Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot Q60613 (AA2AR_MOUSE)

Last modified July 22, 2008. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Adenosine receptor A2a
Gene names
Name: Adora2a
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Hide | Top

Protein attributes

Sequence length410 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

Hide | Top

General annotation (Comments)

Function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 410410Adenosine receptor A2a

Regions

Topological domain1 – 44Extracellular Potential
Transmembrane5 – 27231 Potential
Topological domain28 – 4013Cytoplasmic Potential
Transmembrane41 – 63232 Potential
Topological domain64 – 7411Extracellular Potential
Transmembrane75 – 97233 Potential
Topological domain98 – 11720Cytoplasmic Potential
Transmembrane118 – 140234 Potential
Topological domain141 – 16828Extracellular Potential
Transmembrane169 – 193255 Potential
Topological domain194 – 22936Cytoplasmic Potential
Transmembrane230 – 253246 Potential
Topological domain254 – 2618Extracellular Potential
Transmembrane262 – 285247 Potential
Topological domain286 – 410125Cytoplasmic Potential

Amino acid modifications

Glycosylation1421N-linked (GlcNAc...) Potential
Glycosylation1491N-linked (GlcNAc...) Potential
Disulfide bond74 ↔ 161 By similarity

Experimental info

Sequence conflict771I → F in AAA19000. Ref.2
Sequence conflict1171K → R in AAA19000. Ref.2
Sequence conflict137 – 1382ML → TA in AAA19000. Ref.2
Sequence conflict1461T → K in AAA19000. Ref.2
Sequence conflict2041K → P in AAA19000. Ref.2

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q60613-1 [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: E5650F1ABD323570

FASTA41044,882
        10         20         30         40         50         60 
MGSSVYIMVE LAIAVLAILG NVLVCWAVWI NSNLQNVTNF FVVSLAAADI AVGVLAIPFA 

        70         80         90        100        110        120 
ITISTGFCAA CHGCLFIACF VLVLTQSSIF SLLAIAIDRY IAIRIPLRYN GLVTGMKAKG 

       130        140        150        160        170        180 
IIAICWVLSF AIGLTPMLGW NNCSQTDENS TKTCGEGRVT CLFEDVVPMN YMVYYNFFAF 

       190        200        210        220        230        240 
VLLPLLLMLA IYLRIFLAAR RQLKQMESQP LPGERTRSTL QKEVHAAKSL AIIVGLFALC 

       250        260        270        280        290        300 
WLPLHIINCF TFFCSTCQHA PPWLMYLAII LSHSNSVVNP FIYAYRIREF RQTFRKIIRT 

       310        320        330        340        350        360 
HVLRRQEPFR AGGSSAWALA AHSTEGEQVS LRLNGHPLGV WANGSAPHSG RRPNGYTLGP 

       370        380        390        400        410 
GGGGSTQGSP GDVELLTQEH QEGQEHPGLG DHLAQGRVGT ASWSSEFAPS

« Hide

Hide | Top

References

[1]"Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor."
Ledent C., Vaugeois J.M., Schiffmann S.N., Pedrazzini T., El-Yacoubi M., Vanderhaeghen J.J., Costentin J., Heath J.K., Vassart G., Parmentier M.
Nature 388:674-678(1997) [PubMed: 9262401] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: 129/Sv.
[2]"Cloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cells."
Marquardt D.L., Walker L.L., Heinemann S.
J. Immunol. 152:4508-4515(1994) [PubMed: 8157966] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-213.
Strain: BALB/c.
Tissue: Bone marrow.

Hide | Top

Cross-references

Sequence databases

Y13344, Y13345 Genomic DNA. Translation: CAA73787.1.
Y13346 mRNA. Translation: CAA73788.1.
U05672 mRNA. Translation: AAA19000.1.
PIRI48932.
UniGeneMm.333734

3D structure databases

HSSPHSSP built from PDB template 1MMH based on UniProtKB P29274.
ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ60613.

Genome annotation databases

EnsemblENSMUSG00000020178. Mus musculus. [Contig view]

Organism-specific databases

MGIMGI:99402. Adora2a.

Phylogenomic databases

HOGENOMQ60613.
HOVERGENQ60613.

Gene expression databases

ArrayExpressQ60613.
CleanExMM_ADORA2A.
GermOnlineENSMUSG00000020178. Mus musculus.

Family and domain databases

InterProIPR001513. Adeno_A2A_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00553. ADENOSINA2AR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProDomQ60613.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

SOURCESearch...
ProtoNetSearch...

Hide | Top

Entry information

Entry nameAA2AR_MOUSE
AccessionPrimary (citable) accession number: Q60613
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: July 22, 2008
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Hide | Top

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents