Reviewed, UniProtKB/Swiss-Prot Q6JQN1 (ACD10_HUMAN)

Names and origin

Protein names

Recommended name:
    Acyl-CoA dehydrogenase family member 10
      Short name=ACAD-10

Gene names

Name:

ACAD10

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1059 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Tissue specificity	Widely expressed with higher expression in liver, kidney, pancreas and spleen.
Sequence similarities	Belongs to the acyl-CoA dehydrogenase family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6JQN1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6JQN1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     883-890: GHGEVRFE → CFLPSFSL
     891-1059: Missing.

Isoform 3 (identifier: Q6JQN1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-398: Missing.
     399-413: HSVDLQAVGLEDYGK → MLEYLSLTFLISVKI
     883-890: GHGEVRFE → CFLPSFSL
     891-1059: Missing.

Notes: No experimental confirmation available.

Isoform 4 (identifier: Q6JQN1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     285-285: P → L
     286-1059: Missing.

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 1059	1059	Acyl-CoA dehydrogenase family member 10
Natural variations
	Alternative sequence	1 – 398	398	Missing in isoform 3.
	Alternative sequence	285	1	P → L in isoform 4.
	Alternative sequence	286 – 1059	774	Missing in isoform 4.
	Alternative sequence	399 – 413	15	HSVDL…EDYGK → MLEYLSLTFLISVKI in isoform 3.
	Alternative sequence	883 – 890	8	GHGEVRFE → CFLPSFSL in isoform 2 and isoform 3.
	Alternative sequence	891 – 1059	169	Missing in isoform 2 and isoform 3.
	Natural variant	200	1	Q → R: dbSNP rs35276160.
	Natural variant	216	1	T → P: dbSNP rs35753710.
	Natural variant	463	1	D → N: dbSNP rs36046440.
	Natural variant	880	1	A → V: dbSNP rs34245489.
Experimental info
	Sequence conflict	124	1	S → P in BAC03869. Ref.2
	Sequence conflict	197	1	C → M in BAC05046. Ref.2
	Sequence conflict	663	1	V → D in BAC03869. Ref.2
	Sequence conflict	688	1	H → R in BAC03869. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: B8D4376FCF73D746	FASTA	1,059	118,834
	10 20 30 40 50 60 MCVRSCFQSP RLQWVWRTAF LKHTQRRHQG SHRWTHLGGS TYRAVIFDMG GVLIPSPGRV 70 80 90 100 110 120 AAEWEVQNRI PSGTILKALM EGGENGPWMR FMRAEITAEG FLREFGRLCS EMLKTSVPVD 130 140 150 160 170 180 SFFSLLTSER VAKQFPVMTE AITQIRAKGL QTAVLSNNFY LPNQKSFLPL DRKQFDVIVE 190 200 210 220 230 240 SCMEGICKPD PRIYKLCLEQ LGLQPSESIF LDDLGTNLKE AARLGIHTIK VNDPETAVKE 250 260 270 280 290 300 LEALLGFTLR VGVPNTRPVK KTMEIPKDSL QKYLKDLLGI QTTGPLELLQ FDHGQSNPTY 310 320 330 340 350 360 YIRLANRDLV LRKKPPGTLL PSAHAIEREF RIMKALANAG VPVPNVLDLC EDSSVIGTPF 370 380 390 400 410 420 YVMEYCPGLI YKDPSLPGLE PSHRRAIYTA MNTVLCKIHS VDLQAVGLED YGKQGDYIPR 430 440 450 460 470 480 QVRTWVKQYR ASETSTIPAM ERLIEWLPLH LPRQQRTTVV HGDFRLDNLV FHPEEPEVLA 490 500 510 520 530 540 VLDWELSTLG DPLADVAYSC LAHYLPSSFP VLRGINDCDL TQLGIPAAEE YFRMYCLQMG 550 560 570 580 590 600 LPPTENWNFY MAFSFFRVAA ILQGVYKRSL TGQASSTYAE QTGKLTEFVS NLAWDFAVKE 610 620 630 640 650 660 GFRVFKEMPF TNPLTRSYHT WARPQSQWCP TGSRSYSSVP EASPAHTSRG GLVISPESLS 670 680 690 700 710 720 PPVRELYHRL KHFMEQRVYP AEPELQSHQA SAARWSPSPL IEDLKEKAKA EGLWNLFLPL 730 740 750 760 770 780 EADPEKKYGA GLTNVEYAHL CELMGTSLYA PEVCNCSAPD TGNMELLVRY GTEAQKARWL 790 800 810 820 830 840 IPLLEGKARS CFAMTEPQVA SSDATNIEAS IREEDSFYVI NGHKWWITGI LDPRCQLCVF 850 860 870 880 890 900 MGKTDPHAPR HRQQSVLLVP MDTPGIKIIR PLTVYGLEDA PGGHGEVRFE HVRVPKENMV 910 920 930 940 950 960 LGPGRGFEIA QGRLGPGRIH HCMRLIGFSE RALALMKARV KSRLAFGKPL VEQGTVLADI 970 980 990 1000 1010 1020 AQSRVEIEQA RLLVLRAAHL MDLAGNKAAA LDIAMIKMVA PSMASRVIDR AIQAFGAAGL 1030 1040 1050 SSDYPLAQFF TWARALRFAD GPDEVHRATV AKLELKHRI
	Isoform 2 [UniParc]. Checksum: A244BA80925C1BB4		890	100,352
	10 20 30 40 50 60 MCVRSCFQSP RLQWVWRTAF LKHTQRRHQG SHRWTHLGGS TYRAVIFDMG GVLIPSPGRV 70 80 90 100 110 120 AAEWEVQNRI PSGTILKALM EGGENGPWMR FMRAEITAEG FLREFGRLCS EMLKTSVPVD 130 140 150 160 170 180 SFFSLLTSER VAKQFPVMTE AITQIRAKGL QTAVLSNNFY LPNQKSFLPL DRKQFDVIVE 190 200 210 220 230 240 SCMEGICKPD PRIYKLCLEQ LGLQPSESIF LDDLGTNLKE AARLGIHTIK VNDPETAVKE 250 260 270 280 290 300 LEALLGFTLR VGVPNTRPVK KTMEIPKDSL QKYLKDLLGI QTTGPLELLQ FDHGQSNPTY 310 320 330 340 350 360 YIRLANRDLV LRKKPPGTLL PSAHAIEREF RIMKALANAG VPVPNVLDLC EDSSVIGTPF 370 380 390 400 410 420 YVMEYCPGLI YKDPSLPGLE PSHRRAIYTA MNTVLCKIHS VDLQAVGLED YGKQGDYIPR 430 440 450 460 470 480 QVRTWVKQYR ASETSTIPAM ERLIEWLPLH LPRQQRTTVV HGDFRLDNLV FHPEEPEVLA 490 500 510 520 530 540 VLDWELSTLG DPLADVAYSC LAHYLPSSFP VLRGINDCDL TQLGIPAAEE YFRMYCLQMG 550 560 570 580 590 600 LPPTENWNFY MAFSFFRVAA ILQGVYKRSL TGQASSTYAE QTGKLTEFVS NLAWDFAVKE 610 620 630 640 650 660 GFRVFKEMPF TNPLTRSYHT WARPQSQWCP TGSRSYSSVP EASPAHTSRG GLVISPESLS 670 680 690 700 710 720 PPVRELYHRL KHFMEQRVYP AEPELQSHQA SAARWSPSPL IEDLKEKAKA EGLWNLFLPL 730 740 750 760 770 780 EADPEKKYGA GLTNVEYAHL CELMGTSLYA PEVCNCSAPD TGNMELLVRY GTEAQKARWL 790 800 810 820 830 840 IPLLEGKARS CFAMTEPQVA SSDATNIEAS IREEDSFYVI NGHKWWITGI LDPRCQLCVF 850 860 870 880 890 MGKTDPHAPR HRQQSVLLVP MDTPGIKIIR PLTVYGLEDA PGCFLPSFSL
	Isoform 3 [UniParc]. Checksum: 7D43DC0750659E9F		492	55,693
	10 20 30 40 50 60 MLEYLSLTFL ISVKIQGDYI PRQVRTWVKQ YRASETSTIP AMERLIEWLP LHLPRQQRTT 70 80 90 100 110 120 VVHGDFRLDN LVFHPEEPEV LAVLDWELST LGDPLADVAY SCLAHYLPSS FPVLRGINDC 130 140 150 160 170 180 DLTQLGIPAA EEYFRMYCLQ MGLPPTENWN FYMAFSFFRV AAILQGVYKR SLTGQASSTY 190 200 210 220 230 240 AEQTGKLTEF VSNLAWDFAV KEGFRVFKEM PFTNPLTRSY HTWARPQSQW CPTGSRSYSS 250 260 270 280 290 300 VPEASPAHTS RGGLVISPES LSPPVRELYH RLKHFMEQRV YPAEPELQSH QASAARWSPS 310 320 330 340 350 360 PLIEDLKEKA KAEGLWNLFL PLEADPEKKY GAGLTNVEYA HLCELMGTSL YAPEVCNCSA 370 380 390 400 410 420 PDTGNMELLV RYGTEAQKAR WLIPLLEGKA RSCFAMTEPQ VASSDATNIE ASIREEDSFY 430 440 450 460 470 480 VINGHKWWIT GILDPRCQLC VFMGKTDPHA PRHRQQSVLL VPMDTPGIKI IRPLTVYGLE 490 DAPGCFLPSF SL
	Isoform 4 [UniParc]. Checksum: 8852125314974C50		285	32,196
	10 20 30 40 50 60 MCVRSCFQSP RLQWVWRTAF LKHTQRRHQG SHRWTHLGGS TYRAVIFDMG GVLIPSPGRV 70 80 90 100 110 120 AAEWEVQNRI PSGTILKALM EGGENGPWMR FMRAEITAEG FLREFGRLCS EMLKTSVPVD 130 140 150 160 170 180 SFFSLLTSER VAKQFPVMTE AITQIRAKGL QTAVLSNNFY LPNQKSFLPL DRKQFDVIVE 190 200 210 220 230 240 SCMEGICKPD PRIYKLCLEQ LGLQPSESIF LDDLGTNLKE AARLGIHTIK VNDPETAVKE 250 260 270 280 LEALLGFTLR VGVPNTRPVK KTMEIPKDSL QKYLKDLLGI QTTGL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a human cDNA ACAD10 mapped to chromosome 12q24.1." Ye X., Ji C., Zhou C., Zeng L., Gu S., Ying K., Xie Y., Mao Y. Mol. Biol. Rep. 31:191-195(2004) [PubMed: 15560374] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Fetal brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Brain and Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4). Tissue: Skin.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY323912 mRNA. Translation: AAQ88260.1. AK092356 mRNA. Translation: BAC03869.1. AK097425 mRNA. Translation: BAC05046.1. BC015056 mRNA. Translation: AAH15056.1. Different initiation. BC126358 mRNA. Translation: AAI26359.1.
RefSeq	NP_079523.3.
UniGene	Hs.331141
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000111271. Homo sapiens. [Contig view]
GeneID	80724.
KEGG	hsa:80724.
Organism-specific databases
H-InvDB	HIX0011001.
HGNC	HGNC:21597. ACAD10.
MIM	611181. gene.
PharmGKB	PA134976754.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q6JQN1.
Gene expression databases
ArrayExpress	Q6JQN1.
CleanEx	HS_ACAD10.
Family and domain databases
InterPro	IPR006091. Acyl-CoA_DHase/Oxase_M. IPR006089. Acyl-CoA_DHase_CS. IPR006090. Acyl-CoA_Oxase/DHase_1. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. IPR002575. APH_trans. IPR005834. Dehalogen-like_hydro. IPR006402. HAD-SF_hydro_IA_v3. IPR011945. HAD-SF_ppase_IA/epoxid_hydro_N. IPR005833. Haloacid_DHase/epoxide_hydro. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 1 hit.
Pfam	PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. PF01636. APH. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00413. HADHALOGNASE.
TIGRFAMs	TIGR02247. HAD-1A3-hyp. 1 hit. TIGR01509. HAD-SF-IA-v3. 1 hit.
PROSITE	PS00072. ACYL_COA_DH_1. False negative. PS00073. ACYL_COA_DH_2. False negative. [Graphical view]
ProDom	Q6JQN1. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

ACD10_HUMAN

Accession

Primary (citable) accession number: Q6JQN1
Secondary accession number(s): Q8N828, Q8NAP2, Q96BX5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	July 5, 2004
Last modified:	July 22, 2008
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)