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Reviewed, UniProtKB/Swiss-Prot Q60614 (AA2BR_MOUSE)

Last modified July 22, 2008. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Adenosine receptor A2b
Gene names
Name: Adora2b
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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Ontologies

Keywords

   Cellular componentCell membrane
Membrane
   DomainTransmembrane
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
Lipoprotein
Palmitate

Gene Ontology (GO)

   Cellular componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 332332Adenosine receptor A2b

Regions

Topological domain1 – 88Extracellular Potential
Transmembrane9 – 31231 Potential
Topological domain32 – 4413Cytoplasmic Potential
Transmembrane45 – 67232 Potential
Topological domain68 – 7811Extracellular Potential
Transmembrane79 – 101233 Potential
Topological domain102 – 12120Cytoplasmic Potential
Transmembrane122 – 144234 Potential
Topological domain145 – 17834Extracellular Potential
Transmembrane179 – 203255 Potential
Topological domain204 – 23532Cytoplasmic Potential
Transmembrane236 – 259246 Potential
Topological domain260 – 2678Extracellular Potential
Transmembrane268 – 291247 Potential
Topological domain292 – 33241Cytoplasmic Potential

Amino acid modifications

Lipidation3111S-palmitoyl cysteine Potential
Glycosylation1531N-linked (GlcNAc...) Potential
Glycosylation1631N-linked (GlcNAc...) Potential
Disulfide bond78 ↔ 171 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q60614-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: C8A3108371AD1C1C

FASTA33236,065
        10         20         30         40         50         60 
MQLETQDALY VALELVIAAL AVAGNVLVCA AVGASSALQT PTNYFLVSLA TADVAVGLFA 

        70         80         90        100        110        120 
IPFAITISLG FCTDFHGCLF LACFVLVLTQ SSIFSLLAVA VDRYLAIRVP LRYKGLVTGT 

       130        140        150        160        170        180 
RARGIIAVLW VLAFGIGLTP FLGWNSKDSA TSNCTELGDG IANKSCCPLT CLFENVVPMS 

       190        200        210        220        230        240 
YMVYFNFFGC VLPPLLIMLV IYIKIFMVAC KQLQSMELMD HSRTTLQREI HAAKSLAMIV 

       250        260        270        280        290        300 
GIFALCWLPV HAINCITLFH PALAKDKPKW VMNVAILLSH ANSVVNPIVY AYRNRDFRYS 

       310        320        330 
FHKIISRYVL CQAETKGGSG QAGAQSTLSL GL

« Hide

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References

[1]"Cloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cells."
Marquardt D.L., Walker L.L., Heinemann S.
J. Immunol. 152:4508-4515(1994) [PubMed: 8157966] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Bone marrow.

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Cross-references

Sequence databases

U05673 mRNA. Translation: AAA19001.1.
PIRI48933.
UniGeneMm.40740

3D structure databases

HSSPHSSP built from PDB template 1MMH based on UniProtKB P29274.
ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ60614.

Genome annotation databases

EnsemblENSMUSG00000018500. Mus musculus. [Contig view]

Organism-specific databases

MGIMGI:99403. Adora2b.

Phylogenomic databases

HOGENOMQ60614.
HOVERGENQ60614.

Gene expression databases

ArrayExpressQ60614.
CleanExMM_ADORA2B.
GermOnlineENSMUSG00000018500. Mus musculus.

Family and domain databases

InterProIPR001435. Adeno_A2B_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00554. ADENOSINA2BR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProDomQ60614.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

SOURCESearch...
ProtoNetSearch...

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Entry information

Entry nameAA2BR_MOUSE
AccessionPrimary (citable) accession number: Q60614
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 22, 2008
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents