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Reviewed, UniProtKB/Swiss-Prot Q6NUJ1 (SAPL1_HUMAN)

Last modified July 22, 2008. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Proactivator polypeptide-like 1
Cleaved into the following 5 chains:
    1- Recommended name:
            Saposin A-like
    2- Recommended name:
            Saposin B-Val-like
    3- Recommended name:
            Saposin B-like
    4- Recommended name:
            Saposin C-like
    5- Recommended name:
            Saposin D-like
Gene names
Name: PSAPL1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length521 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

May activate the lysosomal degradation of sphingolipids By similarity.

Subcellular location

SecretedPotential.

Sequence similarities

Contains 2 saposin A-type domains.

Contains 4 saposin B-type domains.

Sequence caution

The sequence BAC05143.1 differs from that shown. Reason: Erroneous termination at position 510. Translated as Trp.

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Ontologies

Keywords

   Biological processLipid metabolism
Sphingolipid metabolism
   Cellular componentSecreted
   DomainRepeat
Signal
   PTMGlycoprotein

Gene Ontology (GO)

None. [Check GOA]

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Signal peptide1 – 1717 Potential
Propeptide18 – 5942 By similarity
Chain61 – 14484Saposin A-like By similarity
Propeptide146 – 18035 By similarity
Chain181 – 25777Saposin B-Val-like By similarity
Chain181 – 25676Saposin B-like By similarity
Propeptide259 – 28830 By similarity
Chain290 – 36980Saposin C-like By similarity
Propeptide370 – 39122 By similarity
Chain392 – 47382Saposin D-like By similarity
Propeptide474 – 52148 By similarity

Regions

Domain19 – 5941Saposin A-type 1
Domain60 – 14485Saposin B-type 1
Domain180 – 25879Saposin B-type 2
Domain290 – 37081Saposin B-type 3
Domain392 – 47382Saposin B-type 4
Domain475 – 51541Saposin A-type 2

Amino acid modifications

Glycosylation2011N-linked (GlcNAc...) Potential
Glycosylation3111N-linked (GlcNAc...) By similarity
Disulfide bond64 ↔ 140 By similarity
Disulfide bond67 ↔ 134 By similarity
Disulfide bond95 ↔ 107 By similarity
Disulfide bond184 ↔ 254 By similarity
Disulfide bond187 ↔ 248 By similarity
Disulfide bond213 ↔ 224 By similarity
Disulfide bond294 ↔ 366 By similarity
Disulfide bond297 ↔ 360 By similarity
Disulfide bond325 ↔ 336 By similarity
Disulfide bond396 ↔ 469 By similarity
Disulfide bond399 ↔ 463 By similarity
Disulfide bond427 ↔ 438 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q6NUJ1-1 [UniParc].

Last modified March 20, 2007. Version 2.
Checksum: 0E1ED7B942D1ECB2

FASTA52156,627
        10         20         30         40         50         60 
MLCALLLLPS LLGATRASPT SGPQECAKGS TVWCQDLQTA ARCGAVGYCQ GAVWNKPTAK 

        70         80         90        100        110        120 
SLPCDVCQDI AAAAGNGLNP DATESDILAL VMKTCEWLPS QESSAGCKWM VDAHSSAILS 

       130        140        150        160        170        180 
MLRGAPDSAP AQVCTALSLC EPLQRHLATL RPLSKEDTFE AVAPFMANGP LTFHPRQAPE 

       190        200        210        220        230        240 
GALCQDCVRQ VSRLQEAVRS NLTLADLNIQ EQCESLGPGL AVLCKNYLFQ FFVPADQALR 

       250        260        270        280        290        300 
LLPPQELCRK GGFCEELGAP ARLTQVVAMD GVPSLELGLP RKQSEMQMKA GVTCEVCMNV 

       310        320        330        340        350        360 
VQKLDHWLMS NSSELMITHA LERVCSVMPA SITKECIILV DTYSPSLVQL VAKITPEKVC 

       370        380        390        400        410        420 
KFIRLCGNRR RARAVHDAYA IVPSPEWDAE NQGSFCNGCK RLLTVSSHNL ESKSTKRDIL 

       430        440        450        460        470        480 
VAFKGGCSIL PLPYMIQCKH FVTQYEPVLI ESLKDMMDPV AVCKKVGACH GPRTPLLGTD 

       490        500        510        520 
QCALGPSFWC RSQEAAKLCN AVQHCQKHVW KEMHLHAGEH A

« Hide

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References

« Hide 'large scale' references
[1]"Large scale analysis of gene expression in the course of epidermal differentiation."
Toulza E., Guerrin M.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Epidermis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 209-521.
Tissue: Testis.

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Cross-references

Sequence databases

DQ991252 mRNA. Translation: ABJ55983.1.
BC068579 mRNA. Translation: AAH68579.1. Different initiation.
AK097698 mRNA. Translation: BAC05143.1. Sequence problems.
RefSeqNP_001078851.1.
UniGeneHs.662523

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSG00000178597. Homo sapiens. [Contig view]
GeneID768239.
KEGGhsa:768239.

Organism-specific databases

HGNCHGNC:33131. PSAPL1.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOVERGENQ6NUJ1.

Gene expression databases

ArrayExpressQ6NUJ1.
CleanExHS_PSAPL1.

Family and domain databases

InterProIPR003119. SapA.
IPR007856. SapB_1.
IPR008138. SapB_2.
IPR008373. Saposin.
IPR011001. Saposin_like.
IPR008139. SaposinB.
[Graphical view]
Gene3DG3DSA:1.10.225.10. Saposin_like. 4 hits.
PfamPF02199. SapA. 2 hits.
PF05184. SapB_1. 3 hits.
PF03489. SapB_2. 3 hits.
[Graphical view]
PRINTSPR01797. SAPOSIN.
SMARTSM00162. SAPA. 2 hits.
SM00741. SapB. 4 hits.
[Graphical view]
PROSITEPS51110. SAP_A. 2 hits.
PS50015. SAP_B. 4 hits.
[Graphical view]
ProDomQ6NUJ1.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameSAPL1_HUMAN
AccessionPrimary (citable) accession number: Q6NUJ1
Secondary accession number(s): A0A184, Q8N7T4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: July 22, 2008
This is version 37 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents