 - Methanocaldococcus jannaschii

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Reviewed, UniProtKB/Swiss-Prot Q60357 (IF6_METJA)

Last modified July 22, 2008. Version 60. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
Translation initiation factor 6
Short name(s)=aIF-6

Gene names

Name:	eif6
Ordered Locus Names:	MJ0048

Organism

Methanocaldococcus jannaschii (Methanococcus jannaschii) [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	228 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex By similarity.
Sequence similarities	Belongs to the eIF-6 family.
Mass spectrometry	Molecular weight is 24948±6 Da from positions 1 - 228. Determined by MALDI. Ref.2

Ontologies

Keywords
Biological process	Protein biosynthesis
Molecular function	Initiation factor
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	translational initiation Inferred from electronic annotation. Source: HAMAP
Molecular function	translation initiation factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Molecule processing

Chain

228

Translation initiation factor 6

Secondary structure

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228

Helix Strand Turn

Sequences

Sequence

Length

Mass (Da)

Tools

Q60357-1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 94DA7E11C10FCB47
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228

24,459

        10         20         30         40         50         60 
MTMIIRKYFS GIPTIGVLAL TTEEITLLPI FLDKDDVNEV SEVLETKCLQ TNIGGSSLVG 

        70         80         90        100        110        120 
SLSVANKYGL LLPKIVEDEE LDRIKNFLKE NNLDLNVEII KSKNTALGNL ILTNDKGALI 

       130        140        150        160        170        180 
SPELKDFKKD IEDSLNVEVE IGTIAELPTV GSNAVVTNKG CLTHPLVEDD ELEFLKSLFK 

       190        200        210        220 
VEYIGKGTAN KGTTSVGACI IANSKGAVVG GDTTGPELLI IEDALGLI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. Venter J.C. Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
[2]	"Crystal structures of ribosome anti-association factor IF6." Groft C.M., Beckmann R., Sali A., Burley S.K. Nat. Struct. Biol. 7:1156-1164(2000) [PubMed: 11101899] [Abstract] Cited for: FUNCTION, MASS SPECTROMETRY, X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS).

Cross-references

Sequence databases

L77117 Genomic DNA. Translation: AAB98029.1.

PIR

RefSeq

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1G61	X-ray	1.30	A/B	1-228	[»]

ModBase

Genome annotation databases

GeneID

GenomeReviews

Gene locus MJ0048 in contig L77117_GR.

KEGG

NMPDR

fig|243232.1.peg.49.

TIGR

Phylogenomic databases

HOGENOM

Enzyme and pathway databases

BioCyc

MJAN243232:MJ_0048-MON.

Family and domain databases

HAMAP

MF_00032.
[Tree]

InterPro

IPR002769. eIF6.
[Graphical view]

PANTHER

PTHR10784. eIF6. 1 hit.

Pfam

PF01912. eIF-6. 1 hit.
[Graphical view]

PIRSF

PIRSF006413. IF-6. 1 hit.

ProDom

PD006880. eIF6. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00654. eIF6. 1 hit.
[Graphical view]

TIGRFAMs

TIGR00323. eIF-6. 1 hit.

BLOCKS

Other Resources

ProtoNet

Entry information

Entry name

IF6_METJA

Accession

Primary (citable) accession number: Q60357

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	July 22, 2008
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Translation initiation factors

List of translation initiation factor entries

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents